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Sperm DNA integrity in cancer patients : the effect of disease and treatment

As oncological treatment might impair the patients' fertility, male cancer patients are offered to cryopreserve semen prior to treatment. Impaired sperm DNA quality is associated with reduced fertility, and in case of assisted reproduction, sperm DNA integrity may have an impact on choice of method. Therefore, we have assessed sperm DNA integrity in cancer patients, comparing pre- and post-treatme

Nitric oxide-producing cells project from retinal grafts to the inner plexiform layer of the host retina

PURPOSE: Amacrine cells expressing nitric oxide synthase (NOS) are seen in normal retinas and retinal grafts to extend long processes, which can be followed for long distances. Taking advantage of the morphologic features of these cells, the present study examined whether graft-host connections involve cells capable of producing nitric oxide, a recognized retinal neuromodulatory compound.METHODS:

Maternal morbidity and mortality in in-vitro fertilization.

Pregnancies following in-vitro fertilization (IVF) are known to be at increased risk of a number of pregnancy- and delivery-related complications when compared with non-IVF pregnancies. Most of these complications seem to be due to underlying fertility problems. Ovarian stimulation carries a marked risk for two serious conditions - ovarian torsion and ovarian hyperstimulation syndrome - both of wh

Desmopressin in vitro effects on platelet function, monitored with Multiplate, ROTEM and Sonoclot.

Background and aims The vasopressin analogue desmopressin has demonstrated efficacy in decreasing bleeding time by increasing the circulating levels of coagulation factor VIII and von Willebrand factor, but also by direct effects on platelets. Previous studies have demonstrated contrasting results regarding the effect of desmopressin on platelets in vitro. The aim of this study was to investigate

Structural basis and functional effects of the interaction between complement inhibitor C4b-binding protein and DNA.

Human C4b-binding protein (C4BP) is a soluble, multiple-subunit inhibitor of complement that circulates in blood. Recently C4BP was shown to bind DNA, reduce DNA release from necrotic cells and limit DNA-mediated complement activation in solution. Herein we employed nuclear magnetic resonance spectroscopy to measure chemical shift perturbations and used them to restrain the computational docking o

Konkurrensrätt i förändring: modernisering, decentralisering och rättssäkerhet

EG-kommissionen har sedan 1997 arbetat med att revidera den europeiska konkurrensrätten och anpassa den till ny ekonomisk teori. Moderniseringen har lett till att regelverket förtydligats genom det vertikala gruppundantaget (1999), de horisontella gruppundantagen (2001) och bildistributionsundantaget (2002). En revision av 1996 års teknikförordning ligger i tiden. Även procedurreglerna genomgår ge

A product-process dependency definition method

The success of most software companies depends largely on software product quality. High product quality is usually a result of advanced software development processes. Hence, improvement actions should be selected based on sound knowledge about the dependencies between software product quality attributes and software development processes. This article describes a method for developing product/pr

Aligning Corporate Strategy, Procurement Strategy and E-Procurement Tools

This paper presents a framework for assessing alignment between corporate strategy, procurement strategy and purchasing tools. The framework is built on generation of rents as its common denominator for assessing alignment between the levels. Three types of rents are identified, monopoly rents (utilising market power, squeezing out cost), Ricardian rents (realising value from scarce intrafirm reso