A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tum

The current view of type 1 diabetes (T1D) is that it is an immune-mediated disease where lymphocytes infiltrate the pancreatic islets, promote killing of beta cells and cause overt diabetes. Although tissue resident immune cells have been demonstrated in several organs, the composition of lymphocytes in human healthy pancreatic islets have been scarcely studied. Here we aimed to investigate the ph

A note on the relation between psychiatric ill-health and terrorism.

With the continuous development, in the last decades, of analytical techniques providing complex information at single cell level, the study of cell heterogeneity has been the focus of several research projects within analytical biotechnology. Nonetheless, the complex interplay between environmental changes and cellular responses is yet not fully understood, and the integration of this new knowled

We present an on-chip acoustofluidic platform for harvesting a target microalgal species from a heterogeneous population of cells and particles based on their size, density, and compressibility in a rapid, non-invasive, energy-efficient, continuously running, and automated manner. For our proof-of-principle demonstration, we use Euglena gracilis as a target species. Specifically, we show the simul

A photographic play in five acts based on Poe's The Raven and Lou Reed's lyric. Raven is the Trickster, the one who became and remained everything to every man - god, animal, human being, buffoon, he was before good and evil, denier, affirmer, destroyer and creator.

The seasonality of solar irradiance and precipitation may regulate seasonal variations in tropical forests carbon cycling. Controversy remains over their importance as drivers of seasonal dynamics of net primary productivity in tropical forests. We use ground data from nine lowland Amazonian forest plots collected over 3 years to quantify the monthly primary productivity (NPP) of leaves, reproduct

Around the globe more than 350,000 citizens live with a sophisticated hearing aid device called Cochlear Implant. In many countries CI is an institutionalized medical procedure for restoring deafened with a technological sense of hearing but the social challenges for users is a largely unexplored issue. Addressing this social dimension, the article explores how Cochlear Implant works as a boundary

A theoretical framework for understanding public library development is presented; plural agonistics is used in combination with an approach inspired by post-humanism. The framework is related to examples from a study of two Swedish public libraries. Antagonism is viewed as foundational, and democracy as an ongoing process, the task being to transform antagonism to agonism, with institutions like

Grundämnena molybden, wolfram och vanadin spelar viktiga roller i biologiska system. De återfinns bl a i ett antal enzymer, där de genomför s k syreöverföringsreaktioner, d v s de tar en syreatom från en molekyl och överför den till en annan molekyl. Sådana reaktioner är av stor vikt i kemi, eftersom införandet av syre i olika molekyler är viktig vid framställning av många kemikalier som kan använA series of new dioxomolybdenum(VI) and -tungsten(VI) complexes of tripodal tetradentate and tridentate amino bis- and monophenolate ligands have been synthesized and characterized. The majority of the complexes are mononuclear, but dimeric and trimeric oxo-bridged M(VI) (M = Mo, W) were also obtained. The reactivities of all complexes have been investigated in oxygen atom transfer (OAT) processes

This study documents the advancement of laying dates in three species of tits (Paridae) in southernmost Sweden during recent decades, and the absence of a similar response in the pied flycatcher Ficedula hypoleuca. It is based on several different nestbox studies; the oldest one starting in 1969. During 1969 to 2012, mean spring temperatures in the study area increased by between 0.06 and 0.08 °C This study documents the advancement of laying dates in three species of tits (Paridae) in southernmost Sweden during recent decades, and the absence of a similar response in the pied flycatcher Ficedula hypoleuca. It is based on several different nestbox studies; the oldest one starting in 1969. During 1969 to 2012, mean spring temperatures in the study area increased by between 0.06 and 0.08°C p

Former studies that have attempted to characterize individual socio-demographic factors associated with long-term benzodiazepine use were based on relatively small sample sizes and/or self-reported data. Our aim was to clarify this using large-scale primary health care data from Sweden. The present study covered 71 primary health care centres containing individual-level data from a total of 919, 9

The emergence of drug-resistant pathogens has triggered the search for more efficient antimicrobial agents and formulations for treatment of infections. In recent years, combination therapy has become one of the effective clinical practices in treating infections. The present study deals with the effect of haloduracin, a lantibiotic bateriocin and chloramphenicol against clinically important bacte

In most studies on technology change, the analysis of cost reductions of new energy technologies has been narrow and has often neglected essential processes related to the deployment of new technologies, such as photovoltaics (PV). However, in the case of distributed PV systems, other costs than for the PV modules – aka the deployment or balance-of-system costs – are significant. This review study

The aim of this study is to find potential utilization practice of rice straw in India from an environmental perspective. Life cycle assessment (LCA) is conducted for four most realistic utilization practices of straw including: (1) incorporation into the field as fertilizer (2) animal fodder (3) electricity (4) biogas. The results show that processing of 1 ton straw to electricity and biogas resu

Advanced 1-D models for Secondary Settling Tanks (SSTs) explicitly account for several phenomena that influence the settling process (such as hindered settling and compression settling). For each of these phenomena a valid mathematical expression needs to be selected and its parameters calibrated to obtain a model that can be used for operation and control. This is, however, a challenging task as

The safe application of nanotechnology devices in biomedicine requires fundamental understanding on how they interact with and affect the different components of biological systems. In this respect, the cellular membrane, the cell envelope, certainly represents an important target or barrier for nanosystems. Here we report on the interaction between functionalized SuperParamagnetic Iron Oxide Nano

Diffusion MRI (dMRI) provides rich information on the white matter of the human brain, enabling insight into neurological disease, normal aging, and neuroplasticity. We present BundleMAP, an approach to extracting features from dMRI data that can be used for supervised classification, regression, and hypothesis testing. Our features are based on aggregating measurements along nerve fiber bundles,

The Ediacaran Doushantuo Formation (DST) is renowned for exceptionally preserved Precambrian fossils including metazoans. Some of these fossils, particularly microfossils such as multicellular algae and acanthomorphic acritarchs, are preserved in DST chert nodules. To better understand the geomicrobiological processes that contributed to the authigenic formation of DST chert nodules and facilitate