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Chemotherapy-induced neuropathic pain (CINP) remains a major unmet medical need. Estrogen receptor beta (ERβ)-selective agonists represent a novel strategy for treating CINP because they are neuroprotective and may also have anticancer activity. We confirmed that ERβ-selective agonists have antiallodynic effects in the spinal nerve ligation model of neuropathic pain. We then showed that structural

One of the factors limiting the performance of organic solar cells (OSCs) is their large energy losses (E loss) in the conversion from photons to electrons, typically believed to be around 0.6 eV and often higher than those of inorganic solar cells. In this work, a novel low band gap polymer PIDTT-TID with a optical gap of 1.49 eV is synthesized and used as the donor combined with PC71BM in solar

A typical obstacle to cancer therapy is the limited distribution of low molecular weight anticancer drugs within the carcinoma tissue. In experimental carcinoma, imatinib (STI571) increases efficacy of synchronized chemotherapy, reduces tumor interstitial fluid pressure, and increases interstitial fluid volume. STI571 also increases the water-perfusable fraction in metastases from human colorectal

The enzymatic interesterification of a solvent-free, equimolar mixture of trilaurin and 1,3-palmitin-2-olein was studied using three immobilized lipase preparations as catalysts. Analysis of triacylglycerol (TAG) content and fatty acid (FA) distribution monitored the lipase-catalyzed interesterification in sn-1,3 positions and FA exchange in the sn-2 position caused by acyl migration. Lipase from

Juveniles of numerous lizard species have a vividly blue-coloured tail that likely serves to deflect predator attacks toward the autotomizable tail rather than the lizard's body. The shades of blue colour in the tails of juvenile Plestiodon latiscutatus lizards vary across populations, most notably among those island populations with different predator assemblages. Here, we determine if this intra

In facultative partial migrants some individuals in a population are migratory and others are resident and individuals decide each year anew which strategy to choose. While the proportion of birds migrating is in part determined by environmental conditions and competitive abilities, the timing of individual departure and behaviours on route are little understood. Individuals encounter different en

Despite the discovery of antibiotics almost a century ago, infectious diseases continue to be a substantial cause of human mortality and morbidity worldwide, especially in developing countries. The adverse affects of infectious diseases are thought to increase over the coming years as the widespread misuse of antibiotic leads to the emergence of strains for which current therapies are ineffective.

The record of scolecodonts (polychaete jaws) from the Ordovician of Sweden is very poor. In this paper, we document a Darriwilian (Middle Ordovician) assemblage recovered from palynological samples from the “orthoceratite limestone” (Lanna and Holen limestones) of Mount Kinnekulle, Västergötland, southern Sweden. The collection of diminutive specimens forms an assemblage taxonomically composed mai

Artikeln är en sammanfattning av delprojektet Betongreparation inom det större projektet Bygginnovationen som är ett nationellt flerårigt forsknings-och utvecklingsprogram finansierat av Vinnova och svensk byggindustri. I artikeln görs en beskrivning av olika betongskador. Åldersfördelningen hos svenska konstruktioner beskrivs. Principer för val av reparationsmetod och reparationsmaterial diskuter

...fortsättning av artikel från Bygg och teknik 6/97 om rökgasspridning via ventilationssystem. I artikeln diskuteras olika beräkningsmodeller för rökspridning i ventilationssystem.

Vid byggnadsmaterial, Lunds tekniska högskola, har problem med sprickbildning i puts på isolering studerats under ett antal år. Projektet startade i större skala 1999 med generella brottmekaniska analyser, laboratoriemätningar av brukets egenskaper och "fullskaleförsök" på provväggar i laboratorium. Resultaten från de första årens studier redovisades översiktligt i Bygg & teknik 8/02. Bland an

Sprickbildning i puts på isolering har inträffat i ökande omfattning på senare tid. 1997 togs problemställningen upp vid Byggnadsmaterial, Lunds Tekniska Högskola. Genom brottmekansika beräkningar, renodlade laboratorieförsök samt studier på provväggar och analys av skadefall i praktiken har olika inverkande faktorer klarlagts. I denna artikel sammanfattas hittills framkomna resultat och hypoteser

Purpose To explore the association of baseline trabecular bone structure with incident tibiofemoral (TF) osteoarthritis (OA) and with increase in joint space narrowing (JSN) score. Methods The Multicenter Osteoarthritis Study (MOST) includes subjects with or at risk for knee OA. Knee radiographs were scored for Kellgren–Lawrence (KL) grade and JSN at baseline, 30, 60 and 84 months. Knees (KL ≤ 1)