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Lineage tracing of stem cell-derived dopamine grafts in a Parkinson's model reveals shared origin of all graft-derived cells

Stem cell therapies for Parkinson's disease are at an exciting time of development, and several clinical trials have recently been initiated. Human pluripotent stem cells are differentiated into transplantable dopamine (DA) progenitors which are proliferative at the time of grafting and undergo terminal differentiation and maturation in vivo. While the progenitors are homogeneous at the time of tr

Control of Capacity-Constrained Networks

This thesis concerns control of capacity-constrained networks. These systems involve many agents interconnected by a resource distribution network. The capacity to generate and distribute this resource is constrained. This applies, for instance, to power grids, communication networks, smart surveillance camera networks, and district heating networks. District heating networks in particular are the

Recovery of Soil Microbial Metabolism After Rewetting Depends on Interacting Environmental Conditions and Changes in Functional Groups and Life History Strategies

Climate change is causing an intensification of soil drying and rewetting events, altering microbial functioning and potentially destabilizing soil organic carbon. After rewetting, changes in microbial community carbon use efficiency (CUE), investment in life history strategies, and fungal to bacterial dominance co-occur. Still, we have yet to generalize what drives these dynamic responses. Here,

Boat Tours NHZ (New Harbour Zones) : Performance designed around a harbour tour in the Copenhagen harbour.

Performance designed around a harbour tour in the Copenhagen harbour. The concept, idea and staging was done by Erik Pold and Adelaide Bentzon, the artistic directors of Public Performance. 5 performers where the main characters in the boat or along the harbour, together with 20 extras, and live electronic music. The performance takes a critical view on how the contemporary harbour area has develo

Complex Regional Pain Syndrome : A cross-sectional study of physical symptoms, disability, and psychological health in long term

Introduction:Knowledge about long-time residual symptoms, disabilities, and psychological health in complex regional pain syndrome (CRPS) is limited.Objectives:The aim was to evaluate outcome, focusing on physical symptoms, disability, and psychological health, in individuals with CRPS through a cross-sectional survey study.Methods:Individuals with a confirmed diagnosis of CRPS were identified thr

Effective uniaxial dielectric function tensor and optical phonons in (2 ¯ 01)-oriented β - Ga2 O3 films with equally distributed sixfold-rotation domains

Monoclinic β-Ga2O3 films grown on c-plane sapphire have been shown to exhibit six (2¯01)-oriented domains, which are equally spaced by rotation around the surface normal and equally sized by volume that render the film optical response effectively uniaxial. We derive and discuss an optical model suitable for ellipsometry data analysis of such films. We model mid- and far-infrared ellipsometry data

Vävnader uppåt väggarna : Hemslöjdspionjären Lilli Zickerman i Vittsjö

Hemslöjdspionjären Lilli Zickerman (1858–1949), som tog initiativ till bildandet av Föreningen för svensk hemslöjd, var under nära fyra decennier bosatt i Vittsjö. Det var därifrån som hon tillsammans med flera familjemedlemmar, som också flyttat dit, arbetade med en stor inventering av svensk folklig textilkonst. Inventeringsmaterialet, som bär namnet ”Föreningen för svensk hemslöjds samlingsverk

The polar protein α-synuclein - An electrifying journey from chaos to order

The accumulation of amyloid fibrils from the protein 𝛼-synuclein is a pathological hallmark of Parkinson´s disease. 𝛼-synuclein is a highly polar protein with a remarkable primary structure that can be divided into three regions: the slightly basic N-terminal region, a central hydrophobic region, and a highly acidic C-terminal tail. The C-terminal tail is of specific focus in this thesis. A chan

Fire safety separation distances between camping units and caravans

Almost 20 years ago, MSB's representatives published general advice and comments on fire protection at camping facilities (SRVFS2004:12). However, this is considered general advice and is not technically mandatory. This advice is linked to 2 kap. 2 § of the Act (2003:778) on protection against accidents, which in this case points out an obligation for owners and users of camping facilities to main

Classic Grounded Theory: A Rigorous Methodology for Research Involving Participants With Severe/Profound Intellectual Disabilities : A Discussion of Classic Grounded Theory as a Way of Undertaking Rigorous, Credible Research Involving Participants With Severe/Profound Intellectual Disability

Background: Including people with severe/profound intellectual disabilities as research participants challenges researchers due to their diverse abilities to participate and express themselves. Ensuring the rigour of the research and the credibility of the findings presents a challenge.Methods: We use examples from our research to demonstrate that Classic Grounded Theory offers a systematic but fl

A Cross-Sectional Study of Circadian Stimulus in Swedish Radiographers’ Light Environment

Timely light exposure is a vital aspect to achieve better sleep and well-being. As there are risks with a disturbed circadian rhythm and benefits with light settings that stimulate the rhythm, the circadian effective light, circadian stimulus (CS), for radiographers was examined. Aim: The aim of the study was to compare radiographers’ light environment on the workstations, at a university hospital

Central characteristics and critical success factors of design thinking for product development in industrial SMEs : a bibliometric analysis

Design thinking is an innovative methodology that may be applied by small and medium enterprises which emphasizes a human-centered approach to problem-solving, facilitating the creation of novel solutions for complex and open-ended challenges like the development of new products. Despite its recognized importance in business and academia, many industrial SMEs struggle with applying design thinking

Creating temporal and spatial connections through and with co-costumed entanglements

This Critical Costume exhibition presentation derives from the twelve-hour costume-based ‘performative-walk’ Community Walk (2020). The frame for Community Walk was a bright yellow costume that physically connected two wearers. In Community Walk I, the researcher and costume designer, placed myself ‘in the centre’ of the co-wearing entanglements. For twelve hours I co-wore the costume in the centr

Depth-Resolved X-Ray Photoelectron Spectroscopy Evidence of Intrinsic Polar States in HfO2-Based Ferroelectrics

The discovery of ferroelectricity in nanoscale hafnia-based oxide films has spurred interest in understanding their emergent properties. Investigation focuses on the size-dependent polarization behavior, which is sensitive to content and movement of oxygen vacancies. Though polarization switching and electrochemical reactions is shown to co-occur, their relationship remains unclear. This study emp

Lipids and apolipoproteins and the risk of vascular disease and mortality outcomes in women and men with type 2 diabetes in the ADVANCE study

Aim: Whether apolipoproteins (apolipoprotein A1, apolipoprotein B, apolipoprotein B/apolipoprotein A1 [ApoB/ApoA1] ratio) or very-low-density lipoprotein (VLDL) cholesterol are better risk predictors than established lipid risk markers, and whether there are sex differences, is uncertain, both in general populations and in patients with diabetes. The aim of this study was to assess the association

Microbiome Geographic Population Structure (mGPS) Detects Fine-Scale Geography

Over the past decade, sequencing data generated by large microbiome projects showed that taxa exhibit patchy geographical distribution, raising questions about the geospatial dynamics that shape natural microbiomes and the spread of antimicrobial resistance genes. Answering these questions requires distinguishing between local and nonlocal microorganisms and identifying the source sites for the la