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The association of copeptin with metabolic risk markers is modified by region of origin

Iraqi born immigrants in Sweden have higher prevalence of metabolic diseases compared to native Swedes. Copeptin, a marker for vasopressin, is associated with increased risk of metabolic disease. In this cross-sectional population study based on the MEDIM cohort we investigated differences in copeptin levels between Iraqi and Swedish born individuals and if the association between copeptin and car

Health and work-related factors as predictors of still being active in working life at age 66 and 72 in a Swedish population : A longitudinal study

BACKGROUND: Health and work environment are known factors in being active in working life beyond legal retirement. OBJECTIVE: To investigate sociodemographic, health and work environment factors as possible predictors of being active in working life at ages 66 and 72. Secondly, investigate eventual changes over time, shortly after a major reform in the Swedish pension system, and predictors of sti

Calibration procedures and data correction of ePix100 detectors at the European XFEL

The European XFEL is a research facility that delivers extremely bright and short coherent X-ray pulses of tunable energy at MHz repetition rate, providing unprecedented capabilities to conduct scientific research across multiple domains. Among the suite of deployed detectors, several ePix100 modules, belonging to the family of ePix detectors developed at SLAC, are used. These charge-integrating h

Understanding the Role of Activation Loop Mutants in Drug Efficacy for FLT3-ITD

The type III receptor tyrosine kinase FLT3 is a pivotal kinase for hematopoietic progenitor cell regulation, with significant implications in acute myeloid leukemia (AML) through mutations like internal tandem duplication (ITD). This study delves into the structural intricacies of FLT3, the roles of activation loop mutants, and their interaction with tyrosine kinase inhibitors. Coupled with this,

Navigating the Legal Uncertainty and Informality in Authoritarian Regimes: Legal Culture, Governance and Business Environment in Uzbekistan

Academic debates on law and society relations in authoritarian regimes continue to revolve around issues of the dysfunctional legal system, corruption and informality, clientelistic legal culture, and how the authoritarian regimes in this region deploy law as a means for suppressing dissent. However, in this article, we argue that the legal landscape of authoritarian regimes should not be viewed f

Surgical management of necrotising enterocolitis in Sweden : A national cohort study

Aim: Necrotising enterocolitis (NEC) is the dominating surgical emergency in preterm neonates. The aims were to investigate indications, surgical management and mortality for surgically treated neonates with NEC. Methods: Data were retrieved from the Swedish Neonatal Quality Register for Swedish neonates with surgically treated NEC from 1 January 2017 to 31 December 2021. Diagnosis was validated b

The natal dispersal behaviour of first year Yellow-billed Kites Milvus aegyptius in Nigeria

Den gulnäbbade gladan – Människans granne Afrika är en kontinent känt för sina stora och karakteristiska gräsätare som har bevisat sig falla offer för oss människor med minskande populationer som följd. Forskning från Nigeria tyder på att till skillnad från gräsätarna så verkar en av Afrikas vanligaste rovfågel dra nytta av att leva nära oss människor. I alla fall under delar av året. Drastiska Natal dispersal influences a population’s growth rate and its adaptability to new environments. Yellow-billed Kite (YBK) is an intra-African avian migrant and the most wide-spread and abundant raptor species in Africa. Still, very little is known about this species’ natal dispersal behaviour. This study aims to investigate dispersal distance, the number of Temporary Settlement Areas (TSA) and whic

Invariant natural killer T cells and incidence of first-time coronary events : a nested case-control study

Aims Invariant natural killer T (iNKT) cells, a T cell subset that is CD1d-restricted and expresses a semi-invariant T cell receptor, have been proposed to contribute to dyslipidaemia-driven cardiovascular disease due to their ability to specifically recognize lipid antigens. Studies in mice have attributed pro-atherogenic properties to iNKT cells, but studies in humans investigating associations

Anti-Incretin Gut Features Induced by Feed Supplementation with Alpha-Amylase : Studies on EPI Pigs

The acini-islet-acinar (AIA) axis concept justifies the anatomical placement of the Langerhans islets within the exocrine pancreatic parenchyma and explains the existence of the pancreas as a single organ. Amylase has been suggested to play a key role as an anti-incretin factor. Oral glucose tolerance tests (OGTT) were performed on 18 piglets in both a healthy (prior to pancreatic duct ligation (P

Developing and testing the feasibility of a new internet-based intervention : A case study of people with stroke and occupational therapists

IntroductionInternet-based interventions are called for within rehabilitation to meet the limited access to support for self-management after stroke. Therefore, a new intervention program, “Strategies for Empowering activities in Everyday life” (SEE) was developed. The aim of this study was to explore and describe how clients with stroke and their occupational therapists experienced the SEE intervIntroductionInternet-based interventions are called for within rehabilitation to meet the limited access to support for self-management after stroke. Therefore, a new intervention program, “Strategies for Empowering activities in Everyday life” (SEE) was developed. The aim of this study was to explore and describe how clients with stroke and their occupational therapists experienced the SEE interv

Simulations of7Be and10Be with the GEOS-Chem global model v14.0.2 using state-of-The-Art production rates

The cosmogenic radionuclides 7Be and 10Be are useful tracers for atmospheric transport studies. Combining 7Be and 10Be measurements with an atmospheric transport model can not only improve our understanding of the radionuclide transport and deposition processes but also provide an evaluation of the transport process in the model. To simulate these aerosol tracers, it is critical to evaluate the in

Fungal Wars Effects of Nutrient Environment on Soil Fungal Interactions

This study investigates the underlying mechanisms of the ‘Gadgil effect’, a phenomenon where competition between ectomycorrhizal (EM) and saprotrophic fungi suppresses the growth of saprotrophic fungi. The findings showed that nutritional conditions and fungal habitats significantly influence fungal interactions and their outcomes. Under conditions of both nitrogen-rich and scarce environments, EM

Germline mutation rate is elevated in young and old parents in Caenorhabditis remanei

The effect of parental age on germline mutation rate across generations is not fully understood. While some studies report a positive linear relationship of mutation rate with increasing age, others suggest that mutation rate varies with age but not in a linear fashion. We investigated the effect of parental age on germline mutations by generating replicated mutation accumulation lines in Caenorha

Role of hospital and patient factors in the outcome of reoperations for primary hyperparathyroidism : a retrospective multicenter cohort study

BACKGROUND: There are few data on outcomes after reintervention for persistent or recurrent primary hyperparathyroidism (PHPT). The authors hypothesized that the variation in outcomes at the hospital level after reoperation would be significant. After accounting for this variability, some patient-level clinical criteria could be identified to help inform treatment decisions in this patient populat

Navigating narratives: A framing analysis of AUKUS in Chinese state media

This thesis investigates how the framing of AUKUS, a trilateral security and defense collaboration consisting of Australia, United Kingdom, and the United States, is portrayed by Chinese state media. AUKUS, established on September 15, 2021, is mainly focusing on providing Australia with nuclear-powered submarine technology. This turn of event has attracted a lot of attention and enquiry from Chin

Association of beta-blockers beyond 1 year after myocardial infarction and cardiovascular outcomes

Objective Beta-blockers (BB) are an established treatment following myocardial infarction (MI). However, there is uncertainty as to whether BB beyond the first year of MI have a role in patients without heart failure or left ventricular systolic dysfunction (LVSD). Methods A nationwide cohort study was conducted including 43 618 patients with MI between 2005 and 2016 in the Swedish register for co

Football training as a non-pharmacological treatment of the global aging population—A topical review

In the present topical mini-review, the beneficial impact of small-sided game football training for the increasing elderly global population is presented. As a multicomponent type of physical activity, football training executed on small pitched with 4–6 players in each team is targeting a myriad of physiological systems and causes positive adaptations of relevance for several non-communicable dis