Microglial cells are brain-specific macrophages that swiftly react to disruptive events in the brain. Microglial activation leads to specific modifications, including proliferation, morphological changes, migration to the site of insult, and changes in gene expression profiles. A change in inflammatory status has been linked to many neurodegenerative diseases such as Parkinson's disease and Alzhei

We establish an operator theoretic version of the Wiener–Ikehara Taube-rian theorem and use it to obtain a short proof of the Prime number theorem that should be accessible to anyone with a basic knowledge of operator theory and Fourier analysis.

Premise: Besides the beneficial plant-fungus symbiosis in mycorrhizal plants, bacteria also enhance plant fitness via tripartite interactions. While bacterial associations are presumably just as important for the obligate mycorrhizal family Orchidaceae, little is known about orchid associating bacteria (OAB). Methods: We examined the OAB communities of two, congeneric, terrestrial orchids, Platant

We consider a perturbation problem for embedded eigenvalues of a self-adjoint differential operator in L2(R;Rn). In particular, we study the set of all small perturbations in an appropriate Banach space for which the embedded eigenvalue remains embedded in the continuous spectrum. We show that this set of small perturbations forms a smooth manifold and we specify its co-dimension. Our methods invo

Uppfattningarna om hur samhället ska utformas varierar kraftigt mellan olika tidsepoker. Under efterkrigstiden fick idén om att socialtjänsten skulle vara en aktiv aktör i utvecklingen av välfärdsstaten starkt fotfäste bland politiska partier och bland professionella. Det skulle ske genom medverkan i samhällsplaneringen och genom att arbeta strukturinriktat. Men ideal är en sak och verklighet en a

Due to the high variance in response rates concerning anti-PD1 immunotherapy (IT), there is an unmet need to discover innovative biomarkers to predict immune checkpoint inhibitor (ICI)-efficacy. Our study included 62 Caucasian advanced-stage non-small cell lung cancer (NSCLC) patients treated with anti-PD1 ICI. Gut bacterial signatures were evaluated by metagenomic sequencing and correlated with p

Utvärdering behövs för att skapa kunskap om vilka interventioner som fungerar på lite längre sikt, för vilka de fungerar och vad som gör att de fungerar. I kapitlet presenteras en så kallad utvärderingscykel som jag illustrerar med ett preventionsprogram som förbättrat barns tandhälsa. Kapitlet tar även upp implementering av resultat från utvärdering och avimplementering av det som kan behöva fasa

This work is primarily a legal commentary on the final appeal judgment of the Supreme People’s Court of China on the Archangelos Gabriel case. In the opinion of the author, the judgment is sound and reasonable and brings to light a measure of judicial activism into the arena of salvage litigation in China. Basically, the apex Court held that the case did not fall within the purview of salvage in t

The original chapter on adaptive-filter models addressed the issue of how far such models were consistent with experimental evidence. Here we consider one particularly important kind of evidence, that concerning the nature of the synaptic plasticity that underlies cerebellar learning. The basic decorrelation learning rule employed by the adaptive-filter model can be translated into spike timing-de

Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incor

Deep learning (DL) models for radiation therapy (RT) image segmentation require accurately annotated training data. Multiple organ delineation guidelines exist; however, information on the used guideline is not provided with the delineation. Extraction of training data with coherent guidelines can therefore be challenging. We present a supervised classification method for pelvis structure delineat

The positive outcomes of engaging in the arts are increasingly reported in the research literature, supporting the use of the arts to enhance individual and community health and wellbeing. However, little attention is given to the less positive aspects of arts engagement. In some countries, healthcare practitioners and link workers can refer service-users experiencing mental health issues to socia

This longitudinal study examined the relationship between flexibility-activity and blood-pressure (BP) change among older adults in Japan. Our study included 452 older adults who took part in our survey in both 2012/2013 and 2017/2018. The seated systolic blood pressure (SBP) and diastolic BP (DBP) were measured both at baseline and at the 5 years follow-up. The frequencies of the different physic

Kan træer have en form for bevidsthed? Kan de handle på eget initiativ?Thomas Arentzen er ekspert indenfor tidlig kristen poesi og litteratur og har forsket i de tidlige kristnes opfattelse af træer. Sidste efterår var Arentzen i Istanbul. Her mødte han træer, som har stået på hellige steder i hundredvis af år.

Short supraventricular tachycardias (S-SVTs) have been associated with a higher risk of developing atrial fibrillation (AF). Hence, identification of participants with such arrhythmias may increase the yield of AF screening. However, the lower signal quality of ECGs recorded using handheld screening devices challenges the detection of S-SVT. In the present work, a new method for detection of S-SVT

Atrial fibrillation (AF) is the most common heart arrhythmia, characterized by the presence of fibrillatory waves (f-waves) in the ECG. We introduce a voting scheme to estimate the dominant atrial frequency (DAF) of f-waves. Methods: We analysed a subset of Holter recordings obtained from the University of Virginia AF Database. 100 Holter recordings with manually annotated AF events, resulting in

Background: Differences in the performance of estimated glomerular filtration rate (eGFR) equations have been attributed to the mathematical form of the equations and to differences between patient demographics and measurement methods. We evaluated differences in serum creatinine (SCr) and eGFR in cohorts matched for age, sex, body mass index (BMI) and measured GFR (mGFR). Methods: White North Ame