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An important tool for understanding the biology of muscle-invasive bladder cancer (MIBC) is molecular subtype classification. Molecular subtypes are qualitatively distinct biological entities that can be identified by molecular analysis of tumor tissue. This chapter describes how such entities have been discovered and described for MIBC and gives an overview of the characteristics that the luminal
Marketing is an important function and practice in everyday business. It involves getting potential customers interested in a product or service through value-oriented arguments. In this way, marketing plays a pivotal role in driving the consumption of goods and services. Given the increasing consumption of goods and services, decreasing product lifetimes, and increasing levels of waste in all pro
The primary aim of this study is to estimate crop evapotranspiration (ETc) and develop a land use map to support the sustainable management of water resources in the irrigated Tassaout perimeter of Tensift. This is achieved by combining a time series of high spatial resolution Sentinel-2 satellite images, meteorological data, and field data. The method is based on the relationships between normali
Electric vehicles (EVs) are vital for a decarbonized society, but the rapid growth of the EV market highlights an impending lithium supply crisis. This study integrates supply-demand analysis with trade network simulations, using eight lithium demand scenarios and two supply scenarios to examine regional lithium dynamics and the impact of international trade. Results show that while domestic lithi
Introduction: Multidrug resistance (MDR) has been identified in wound bacterial isolates from Ukrainian war victims treated in Ukraine and across Europe. ILP100, a drug candidate for the treatment of skin wounds, is composed of a Limosilactobacillus reuteri expressing human chemokine CXCL12. In this study, the antimicrobial effects of ILP100 were tested on MDR bacteria isolated from wounds of Ukra
Genome-wide association studies (GWASs) in ancestrally diverse populations are rapidly expanding, opening up unique opportunities for novel gene discoveries and increased utility of genetic findings in non-European individuals. A popular technique to identify putative causal variants at GWAS loci is via statistical fine-mapping. Despite tremendous efforts, fine-mapping remains a very challenging t
Pruritus is a frequent symptom in medicine. Population-based studies show that one in five persons in the general population has suffered from chronic pruritus (CP) at least once in their lifetime, with a 12-month incidence of 7%. CP, which can affect all age groups, is associated with numerous, often interdisciplinary medical conditions. It needs a precise diagnostic work-up to identify causes an
The revised Payment Services Directive (PSD2) by the EU is disrupting banks and requiring them to provide third-party providers (TPPs) access to customer data. PSD2 aims to promote innovation and competition by enabling TPPs to leverage data to develop payment services. To comply, banks develop platforms where TPPs can use APIs to access data. This is described as open banking, marking a shift tow
The revised Payment Services Directive (PSD2) is reshaping traditional banking by requiring banks to grant licensed third-party providers (TPPs) access to customer data. This paper explores PSD2’s impact on Fintech market entry, assessing both opportunities and ongoing structural barriers. Through a qualitative investigation, it identifies key barriers such as API standardization gaps, data access
This thesis explores how teachers in Sweden’s art and music schools navigate the potentially conflicting goals of musical progress and social inclusion in group instrumental teaching. Group teaching has gained popularity due to cost-efficiency and its potential to meet children's social needs. However, many teachers trained in the one-to-one conservatory tradition express concern about maintaining
Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural
Time-frequency (TF) postprocessing methods are often used to form concentrated TF representations (TFRs) for nonstationary signals. Regrettably, most such techniques are sensitive to noise and tend to underestimate weak components when dealing with transient signals, resulting in sidelobes and low-resolution TFRs. In this work, we introduce a generalized group delay (GD) weighted sparse TF (GWSTF)
Background: Ultrafiltration (UF) insufficiency in peritoneal dialysis (PD) often leads to transfer to hemodialysis. Therefore, strategies to prolong time on therapy are needed. The use of a combined crystalloid and colloid solution, also called bimodal PD, can help improve UF. Methods: We propose a method for reconstituting bimodal solutions. Three bimodal PD solutions, with respectively 100 ml (s
The solute exclusion technique (SET) is often used to characterise the nano-porous structure of water-swollen cell walls. SET is based on the immersion of water-saturated wood samples in solutions of probe molecules of known size. Based on determined concentration differences in the solution before and after immersion, the accessible water within the wood is determined for each probe. However, thi
