Reactive oxygen species (ROS) are implicated in epithelial cell-state transition and deposition of extracellular matrix upon airway injury. Of the many cellular targets of ROS, oxidative DNA modification is a major driving signal. However, the role of oxidative DNA damage in modulation profibrotic processes has not been fully delineated. Herein, we report that oxidative DNA base lesions, 8-oxoG, c

Rapid changes in forces and the resulting changes in acceleration, jerk and higher order derivatives can have undesired consequences beyond the effect of the forces themselves. Jerk can cause injuries in humans and racing animals and induce fatigue cracks in metals and other materials, which may ultimately lead to structure failures. This is a reason that it is used within standards for limits sta

OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool vi

The biotechnology industry has recently been demanding second generation of nanoparticle byproducts such as viruses, plasmids, virus-like particles and drug-delivery assemblies (20-300 nm). The possibility of preparing uniform nanoparticles consisting of proteins such as gelatin followed by covalent linkage of avidin was investigated. Gelatin nanoparticles were prepared by two-step desolvation. As

This article purports to explain why the concept of global civil society recently has attracted so much interest within academic and political discourse. Given the ambiguity and apparent incoherence of this concept, its centrality within contemporary International Relations and political theory is puzzling. The article argues that once we pay attention to the function of the concept of domestic ci

Intermarriage between immigrants and native individuals highlights the need to study childbearing as a joint decision of couples, because fertility preferences are likely to differ for the two partners involved. This study focuses on Sweden, where the majority population holds a relative preference for daughters but many immigrants come from countries with son preferences. Using longitudinal regis

The forward lunge (FL) may be a promising movement to assess functional outcome after ACL reconstruction. Thus, we aimed to investigate the FL movement pattern before and after ACL reconstruction with a comparison to healthy controls to determine if differences were present. Twenty-eight ACL injured participants and 28 matched healthy controls were included. They performed FL movements while sagit

Background: Voluntary activation deficit of the quadriceps muscle group is a common symptom in populations with knee joint injury. Musculoskeletal modeling and simulations can improve our understanding of pathological conditions; however, they are mathematically complex which can limit their clinical application. A practical subject-specific modeling framework is introduced to evaluate knee extens

Soft tissue artefact (STA) represents one of the main obstacles for obtaining accurate and reliable skeletal kinematics from motion capture. Many studies have addressed this issue, yet there is no consensus on the best available bone pose estimator and the expected errors associated with relevant results. Furthermore, results obtained by different authors are difficult to compare due to the high v

Although many dopant-free hole transport materials (HTMs) for perovskite solar cells (PSCs) have been investigated in the literature, novel and useful molecular designs for high-performance HTMs are still needed. In this work, a hydrogen-bonding association system (NH···CO) between amide and carbonyl is introduced into the pure HTM layer. Our study demonstrates that the hydrogen-bonding associatio

This article investigates how geographical capital switching, precipitated by the 2007–08 economic crisis, has altered the strategic territorial organization of European city-regions. The dislocation of capital accumulation to (emerging) foreign markets has undermined the purported capacity for city-regions to regulate the contradictions of uneven development in the European Union. The argument is

Accurate visualization and understanding of liquid breakups and dynamics of liquid jets, sheets, blobs and ligaments is important for a wide range of spray applications. Here, temporally resolved 3D measurements are necessary to obtain the complete characterization these processes. The currently available 3D imaging techniques are usually based on time-averaged data and do not have the capability

Cesium lead iodide (CsPbI3) perovskite nanocrystals (NCs) suffer from a known transformation at room temperature from their red-emitting (black) to non-emitting (yellow) phase, induced by the tilting of PbI6 octahedra. While the reported attempts to stabilize CsPbI3 NCs mainly involve Pb2+-site doping as well as compositional and/or NC surface engineering, the black phase stability in relation onl

This article provides an insight into the world of Polish development workers operating in South Sudan. It shows that the conceptualisations of aid work in terms of a ‘mission’, a unique job with a special, ethical goal, a difficult, risky operation requiring specific skills are not incidental. Instead, the point is made, that such ways of thinking about foreign aid and distant locations are stron

Climate change is an urgent global issue affecting millions of people and several ecosystems. However, there is a significant gap between what has been done and what is needed for climate change adaptation. Conservation areas play a crucial role in responding to climate change by providing essential ecosystem services and supporting biodiversity and human adaptation. However, there is a lack of re

Vegetation indices derived from remotely sensed optical data are commonly used for crop monitoring in precision agriculture, but their information capability can be hindered by the presence of clouds. Consequently, areas with frequent cloud cover like the southwest of Sweden may have limited access to usable optical data. Nonetheless, the addition of synthetic aperture radar (SAR) data can provide

Enzymatic polyethylene terephthalate (PET) recycling processes are gaining interest for their low environmental impact, use of mild conditions, and specificity. Furthermore, PET hydrolase enzymes are continuously being discovered and engineered. In this work, we studied a PET hydrolase (PET2), initially characterized as an alkaline thermostable lipase. PET2 was produced in a fusion form with a 6-h