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The HEM Proteins : A novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis

We report the identification of a new family of proteins, termed the HEM family, which show distinct expression patterns in blood cells and the central nervous system. Through the isolation and characterization of the corresponding brain-specificDrosophila(dhem-2) and rat orthologues (Hem-2), and through the detection of theCaenorhabditis elegansHem-2 orthologue in the database, we show that this

tenm, a Drosophila gene related to tenascin, is a new pair-rule gene

We describe the molecular characterization of the Drosophila gene tenm, a large transcription unit spanning > 110 kb of DNA. tenm encodes a large extracellular protein of 2515 amino acids related to the extracellular matrix molecule tenascin. The Tenm protein is found in seven stripes during the blastoderm stage, and each stripe overlaps with the even-skipped stripes. tenm mutants show a phenotype

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase

The gene encoding the Drosophila protein phosphatase 2A 55 kd regulatory subunit (PR55) is located at 85F and directs the synthesis of differentially spliced transcripts. Maternal RNAs are present at very high levels in early embryos and decline around cellularization. Zygotic transcripts are present mainly in the developing embryonic nervous system and gonads. Transcripts are uniformly distribute

Tena, a Drosophila gene related to tenascin, shows selective transcript localization

We report the identification and molecular characterization of tena*, a Drosophila gene located at 11A6-9 on the X-chromosome. The deduced protein of 782 amino acids contains eight tenascin-type EGF-like repeats not described in Drosophila before, but lacks the fibronectin type III repeats and the fibrinogen homology present in the vertebrate tenascin molecules. Tena codes for a large transcript w

Elevated plasma copeptin levels identify the presence and severity of non-alcoholic fatty liver disease in obesity

Introduction: Copeptin is the stable surrogate marker of vasopressin (VP), which is released in response to elevated plasma osmolality or low blood pressure. Elevated plasma copeptin levels are associated with higher risk of insulin resistance-related disorders, such as type 2 diabetes (T2DM), metabolic syndrome (MS), and cardiovascular disease, and experimental reduction of circulating VP levels

Essays on Urban Economics

AbstractBlind, I. 2015. Essays on Urban Economics. Economic studies 153. xii+199 pp. Uppsala:Department of Economics. ISBN 978-91-85519-60-6.This thesis consists of four self-contained essays.Essay 1 (with Olof Åslund and Matz Dahlberg): In this essay we investigate the impact ofcommuter train access on individual labor market outcomes. Our study considers the exogenousintroduction of a commuter t

Molecular cloning and developmental expression of the catalytic and 65-kDa regulatory subunits of protein phosphatase 2A in Drosophila

cDNA clones encoding the catalytic subunit and the 65-kDa regulatory subunit of protein phosphatase 2A (PR65) from Drosophila melanogaster have been isolated by homology screening with the corresponding human cDNAs. The Drosophila clones were used to analyze the spatial and temporal expression of the transcripts encoding these two proteins. The Drosophila PR65 cDNA clones contained an open reading

Network of interactions among pair-rule genes regulating paired expression during primordial segmentation of Drosophila

A model of the trans-regulation of the Drosophila pair-rule segmentation gene, paired (prd), has been derived from the observed alterations in the distribution of prd transcripts during early embryogenesis in single and double pair-rule mutants. Important aspects of the model include the following features and implications: (i) The regulation of prd is subject to a regulatory hierarchy among pair-

Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro

Two new paired domain genes of Drosophila, Pox meso and Pox neuro, are described. In contrast to the previously isolated paired domain gnees, paired and gooseberry, which contain both a paired and a homeodomain (PHox genes), Pox meso and Pox neuro possess no homeodomain. Evidence suggesting that the new genes encode tissue-specific transcriptional factors and belong to the same regulatory cascade

On particle multiplicities distribution in three-jet events

A thorough verification of the distinct differences in the properties of quark and gluon jets is considered as one of the most instructive tests of the basic ideas of QCD. In the real life experiments such a comparison appears to be quite a delicate task and various subtle issues require further theoretical efforts. In this paper we discuss in detail the possibility to extract the theoretically ad

Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.

The gooseberry (gsb) locus contains two closely linked genes, BSH9 and BSH4, which are structurally related to each other and to the paired (prd) gene. Sequence analysis of genomic DNA and cDNA shows that BSH9 and BSH4 can encode proteins of 427 and 452 amino acids, respectively. The structural homology between these two putative proteins and the prd protein consists essentially of two domains for

Generating Non-Projective Word Order in Statistical Linearization

We propose a technique to generate non-projective word orders in an efficient statistical linearization system. Our approach predicts liftings of edges in an unordered syntactic tree by means of a classifier, and uses a projective algorithm for tree linearization. We obtain statistically significant improvements on six typologically different languages: English, German, Dutch, Danish, Hungarian, a

Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

Extending our search for homologous domains of the Drosophila paired gene, two closely linked genes at the gooseberry locus have been isolated. Both genes are expressed with a single segment periodicity but with different spatial and temporal expression patterns. While the transcripts of one gene appear earlier and are equally distributed between ectoderm and mesoderm, those of the second gene acc

Structure of the segmentation gene paired and the Drosophila PRD gene set as part of a gene network

The sequence of paired, a pair-rule gene required for segmentation in Drosophila, is presented. A search for genes with domains homologous to the paired gene was initiated and three homologues from a set of 12 were characterized with respect to temporal or spatial expression and sequence homologies. All four are transcribed in early development, one in the oocyte and during cleavage stages in the

Isolation of the paired gene of Drosophila and its spatial expression during early embryogenesis

We have cloned the paired gene of Drosophila melanogaster, a pair-rule gene required for the establishment of proper segmentation. The transcriptional pattern in young embryos shows developmental polarities along the antero-posterior and dorso-ventral axes. Transcripts, initially expressed with a double-segment periodicity, switch to a single-segment repeat during syncytial blastoderm.