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Objectives: To use a population pharmacokinetic approach to define maximally effective meropenem dosing recommendations for treatment of Acinetobacter baumannii and Pseudomonas aeruginosa infections in a large cohort of patients with septic shock. Methods: Adult patients with septic shock and conserved renal function, treated with meropenem, were eligible for inclusion. Seven blood samples were co
Purpose: We describe a public dataset with MR and CT images of patients performed in the same position with both multiobserver and expert consensus delineations of relevant organs in the male pelvic region. The purpose was to provide means for training and validation of segmentation algorithms and methods to convert MR to CT like data, i.e., so called synthetic CT (sCT). Acquisition and validation
Background: Congestive heart failure (CHF) is a serious complication in patients with atrial fibrillation (AF). Objective: To study associations between relevant co-morbidities and CHF in patients with AF. Methods: Study population included all adults (n = 12,283) ≥45 years diagnosed with AF at 75 primary care centers in Sweden 2001-2007. Logistic regression was used to calculate odds ratios with
This chapter discusses the increasing tendency to remove street art from its original site for personal gain. It further explores whether/how copyright claims can be an effective means of preventing such extractions.
Hos friska kvinnor är akut cystit besvärande men ofarligt. Infektionen läker spontant, behandling förkortar tiden med symtom och ges i symtomlindrande syfte. Akut cystit är en bakteriell infektion i urinblåsans slemhinna och definieras som nytillkommen sveda, trängningar och ökad frekvens till vattenkastning samtidigt med bakterier i urinen. Diagnostiken i primärvården baseras framför allt på klin
Relationships between health professionals and pharmaceutical manufacturers can unduly influence clinical practice. These relationships are the focus of global transparency efforts, including in Europe. We conducted a descriptive content analysis of the transparency provisions implemented by February 2017 in nine European Union countries concerning payments to health professionals, with duplicate Relationships between health professionals and pharmaceutical manufacturers can unduly influence clinical practice. These relationships are the focus of global transparency efforts, including in Europe. We conducted a descriptive content analysis of the transparency provisions implemented by February 2017 in nine European Union (EU) countries concerning payments to health professionals, with dupli
Jordbruksmodernisering har dramatiskt ökat tillgången till mat på global nivå, men till ett högt pris för miljön. Idag efterlyser många ett ’paradigmskifte’ i jordbruket, även flera stora mainstream-institutioner. Med ett skifte till vad? Under senare år har det synts en ökande tilltro till agroekologi, ett alternativ som syftar till att förstå och bedriva jordbruk som komplexa agroekosystem. FrånAgricultural modernization has massively increased global food supply, but at a high environmental cost. Today many are calling for an agricultural ‘paradigm shift’, including several mainstream institutions. But to what? In recent years, agroecology has gained credence as an alternative approach that seeks to understand and manage farms as complex agroecosystems. From a development perspective, i
Researchers from Sweden (IIIEE, Lund University) and the US (Enervee) have found that minimum energy per-formance standards (MEPS) for home appliances are an effective alternative to stand-alone carbon pricing. A modest tightening of MEPS is already sufficient to account for climate externalities. For several appliances, carbon prices would have to increase manifold to provide the same incentives
Due to their unique physical and material properties, III-Sb nanowires are considered good candidates for future devices, and test beds for understanding fundamental physics. Synthesizing these nanowires however is associated with certain challenging aspects, which are generally not present for other III-V nanowires, demanding the need for in depth investigations. For instance, growing Au-seeded I
The population of brain pericytes, a cell type important for vessel stability and blood brain barrier function, has recently been shown altered in patients with Alzheimer's disease (AD). The underlying reason for this alteration is not fully understood, but progressive accumulation of the AD characteristic peptide amyloid-beta (Aβ) has been suggested as a potential culprit. In the current study, w
This text sheds light on the delicate practice of including different religious as well as nonreligious expressions in a shared room. The effects of design decisions in a “room of silence” at a Swedish hospital are studied over a transitional period of renovation of the space. We observe the impact of materiality in the room’s establishment, renovation, and usage, and show how the room’s interior
Till skillnad från Ulibarrí är Sender en väldigt känd författare. Båda träffades i USA efter att denne flydde från Francos diktatur. Den här artikeln handlar om båda författarnas skönlitterära produktion under Senders exilår i USA.
The primary objective of this study is to compare the accuracy of two risk models, International Heart Transplantation Survival Algorithm (IHTSA), developed using deep learning technique, and Index for Mortality Prediction After Cardiac Transplantation (IMPACT), to predict survival after heart transplantation. Data from adult heart transplanted patients between January 1997 to December 2011 were c
We establish a connection between trend filtering and system identification which results in a family of new identification methods for linear, time-varying (LTV) dynamical models based on convex optimization. We demonstrate how the design of the cost function promotes a model with either a continuous change in dynamics over time, or causes discontinuous changes in model coefficients occurring at
