Kinetic properties of the monomeric enzyme dUTPase from herpes simplex virus type 1 (HSV) were investigated and compared to those previously determined for homotrimeric dUTPases of bacterial and retroviral origins. The HSV and Escherichia coli dUTPases are equally potent as catalysts towards the native substrate dUTP with a kcat/KM of about 107 M-1 s-1 and a KM of 0.3 μM. However, the viral enzyme

BRCA1 mutations, although implicated in disease predisposition in a major part of the hereditary breast cancer population, do not seem to be crucially involved in tumorigenesis of sporadic breast and ovarian cancers. This suggests that tumours arising in BRCA1 mutation carriers may differ from BRCA1 negative hereditary and sporadic cancer in genetic and biological features, as well as in clinical

We construct hadronic potentials that describe the spectrum and decays of electromagnetic bound states of hadrons, and are consistent with Chiral Perturbation Theory. This procedure enables one to clarify the status of the calculations-based on potential models-of the electromagnetic corrections to the observables of hadronic atoms and to the strong scattering amplitudes at low energy.

We report on the visualization of the penetration of sunscreen formulations containing TiO2 nanoparticles (about 20 nm primary particle size) into hair follicles of both human and porcine skin using the complementary methods of ion microscopy (PIXE, RBS, STIM) and autoradiography. Particles were found as deep as approx. 400 pin in the follicle, obviously introduced mechanically rather than by a di

We report on large-scale ab initio calculations for intercombination lines in Si I-like ions. Two measurable quantities, the lifetime of the 3s3p(3 5)S(2) level and the branching ratio of the two lines are discussed, to infer the importance of different features of our calculations. The effects of core polarization, two-body spin-dependent operators and Dirac contra Breit-Pauli approaches are disc

Objective. Accurate and reproducible assessment of myocardial infarction is important for treatment planning in patients with ischemic heart disease. This study describes a novel method to quantify myocardial infarction by semi-automatic delineation of hyperenhanced myocardium in delayed contrast enhanced (DE) magnetic resonance (MR) images. Design. The proposed method automatically detects the hy

A search for excited electron (e*) production is described in which the electroweak decays e* --> egamma, e* --> eZ and e* ---> nuW are considered. The data used correspond to an integrated luminosity of 120 pb(-1) taken in e(+/-)p collisions from 1994 to 2000 with the H1 detector at HERA at centre-of-mass energies of 300 and 318 GeV. No evidence for a signal is found. Mass dependent exclusion lim

The concept of electronic tongues or taste sensors has developed rapidly during recent years due to their large potential. They are based on electrochemical sensors combined with multivariate data analysis. Voltammetric electronic tongues have proven valuable in many applications. Due to their ruggedness and simplicity, they have been found especially suitable for on-line monitoring of industrial

We published recently an integrated procedure for applying chemical marker analysis to characterize the microbiology of indoor environments comprising a scheme for extraction and analysis of markers of endotoxin, peptidoglycan/bacterial biomass, and fungal biomass. In the present paper, we report some significant improvements and also new possibilities of the described approach. We found that whil

In this study, we introduce the architecture and style of sedimentation of two outwash fans in front of the Myrdalsjokull ice cap, central south Iceland, that broaden different types of ice-marginal sedimentation. At Kotlujokull, a southeastern outlet of the ice cap, fan formation was monitored from the late 1970s to 2002; thus, the style of sedimentation is well understood and the relationship to

Popular Abstract in Swedish Moraxella catarrhalis är en bakterie som tillhör vår normala bakterieflora. Den är dock också en luftvägspatogen som kan orsaka öroninflammation hos barn, nedre luftvägsinfektioner hos vuxna och äldre, och bihåleinflammation hos både barn och vuxna. Intresset kring M. catarrhalis som patogen har ökat de senaste 20 åren, både på grund av ökat antal insjuknande personer oMoraxella catarrhalis is a respiratory tract pathogen that causes significant health problems, including acute otitis media in children, lower respiratory tract infections in adults and the elderly and sinusitis in both children and adults. The interest in M. catarrhalis bacteria has increased over the past 20 years, both because of the emergence of the bacteria as a human pathogen and because of

A new reduced-complexity Schnorr-Euchner decoding algorithm is proposed in this letter for uncoded multi-input multi-output systems, with q-QAM (q = 4, 16....) modulation. Furthermore, a Fano-like metric bias is introduced to the algorithm from the perspective of sequential decoding, as well as an early termination technique. Simulation results show that these modifications reduce the algorithm co

Background: TNF alpha is a cytokine that may contribute to the pathophysiology of airway inflammation. Inhalation of TNF alpha produces granulocyte recruitment and airway hyperresponsiveness in man. Anti-TNF alpha treatment may inhibit allergen-induced plasma exudation in guinea-pig airways. Increased nasal mucosal output of TNF alpha has been demonstrated in allergic rhinitis, but the effect of T

The first results from a series of experiments focused on the study of the internal structure of nuclei at the extremes of N:Z ratio using isomer spectroscopy are reported. These experiments represent the first of the Stopped Beam section of the Rare Isotopes Investigations at GSI (RISING) project. Exotic nuclei were synthesized using relativistic projectile fragmentation of similar to 500 -> 1000

Popular Abstract in Swedish Denna avhandling är resultatet av ett doktorandprojekt vid Kvartärgeologiska avdelningen, Lunds Universitet. Syftet med undersökningen var att rekonstruera vegetations- och klimatförändringar under de senaste 10 000 åren i Torneträskområdet i norra Sverige. Resultatet bygger på analyser av pollen och växtmakrofossil från 6 sjöar belägna på olika höjd över havet (370-999The aim of this study was to reconstruct the Holocene vegetation history and the climate changes in a subarctic area. The results are based on pollen and macrofossil records from six lakes in the Torneträsk area. The lakes are situated at altitudes between 370 and 999 m a.s.l., along a transect from the boreal pine-birch forest to the alpine tundra with heath vegetation. The chronology in each lak