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Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-codi
Channel Shortening in Wireless Communication
The concept of Channel Shortening (CS) is a well-known technique that has a rich history over 40 years. CS transfers linear vector channels such as multi-input multi-output (MIMO) and intersymbol interference (ISI) channels into ``shortened'' versions, for the purpose of reducing demodulation-complexity and improving data-transmission performance. The original CS idea can trace back to the minimum
Optically stimulated luminescence (OSL) dosimetry in irradiated alumina substrates from mobile phone resistors
In this study the dosimetric properties of alumina (Al2O3) substrates found in resistors retrieved from mobile phones were investigated. Measurements of the decline of optically stimulated luminescence (OSL) generated following exposure of these substrates to ionising radiation showed that 16% of the signal could still be detected after 2 years (735 days). Further, the magnitude of the regenerativ
Bacterioplankton responses to increased organic carbon and nutrient loading in a boreal estuary—separate and interactive effects on growth and respiration
Increases in the terrestrial export of dissolved organic carbon (C) to rivers may be associated with additional loading of organic nitrogen (N) and phosphorus (P) to the coastal zone. However, little is known about how these resources interact in the regulation of heterotrophic bacterioplankton metabolism in boreal coastal ecosystems. Here, we measured changes in bacterioplankton production (BP) a
How does tillage intensity affect soil organic carbon? A systematic review
Background: The loss of carbon (C) from agricultural soils has been, in part, attributed to tillage, a common practice providing a number of benefits to farmers. The promotion of less intensive tillage practices and no tillage (NT) (the absence of mechanical soil disturbance) aims to mitigate negative impacts on soil quality and to preserve soil organic carbon (SOC). Several reviews and meta-analy
A novel weighted likelihood estimation with empirical Bayes flavor
We propose a novel approach to estimation, where a set of estimators of a parameter is combined into a weighted average to produce the final estimator. The weights are chosen to be proportional to the likelihood evaluated at the estimators. We investigate the method for a set of estimators obtained by using the maximum likelihood principle applied to each individual observation. The method can be
Modeling of Salt Sorption in Volcanic Ash Soil
Groundwater pollution by nitrate from agricultural fields is a worldwide problem. To improve the understanding of nitrate transport processes through volcanic ash soils overlying groundwater aquifers, salt sorption experiments were performed. Salt sorption is the process that involves the simultaneous use of cation and anion adsorption mechanisms without changing the pH. Prepared six different con
Expression of staphylococcal enterotoxins under stress encountered during food production and preservation
Staphylococcal food poisoning (SFP) is the most prevalent cause of food-borne intoxications worldwide. Consumption of enterotoxins preformed in food causes violent vomiting and can be fatal in children and the elderly. While being repressed by competing bacteria in most matrices, Staphylococcus aureus benefits from crucial competitive advantages in foods with high osmolarity or low pH. During rece
Interplay between isoscalar and isovector correlations in neutron-rich nuclei
The interplay between isoscalar and isovector correlations in the 1- states in neutron-rich (N≠Z) even-even nuclei is studied, taking as examples of the nuclei, O14822 and O16824. The excitation modes explored are isovector dipole and isoscalar compression dipole modes. The self-consistent Hartree-Fock plus the random-phase approximation with the Skyrme interaction, SLy4, is solved in coordinate s
J /ψ Elliptic Flow in Pb-Pb Collisions at sNN =5.02 TeV
We report a precise measurement of the J/ψ elliptic flow in Pb-Pb collisions at sNN=5.02 TeV with the ALICE detector at the LHC. The J/ψ mesons are reconstructed at midrapidity (|y|
Association between sensory function and hop performance and self-reported outcomes in patients with anterior cruciate ligament injury.
BACKGROUND:In patients with anterior cruciate ligament (ACL) deficiency (ACLD) or reconstruction (ACLR), sensory deficits are commonly assessed as knee kinesthesia using time-consuming laboratory equipment. Portable equipment such as that used for evaluation of vibration sense would be preferable. In contrast to kinesthesia, vibration sense is not well studied in these patients.OBJECTIVES:1) To st
Editorial: On scientific amnesia
Developing a virtual reference service based on team development and collaborative learning
Sharpening The Infodesk Toolbox: Peer Learning Through Flexible Modules To Ensure Sustainability In Professional Development
Basing arguments on evidence: the unexpected outcome of a cultural probe
Rates of glycaemic deterioration in a real-world population with type 2 diabetes
Aims/hypothesis: There is considerable variability in how diabetes progresses after diagnosis. Progression modelling has largely focused on ‘time to failure’ methods, yet determining a ‘coefficient of failure’ has many advantages. We derived a rate of glycaemic deterioration in type 2 diabetes, using a large real-world cohort, and aimed to investigate the clinical, biochemical, pharmacological and
Predominance of girls with cancer in families with multiple childhood cancer cases
Background: Recent studies indicate that one of four childhood cancers can be attributed to hereditary genetic abnormalities. Methods: The Lund Childhood Cancer Genetic study includes newly diagnosed childhood cancer patients as well as childhood cancer survivors visiting the Department of Pediatrics or the Late Effect Clinic at Skåne University Hospital, Lund, Sweden. Questionnaires regarding fam
Apolipoprotein M Protects Against Lipopolysaccharide-Induced Acute Lung Injury via Sphingosine-1-Phosphate Signaling
Abstract: It had been demonstrated that apolipoprotein M (apoM) is an important carrier of sphingosine-1-phosphate (S1P) in blood, and the S1P has critical roles in the pathogenesis of sepsis-induced acute lung injury (ALI). In the present study, we investigated whether apoM has beneficial effects in a mouse model after lipopolysaccharide (LPS)-induced ALI. Forty-eight mice were divided into two g
Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment
While the importance of iron for tumor development is widely appreciated, the exact sources of tumor-supporting iron largely remain elusive. The possibility that iron might be provided by stromal cells in the tumor microenvironment was not taken into account so far. In the present study, we show that tumor-associated macrophages (TAM) acquire an iron-release phenotype upon their interaction with t