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Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.

BACKGROUND: The Tensin family of intracellular proteins (Tensin1, -2, -3 and -4) are thought to act as links between the extracellular matrix and the cytoskeleton, and thereby mediate signaling for cell shape and motility. Dysregulation of Tensin expression has previously been implicated in human cancer. Here, we have for the first time evaluated the significance of all four Tensins in a study of

Transitivity in discourse : A comparison of Greek, Polish and Swedish

Popular Abstract in Swedish Olika morfologiska former i olika språk antas bero på gemensamma kognitiva funktioner och semantiska egenskaper. En övergripande term för sådana semantiska egenskaper är transitivitet. Transitivitet yttrar sig bl.a. i aspekt hos verbet och bestämdhet hos objektet. En avgörande kognitiv funktion är för- och bakgrundsstruktur av information. Detta testas här empiriskt i (This work assumes that various linguistic forms in different languages are related to common cognitive functions and semantic properties. A cognitive function - presumably universal - is information transmission. The notion of interest is transitivity, which contains a set of semantic properties such as agentivity, dynamism, affectedness, boundedness and givenness, and the explicit forms are verb

FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia.

FYN is a non-receptor tyrosine kinase belonging to the SRC family of kinases, which are frequently over-expressed in human cancers, and play key roles in cancer biology. SRC has long been recognized as an important oncogene, but little attention has been given to its other family members. In this report, we have studied the role of FYN in FLT3 signaling in respect to acute myeloid leukemia (AML).

Dispersion relations for extinction of acoustic and electromagnetic waves

This thesis deals with physical limitations on scattering and absorption of acoustic and electromagnetic waves. A general dispersion relation for the extinction cross section of such waves is derived from the holomorphic properties of the scattering amplitude in the forward direction. The result states that for a given volume, there is only a limited amount of scattering and absorption available i

Impact of an Exercise Intervention on DNA Methylation in Skeletal Muscle From First-Degree Relatives of Patients With Type 2 Diabetes.

To identify epigenetic patterns, which may predispose to type 2 diabetes (T2D) due to a family history (FH) of the disease, we analyzed DNA methylation genome-wide in skeletal muscle from individuals with (FH(+)) or without (FH(-)) an FH of T2D. We found differential DNA methylation of genes in biological pathways including mitogen-activated protein kinase (MAPK), insulin, and calcium signaling (P

SADB phosphorylation of gamma-tubulin regulates centrosome duplication.

Symmetrical cell division requires duplication of DNA and protein content to generate two daughter cells. Centrosomes also duplicate during cell division, but the mechanism controlling this process is incompletely understood. We describe an alternative splice form of SadB encoding a short SADB Ser/Thr kinase whose activity fluctuates during the cell cycle, localizes to centrosomes, and controls ce

Staphylococcus aureus and Squamous Cell Carcinoma of the Skin.

Squamous cell carcinoma (SCC) of the skin is a tumor with greatly increased incidence among immunosuppressed patients; therefore, an infectious cause of SCC has long been sought. We performed a hospital-based case-control study of Staphylococcus aureus and biopsies of SCC (n = 82), basal cell carcinoma (n = 142), actinic keratosis (n = 57), and seborrhoeic keratosis (n = 72) in comparison with bio

Long-term suicide risk of depression in the Lundby cohort 1947-1997 - severity and gender.

Objective: The long-term suicide risk of depression was evaluated in a community sample by severity and gender. Method: The Lundby study is a prospective, longitudinal cohort study on a population consisting of 3563 subjects. In 1947-1997 medium or severe depression according to the Lundby diagnostic system were registered in 503 subjects. The same subjects were also diagnosed according to DSM-IV