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Overexpression of the receptor tyrosine kinase MET has been linked to poor survival in several cancer types, and MET has been suggested to interact with stem cell networks. In vitro studies have further suggested a possible benefit of a combined treatment using PARP and MET inhibitors. We used a tissue microarray (TMA) with 130 samples of advanced-stage high-grade serous fallopian tube/ovarian can
Presentation av bakgrunden till, utgångspunkt för och materialet till en kurs om samverkan för lärare, forskare och verksamhetsstöd.
The article looks into the multicultural settings of Liviu Rebreanu’s novel “Amândoi” (Both) by briefly examining the representation of its main, minor or incidental characters, either intelligentsia or common people. Ethnicity, social and professional statuses are considered as elements of multiculturalism. The continuous increase of suspense, the open ending, the parody in the undertone, and the
Internet-of-Things (IoT) systems consist of spatially distributed interacting devices. In contrast to desktop applications, IoT systems are always running and need to deal with unresponsive devices and weak connectivity. In this thesis, we propose techniques for simplifying the development of such systems. The work addresses IoT systems organised as reusable services connected by compositions. We
This paper examines the Swedish record of competition in the supply of bank notes in the 19th century. Between 1831 and 1902, private commercial banks, organized as partnerships with unlimited liability for their owners, issued notes competing with the notes of the Riksbank, the bank owned by the Riksdag, the Swedish parliament. The private banks turned out to be competitive in this market despite
We study the origins of support for gender-related affirmative action (AA) in two pre-registered online experiments (N = 1, 700). Participants act as employers who decide whether to use AA in hiring job candidates. We implement three treatments to disentangle the preference for AA stemming from i) perceived gender differences in productivity, ii) beliefs about AA effects on productivity, or iii) ot
A recent study proposed by Westerlund (CCE in Panels with General Unknown Factors, Econometrics Journal, 21, 264-276, 2018) showed that a very popular Common Correlated Effects (CCE) estimator is significantly more applicable than it was thought before. Contrary to the usual stationarity assumption, common factors can in fact be much more general and not unit root only. This also helps to alleviat
Gender intersects as a major fault-line in increasingly polarized, contemporary global politics. Many democratic states in the global North and South have adopted pro-gender norms in their foreign policies, while other states and populist regimes have resisted the promotion of gender equality and women's rights. This article analyses how political leaders harness gender dynamics to further their p
S1P (Sphingosine-1-phosphate) is an important regulator of immune cell trafficking and vascular dysfunction contributing to the development and progression of overt hypertension. Although targeting S1P signaling revealed therapeutic potential in different experimental hypertension studies, validations of S1P-blood pressure (BP) associations in humans are lacking. In a translational approach, we ex
BACKGROUND: Due to demographic changes, hospital emergency departments in many countries are overcrowded. Internationally, several primary healthcare models have been introduced as alternatives to hospitalisation. In Norway, municipal acute wards (MAWs) have been implemented as primary care wards that provide observation and medical treatment for 24 h. The intention is to replace hospitalisation f
Islands are among the last regions on Earth settled and transformed by human activities, and they provide replicated model systems for analysis of how people affect ecological functions. By analyzing 27 representative fossil pollen sequences encompassing the past 5000 years from islands globally, we quantified the rates of vegetation compositional change before and after human arrival. After human
Extreme ultraviolet (XUV) light is notoriously difficult to control due to its strong interaction cross section with media. We demonstrate a method to overcome this problem by using opto-optical modulation guided by a geometrical model to shape XUV light. A bell-shaped infrared light pulse is shown to imprint a trace of its intensity profile onto the XUV light in the far-field, such that a change
This chapter discusses the question of whether increasing the level of standardization in a disaster risk management system will increase its effectiveness. Based on the results from several studies conducted in the context of the Swedish disaster risk management system, the authors argue that there are both positive and negative effects of increased standardization. More precisely, studies based
This review represents a detailed and comprehensive discussion of the Thermal Field Theory (TFT) concepts and key results in Yukawa-type theories. We start with a general pedagogical introduction into the TFT in the imaginary- and real-time formulation. As phenomenologically relevant implications, we present a compendium of thermal decay rates for several typical reactions calculated within the fr
Neurological disorders are listed as the second leading cause of death worldwide. Stroke and Alzheimer’s disease (AD) are the major contributors to neurological disorders of deaths. Every year, around 14 million new people are affected by stoke and nearly 10 million new cases of AD are diagonosed worldwide. The number of deaths and disabilities due to these disorders have increased considerably. N
While ecosystem service (ES) assessments become a more and more important source of knowledge, there is a need for synthesis approaches that make the results usable to support decisions. Effective synthesis approaches can reduce the information burden produced by multiple ES assessments and help decision-makers to compare alternative options and to assess their impacts. In this review, we focus on
Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts or routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants are eligible for the trial and to facilitate recruitment, to deliver an embedded intervention, to collect trial outcome data, or a combination of these purposes. This repor
Randomised controlled trials conducted using cohorts and routinely collected data, including registries, electronic health records and administrative databases, are increasingly used in healthcare intervention research. A Consolidated Standards of Reporting Trials (CONSORT) statement extension for trials conducted using cohorts and routinely collected data (CONSORT-ROUTINE) has been developed with
