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In this work we introduce a new method for the construction of minimal submanifolds of codimension two in even dimensional spheres and hyperbolic spaces. This is based on the theory of complex-valued harmonic morphisms. This gives the first explicit examples of such maps defined on the sphere S^4 and the hyperbolic space H^4.
This chapter reviews and critically examines the evolution of systemic conceptual perspectives on energy innovation. It argues that energy innovation is by definition a systemic innovation problem, which cannot be adequately depicted with linear or chain-linked innovation models. It rather depends on complex and interrelated changes in technologies, actor networks and institutional arrangements, w
Importance Biological staging of Alzheimer disease (AD) can improve diagnostic accuracy and prognostic assessment. However, existing approaches often require invasive procedures and specialized infrastructure, limiting their routine clinical use. Objective To develop and validate a plasma-based biological staging model that closely mirrors an amyloid and tau positron emission tomography (PET)–base
Background: According to the World Health Organization, all healthy pregnant women are recommended to engage in at least 150 min of regular moderate-intensity aerobic activity per week. This level of physical activity is associated with numerous physical and psychological health benefits and helps to reduce the risk of being overweight, gestational diabetes, and preeclampsia. Despite its importanc
Sodium chloride (NaCl) has been proposed as a retrospective and prospective dosemeter for optically stimulated luminescence (OSL) dosimetry. The potential for NaCl pellets for individualised in situ dose assessment during a radiological or nuclear emergency was enhanced by their suitability with a portable OSL reader. The current paper studies the possibility of developing a public dosimetric badg
Trust is widely recognised as an important determinant of lending relationships, yet existing finance literature typically treats trust as a single construct and rarely examines how different trust dimensions operate across financial contracts with distinct risk structures. Our research addresses this gap by distinguishing between competence-based trust (perceived managerial capability) and value-
Amyloid deposition is a hallmark of numerous age-related diseases, and understanding the chemical mechanisms that govern amyloid formation is crucial for advancing the rational development of protein aggregation inhibitors. With amyloid formation rates varying widely across proteins, here we report the quantitative aggregation mechanism of medin, the most common localized amyloid in humans, and fi
Time-dependent diffusion MRI enables the estimation of water exchange rates in vivo. Most studies attribute these estimates to membrane permeability. However, non-permeative geometric exchange may also contribute. The present study investigates the contribution of geometric exchange between dendritic spines and shafts to diffusion MRI-derived exchange estimates. Monte Carlo simulations were perfor
Den ökande åldern hos brobestånden världen över kräver en systematisk utvärderingav deras säkerhet och en uppskattning av deras återstående livslängd. Samtidigtmedför strävan efter hållbarhet och kostnadseffektivitet att infrastrukturförvaltarebehöver förlänga användningen av befintliga konstruktioner och därigenom minskautsläppen av växthusgaser samt optimera användningen av ekonomiska resurser.FThe growing age of bridge inventories worldwide demands a systematic evaluation of their safety and estimation of their remaining service life. At the same time, the pursuit of sustainability and cost efficiency compels infrastructure managers to prolong the use of existing structures, thereby reducing greenhouse gas emissions and optimising financial resources. To achieve these objectives, assess
Objectives: FLASH radiotherapy is an innovative technique that delivers radiation at ultra-high dose rates (UHDR), offering tumor control comparable to conventional (CONV) radiotherapy while significantly reducing normal tissue toxicity. Here we aim to determine the effects of FLASH compared to CONV radiotherapy in muscle-invasive bladder cancer (MIBC) models. Methods: Using an in-house 6 MeV line
Aims: To describe healthcare professionals’ interactions with pediatric patients at an adult ICU. Methods: This non-participant naturalistic observational study was conducted at two adult ICUs in Sweden. Inclusion criteria were children aged 0–15 years, where both the child and the parent could speak and understand Swedish or English. Children undergoing palliative care were excluded. The observat
This study presents a multidisciplinary analysis of 119 osseous and ivory fragments from the necropolis of La Beleña (Córdoba, Spain) dating between the second half of the 4th and the beginnings of the 3rd Millennium BC, aiming to assess the effectiveness and limitations of current methods used for identifying ivory provenance in prehistoric contexts. Traditional macroscopic and microscopic techni
BACKGROUND: Obesity is a major risk factor for heart failure (HF). However, individuals with similar body mass index (BMI), the main diagnostic measure of obesity, exhibit considerable heterogeneity in developing HF.OBJECTIVES: This study aimed to investigate the association between metabolically discordant subgroups characterized by cardiometabolic biomarkers deviated from those predicted by BMI
BACKGROUND: The EAT-Lancet Commission introduced the planetary health diet to promote human health while reducing environmental impact. However, no study has yet examined how adherence to this diet is associated with risk of irritable bowel syndrome (IBS).OBJECTIVE: This study aimed to investigate the association between the planetary health diet index (PHDI) and the risk of developing IBS.METHODS
BACKGROUND: Physical activity (PA) has well-documented cardio-respiratory protective effects in individuals with lung diseases. Whilst most studies examining the relationship between PA, lung function and respiratory symptoms have included self-reported PA data, studies assessing PA objectively using accelerometers are scarce.AIM: To explore the association of sedentary behavior (SED) and moderate
Seasonality can drive the evolution of reproductive plasticity in insects. An extreme form is reproductive diapause, where individuals halt reproduction during unfavourable seasons. How diapause evolves from milder forms of plasticity (e.g., through changes in cue perception and responses) is poorly understood. In the tropics, seasonality is common, but it is unclear how widespread reproductive pl
Bimanual motor performance declines with age and is accompanied by cortical thinning and alterations in white matter microstructure within motor control networks. Aging is also associated with increased interindividual variability in behavioral and structural markers, and some studies report stronger brain-behavior associations in older compared with younger adults. We tested whether bimanual perf
