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The hereditary disease Retinitis pigmentosa results in severe vision loss due to photoreceptor degeneration by unclear mechanisms. In several disease models, the second messenger cGMP accumulates in the degenerating photoreceptors, where it may over-activate specific cGMP-interacting proteins, like cGMP-dependent protein kinase. Moreover, interventions that counteract the activity of these protein

Background: Despite the promising evidence of health-promoting and preventive interventions for maintaining health among older people, not all interventions can be implemented due to limited resources. Due to the variation of content in the interventions and the breadth of outcomes used to evaluate effects in such interventions, comparisons are difficult and the choice of which interventions to im

Experimental observation of 34Si as a proton bubble nuclei has heated up the interest in the study of exotic bubble shaped nuclei. In this work, some of the potential doubly bubble-like (for proton as well as neutron both simultaneously) cases have been explored using relativistic Hartree-Bogoliubov (RHB) in light mass region, specially around N or Z = 14. Further, the role of pairing and the evol

Aim: The purpose of this study was to investigate the psychometric properties of the EQ-5D-3L and the EQ-5D-5L in patients with back and neck pain. Materials and methods: Participants from two independent clinical survey studies was included in this study. In total 164 participants were answering either the EQ-5D-3L or the EQ-5D-5L after their visit to a physiotherapist in primary care for back an

This paper is intended to present the results of an experimental investigation upon the possibility of clay core replacement with fiber (polypropylene) reinforced concrete core in rock‐fill dams. Within the rock‐fill dams, usually clayey soil is used as the main core material of the whole structure. Due to the fact that this kind of soil, being used; would have caused many problems such as; a huge

Background and purpose — Obesity is a considerable medical challenge in society. We investigated the risk of revision for any reasons and for infection in patients having total knee arthroplasty (TKA) for osteoarthritis (OA) within 2 years after bariatric surgery (BS) and compared them with TKAs without BS. Patients and methods — We used the Scandinavian Obesity Surgery Registry (SOReg) and the Sw

BACKGROUND: This study aimed to investigate whether white matter lesions (WML), β-amyloid- and tau pathologies are independently associated with mobility, dual tasking and dynamic balance performance in older non-demented individuals.METHODS: We included 299 older people (mean, SD, age: 71.8, 5.6 years) from the Swedish BioFINDER study, whereof 175 were cognitively unimpaired and 124 had mild cogn

Ungulate prey can use increased vigilance to reduce their risk of predation, but little is known of the combined and interactive risk effects from humans and wolves in determining ungulate behaviour across time and space. Understanding the interplay between these risk effects is increasingly important, considering the recolonisation of several large carnivores to more human-dominated landscapes in

This paper examines how the moisture conditioning method affects the electrical conductance of wood. A widely used dataset was acquired by Stamm in 1929 who used a method of conditioning where water-saturated wood specimens were partially dried, sealed and left for a period of time for moisture to be redistributed before the electrical conductance was measured. However, more recent measurements co

SAMHD1 degrades deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA. Davenne et al. find that SAMHD1 protects cells against dNTP imbalances. Exposure of SAMHD1-deficient cells to deoxyguanosine (dG) results in increased intracellular dGTP levels and subsequent apoptosis. This can be exploited to selectively kill cancer cells that acquired SAMHD1 mutations.

Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re

Concrete is the most commonly used material worldwide, often associated with an irreversible production process and waste generation at the end-of-life. As such, the concrete industry holds large untapped potentials for moving towards more circular economy (CE) practices. Product service system (PSS) offerings incentivize CE through extending product use, improving product performance and developi

Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is bas

Progress in the power conversion efficiency of solar cells based on metal-halide perovskite semiconductors has been astonishing for the past years. During their development, transient effects have been observed that gave rise to an uncertainty associated with the determination of device performance from current density-voltage (J-V) measurements. This effect becomes visible in a dependence of the

In the wake of global crises concerning, for example, inequalities, migration, pandemics, and the environment, ethical concerns have come to the fore. In this thematic issue, we are especially interested in the role that the planning, design, and materialities of the built environment can take in relation to ethics, and we present four different openings or themes into urban ethics that we also th

This article aims to understand how the introduction of blue-green solutions affects ethical concerns and expectations of an urban environment. Blue-green solutions are complementary technical solutions, introduced into urban water management, in order to deal with the impact of urbanisation and climate change. These kinds of solutions establish new affordances that have an impact on everyday life

INTRODUCTION: The pituitary gland has a high expression of somatostatin receptors (SSTRs) and is therefore a potential organ at risk for radiation-induced toxicity after 177Lu-DOTATATE treatment.OBJECTIVE: To study changes in pituitary function in patients with neuroendocrine tumors (NETs) treated with dosimetry-based 177Lu-DOTATATE to detect possible late toxicity.METHODS: 68 patients from a phas

PURPOSE: Current hypothesis regarding the mechanism of active tear drainage is based on studies performed ex vivo or under nonphysiological conditions. Novel ultra-high-frequency ultrasound has the advantage of generating images with superior resolution, enabling measurements of low flow in small vessels, and the tracking of tissue motion in real time. The purpose of this study was to investigate