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Hypoxia Generated by Avian Embryo Growth Induces the HIF-α Response and Critical Vascularization

Cancer research has transformed our view on cellular mechanisms for oxygen sensing. It has been documented that these mechanisms are important for maintaining animal tissues and life in environments where oxygen (O2) concentrations fluctuate. In adult animals, oxygen sensing is governed by the Hypoxia Inducible Factors (HIFs) that are stabilized at low oxygen concentrations (hypoxia). However, the

Pseudorapidity distributions of charged particles as a function of mid- and forward rapidity multiplicities in pp collisions at √s = 5.02, 7 and 13 TeV

The multiplicity dependence of the pseudorapidity density of charged particles in proton–proton (pp) collisions at centre-of-mass energies s=5.02, 7 and 13 TeV measured by ALICE is reported. The analysis relies on track segments measured in the midrapidity range (| η| < 1.5). Results are presented for inelastic events having at least one charged particle produced in the pseudorapidity interval

Cultural connotations of categorizing the environment : does the presence of a linguistic gender and noun class system in any way connect to cultural feature data?

Social studies indicate that a gendered language may limit equal opportunities for women (Jakiela and Ozier 2018). Likewise, the use of gender-neutral pronouns may improve gender equality (Tavits and Pérez 2019). We aim to investigate this issue using cross-cultural data. The studies of (Whyte 1978) and (Sanderson and Donoghue 1989) (W1978/SD1989) connect gender inequality to cultural features.Tes

Estimation of pre-dolomitisation porosity and permeability of a nummulitic carbonate reservoir rock using the Multi-Component Architecture Method (MCAM)

The fossiliferous Eocene carbonate reservoir interval of the offshore Hasdrubal Field has a diagenetic history in which dolomitisation of micrite-rich facies has significantly enhanced reservoir quality. Using published information on the diagenetic evolution, digital textural representations of the limestones and dolostones are created using the Multi-Component Architecture Method (MCAM). This te

Northwestward shift of the northern boundary of the East Asian summer monsoon during the mid-Holocene caused by orbital forcing and vegetation feedbacks

The East Asian summer monsoon (EASM) northern boundary is a critical indicator of EASM variations. Movement of the boundary is modulated by both the EASM and the mid-latitude westerlies. Here, we use the Earth system model EC-Earth to quantify the contribution of orbital forcing and vegetation feedbacks in modulating the movement of EASM northern boundary. The results show that the simulated EASM

Drivers of the water use efficiency changes in China during 1982–2015

This study investigates the drivers of water use efficiency (WUE), a key metric of water resources management, and its changes over eight regions across China from 1982 to 2015 based on gross primary production (GPP) and actual evapotranspiration (AET) datasets. The order of seasonal change of WUE from large to small is autumn, summer, spring and winter. The drivers include seven variables, air te

Localised strain in fissured clays : The combined effect of fissure orientation and confining pressure

This paper reports the main results of an experimental study on the mechanics of intensely fissured natural clays, extending our previous studies on scaly clay from Santa Croce di Magliano. While previous work focused on the influence of the orientation of fissures with respect to the loading direction, the present investigation specifically explores an additional, important variable: the stress l

Faster and more accurate patient positioning with surface guided radiotherapy for ultra-hypofractionated prostate cancer patients

Introduction: The aim of this study was to evaluate if surface guided radiotherapy (SGRT) can decrease patient positioning time for localized prostate cancer patients compared to the conventional 3-point localization setup method. The patient setup accuracy was also compared between the two setup methods. Materials and methods: A total of 40 localized prostate cancer patients were enrolled in this

Predictors of Virologic Failure Among a Cohort of HIV-infected Children in Southern Ethiopia

BACKGROUND: Optimal care for children with HIV infection includes timely assessment of treatment failure. Using HIV viral load to define treatment failure remains a challenge in resource-limited settings.METHODS: Children with HIV infection who were already on or starting first-line antiretroviral therapy were enrolled and followed over time. We examined clinical and immunologic predictors of viro

Stigma matters in ending tuberculosis : Nationwide survey of stigma in Ethiopia

BACKGROUND: Tuberculosis (TB) affects, and claims the lives of, millions every year. Despite efforts to find and treat TB, about four million cases were missed globally in 2017. Barriers to accessing health care, inadequate health-seeking behavior of the community, poor socioeconomic conditions, and stigma are major determinants of this gap. Unfortunately, TB-related stigma remains unexplored in E

Patients present earlier and survival has improved, but pre-ART attrition is high in a six-year HIV cohort data from Ethiopia

BACKGROUND: Previous studies showed higher early mortality rates among patients treated with antiretroviral drugs in settings with limited resources. One of the reasons was late presentation of patients to care. With improved access to HIV services, we expect improvements in disease stage at presentation. Our objective was to assess the effect of improved availability of HIV services on patient pr

Comparative analysis of signal models for microscopic fractional anisotropy estimation using q-space trajectory encoding

Microscopic diffusion anisotropy imaging using diffusion-weighted MRI and multidimensional diffusion encoding is a promising method for quantifying clinically and scientifically relevant microstructural properties of neural tissue. Several methods for estimating microscopic fractional anisotropy (µFA), a normalized measure of microscopic diffusion anisotropy, have been introduced but the differenc

APOE4 affects basal and NMDAR mediated protein synthesis in neurons by perturbing calcium homeostasis

Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in humans - APOE2, APOE3, and APOE4. APOE4 is the most well-established risk factor increasing the pre-disposition for Alzheimer's disease. The presence of the APOE4 allele alone is shown to cause synaptic defects in neurons and recent studies have identified multiple pathways directly influenced by APOE4. How