Popular Abstract in Swedish HIV består av två besläktade virusvarianter, HIV-1 och HIV-2. Båda kan orsaka uttalad immunbrist (AIDS) hos drabbade individer, men detta sker långsammare vid HIV-2. HIV-1 är viruset som orsakat den globala HIV epidemin medan HIV-2 främst hittas i Västafrika. HIV infekterar kroppens immunceller genom att binda till vissa äggviteämnen på cellytan. Efter inbindning till CHIV-1 infection of CD4+ immune cells requires the assistance of cellular coreceptors. The regulation of these receptors is highly dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. Compartmentalized HIV-1 infection of the central nervous system (CNS) m

Interference among predators decreases per capita foraging rates and has implications for both community dynamics and top-down trophic processes. Interference originates from behavioural interactions among foragers, and these behaviours could be affected by environmental conditions. In experiments on pike foraging alone or among conspecifics in different levels of water turbidity, we expected high

Heparan sulfate (HS), a substance common in the extracellular matrix on epithelial cells is present in the pancreas, lining the duct lumen. During pathological conditions, we propose that it can be shed from the ECM and bind to receptors on the cell surface, thus triggering an inflammatory response, which if excessive can cause acute pancreatitis (AP). Infusion of HS in the pancreatic duct in rats

This study explores the differences in oral narrative skills between school-age children with mild-to-moderate sensorineural hearing loss (HL) and children who have typical hearing and language development. Narrative samples were collected following a picture-elicited storytelling task. Language samples were transcribed and coded for a number of measures, including narrative content, syntax, and g

With aging, the incidence of falls and fractures increases. There has during the last decades been secular changes in demographics so that the proportion of elderly increases in society. Hence, there is an increasing need for clinicians to be able to make a solid appraisal of the elderly patient's functional capacity, as to identify individuals with an increased risk to fall. If high risk individu

1. Permutation tests are important in ecology and evolution as they enable robust analysis of small sample sizes and control for various forms of dependencies among observations. A common source of dependence is spatial autocorrelation. Accounting for spatial autocorrelation is often crucial, because many ecological and evolutionary processes are spatially restricted, such as gene flow, dispersal,

Tasquinimod is an orally active antiangiogenic drug that is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. However, the target of this drug has remained unclear. In this study, we applied diverse strategies to identify the histone deacetylase HDAC4 as a target for the antiangiogenic activity of tasquinimod. Our comprehensive analysis revealed allo

Professional cycling combines extensive endurance training with non weight-bearing exercise, two factors often associated with lower bone mineral density (BMD). Therefore BMD was measured with dual-energy x-ray absorptiometry in 30 professional road cyclists (mean (SD) age: 29.1 (3.4) years; height: 178.5 (6.7) cm; weight: 71.3 (6.1) kg; %fat mass: 9.7 (3.2)%; (V) over dotO(2) max: 70.5 (5.5) ml .

Popular Abstract in Swedish Varje år insjuknar ca 7000 kvinnor i Sverige i bröstcancer och antalet ökar för varje år. Fortfarande är kunskapen om orsakerna till bröstcancer relativt okända, men många av de kända riskfaktorerna är kopplade till en hög halt av könshormoner i blodet. Faktorer i kosten som kan motverka effekten av könshormonerna är därför av stort intresse. Under 1990-talet inbjöds Diets high in fibre have previously been associated with decreased risk of breast cancer in the Malmö Diet and Cancer cohort. Several potent compounds may exist in high-fibre diets that might protect against breast cancer, for example lignans. Plant lignans are converted to enterolactone by the gut microflora and are similar in structure to estrogens. Enterolactone may interact with the estrogen r

Although chemical functionalization of single-walled carbon nanotubes was extensively studied, in many cases detailed information about the influence of the nanotube metallicity and diameter is missing. Here, we present an X-ray photoemission and absorption spectroscopy study of endohedrally functionalized carbon nanotubes with different diameters, where Ni(II) acetylacetonate molecules are reacte

ABSTRACT: Courses of Parkinson's disease (PD) that are complicated by weight loss result in poorer overall treatment outcome and lower quality of life. To determine the contribution of depression, which has not yet been specified in the etiology of weight loss in PD, symptomatology and anamnesis from 215 outpatients diagnosed with PD were assessed using a comprehensive battery of neuropsychiatric

This study uses Swedish accident data for the years 2004–2008 to analyze the relationship between injury severity for pedestrians struck by a vehicle and the speed environment at accident locations. It also makes use of a multinomial logit model and other statistical methods. Speed measurements have been performed at accident sites, and the results show that there was a relationship between the (1

Fotosyntesen är växternas fantastiska och för oss livgivande metod att med hjälp av energin i solljuset omvandla luftens koldioxid till växtbiomassa och syre. Men många lägre organismer har en fotosyntes som inte producerar nŒgot syre, medan åter andra organismer kan binda koldioxid med hjälp av någon annan energikälla än solljuset. Lars Olof Björn och Jan Bergström reder ut begreppen.

Although large-scale prospective cohort studies have related hyperglycemia to increased risk of cancer overall, studies specifically on colorectal cancer have been generally small. We investigated the association between prediagnostic levels of glycosylated hemoglobin (HbA1c), a marker for average glucose level in blood, and colorectal cancer risk in a case-control study nested within the European

Background. The acronym ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations) highlights that children seeking clinical treatment are often multiply impaired, thus requiring treatment from several specialties. The aim was to map and relate, on a population level, ESSENCE to two salient predictors of health and adaptation to adversities, namely, Self-Directedness