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Heme oxygenase is an enzyme that degrades heme, thereby recycling iron in most organisms, including humans. Pervious density functional theory (DFT) calculations have suggested that iron(III) hydroxyheme, an intermediate generated in the first step of heme degradation by heme oxygenase, is converted to iron(III) superoxo oxophlorin in the presence of dioxygen. In this article, we have studied the
Dynamic Charging, meaning supplying electric energy to electric vehicles while moving and also referred to as Electric Road Systems (ERS), can be implemented in a number of different ways. In Sweden, no less than four different technologies are being developed and/or demonstrated. This is, in an international comparison, unique. This paper represents an effort to describe these different technolog
Electric Road Systems (ERS) are analysed here as a feasible solution for the electrification of heavy traffic, where the predominant approach for passenger cars based only on batteries and a network of fast-charging stations combined with slower overnight charging becomes unrealistic due to the large amount of batteries required. Nonetheless, this study shows that in most cases, building such ERS
Objectives: Maggots of the blowfly Lucilia sericata are used for the treatment of chronic wounds. Previously we reported that maggot excretions/secretions (ES) break down Staphylococcus aureus biofilms but do not kill the bacteria. As many antibiotics are not effective against biofilms we assessed the effect of combinations of ES and antibiotics on S. aureus biofilms and on the survival of the bac
Lactoferrin plays an important role in the defense against infections, including herpes simplex virus (HSV) keratitis. We studied the impact of three single nucleotide polymorphisms in the human lactoferrin gene on the susceptibility to HSV infections of the eye and the severity of such infections. Lactoferrin gene polymorphisms were determined by PCR combined with restriction fragment length anal
Chemokines comprise a class of structurally related proteins that are involved in many aspects of leukocyte migration under basal and inflammatory conditions. In addition to the large number of genes, limited processing of these proteins by a variety of enzymes enhances the complexity of the total spectrum of chemokine variants. We have recently shown that the native chemokine CXCL10 is processed
Psoriasis vulgaris, a type-1 cytokine-mediated chronic skin disease, can be treated successfully with fumaric acid esters (FAE). Beneficial effects of this medication coincided with decreased production of IFN-γ. Since dendritic cells (DC) regulate the differentiation of T helper (Th) cells, this study focussed on effects of monomethylfumarate (MMF, bioactive metabolite of FAE) on polarization of
This study explores the relationship between dietary patterns and social structure in a pre-industrial mining community in Salberget, Sweden c. 1470 to 1600 A.D. using a combination of different research approaches and tools, including archaeology, osteology, bone chemistry and history.The correlation between demographic criteria (sex and age) and archaeological variables (burial type and burial l
Transition narratives are stories promoting particular pathways for development, promoting specific actions, strategies, and interventions to enable certain outcomes in socio-technical transitions. Narratives centered around biorefineries take a significant role in the growing bioeconomy discourse, yet they express remarkably different visions for the transition. The paper uses Q methodology to id
Contrary to the traditional understanding of place branding inspired by product, service and corporation branding, the present paper adopts place branding interdisciplinary literature in order to develop a conceptual framework that focuses on the constituting features of place brands as a form of public brands. The paper suggests the way place brands are constituted is via a co-branded complex and
Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction for cell migration. Here, we test whether the integrin, when engaged to an extracellular ligand and the cytoskeleton, adopts a specific orientation dictated by the direction of actin flow on the surface of migrating cells. We insert GFP into the rigid, ligand-binding head of the integrin, model with
Enterprise Resource Planning (ERP) system literature reports little research on the specificities of an industry analysis. Based on a theoretical model we assess ERP Value between Manufacturing and Services industries in Small and Medium Enterprises (SMEs) across the Iberian region (Portugal and Spain). The empirical test was conducted through structural equation modeling, using data from 261 firm
The MEthane Remote sensing Lidar missioN (MERLIN) aims at demonstrating the spaceborne active measurement of atmospheric methane, a potent greenhouse gas, based on an Integrated Path Differential Absorption (IPDA) nadir-viewing LIght Detecting and Ranging (Lidar) instrument. MERLIN is a joint French and German space mission, with a launch currently scheduled for the timeframe 2021/22. The German S
Many automated gating algorithms for flow cytometry data are based on the concept of unimodal cell populations. However, in this article, we show that criteria previously used to make decisions on unimodality cannot adequately distinguish unimodal from bimodal densities. We show that dip and bandwidth tests for unimodality, taken from the statistics literature, can do this with consistent and low
The Gebel el Silsila Project is a multi-disciplinary Swedish mission dedicated to the study of the archaeological remains at Ancient Egypt’s largest sandstone quarry of Gebel el Silsila, Mountain of Chain, just north of Kom Ombo in the Aswan region. This paper presents a general summary of the epigraphical and archaeo-topographical survey of the largest quarry on the east bank – Quarry 34 or the MThe Gebel el Silsila Project is a multi-disciplinary Swedish mission dedicated to the study of the archaeological remains at Ancient Egypt’s largest sandstone quarry of Gebel el Silsila, Mountain of Chain, just north of Kom Ombo in the Aswan region. This paper presents a general summary of the epigraphical and archaeo-topographical survey of the largest quarry on the east bank – Quarry 34 or the M
