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BACKGROUND: Interventions aimed at reducing the number of smokers are generally believed to be cost effective. However as the cost of the interventions should be paid up front whereas the gains in life years only appear in the future--the budgetary consequences might be a barrier to implementing such interventions. AIMS: The aim of the present paper was to assess the long-term cost effectiveness

I flera andra europeiska länder har antalet elektriska cyklar ökat kraftigt de senaste åren. En liknande ökning förväntas också i Sverige. Hittills har kunskapen om attityder hos elcyklister i Sverige varit begränsade. Denna studie består av intervjuer med 39 personer från hela Sverige för att få en bättre förståelse för varför de har valt att cykla en elcykel, och vad de tror kan göras för att få

Catchment export of terrestrial dissolved organic matter (DOM) and its downstream degradation in aquatic ecosystems are important components of landscape scale carbon balances. In order to assess the influence of peatland permafrost on river DOM characteristics, we sampled 65 rivers along a 900 km transect crossing into the southern discontinuous permafrost zone on the Boreal and Tundra Plains of

Electricity prices are known to spike during peak hours, only to revert to normal levels during off-peak hours. We introduce a generalization of the time varying independent spike model commonly used to model the electricity spot price from daily data to hourly data to cope with this feature. We let the probability of extreme prices depend on several variables, such as consumption, reserve margin

The effect of the antibiotic sulfamethoxazole (SMX) on soil bacteria was studied using two methods (leucine incorporation and Biolog plates) of estimating pollution-induced community tolerance (PICT). SMX was added to an agricultural soil in a microcosm setup. The addition of different substrates (manure and alfalfa), and a non-amended soil, were also studied over 5 weeks. PICT measurements were v

A measurement of jet shapes in top-quark pair events using 1.8 fb(-1) of pp collision data recorded by the ATLAS detector at the LHC is presented. Samples of top-quark pair events are selected in both the single-lepton and dilepton final states. The differential and integrated shapes of the jets initiated by bottom-quarks from the top-quark decays are compared with those of the jets originated by

Perivascular adult stem cells have been isolated from several tissues, including the adult human brain. They have unique signatures resembling both pericytes and mesenchymal stem cells. Understanding the nature of these cells in their specific vascular niches is important to determine their clinical potential as a new adult stem cell source. Indeed, they have promising features in vitro in terms o

Endosomal entrapment is known to be a major bottleneck to successful cytoplasmic delivery of nucleic acids (NAs) using cationic liposome-NA nanoparticles (NPs). Quantitative measurements of distributions of NPs within early endosomes (EEs) have proven difficult due to the sub-resolution size and short lifetime of wildtype EEs. In this study we used Rab5-GFP, a member of the large family of GTPases

In this study, we demonstrate that articular cartilage chondrocytes are surrounded by the defining basement membrane proteins laminin, collagen type IV, nidogen and perlecan, and suggest that these form the functional equivalent of a basement membrane. We found by real-time PCR that mouse chondrocytes express these four cardinal components of basement membranes and demonstrated by immunohistochemi

Accurate accelerator mass spectrometry (AMS) measurements rely on standards with well-known isotopic ratios. For radiocarbon measurements, a number of standards with different properties are commercially available, of which the IAEA-C6 sucrose standard with a 14C value of 150.61 pMC is the most active. When analyzing biological samples resulting from studies using 14C-labeled substances, the activ

We theoretically analyze optical forces on aggregates of metal nanoparticles in a focused Gaussian beam by extending the generalized Mie theory, which includes higher order multipoles and retardation effects. For two interacting metallic particles, an attractive gradient force, mainly caused by multipole plasmon excitation, exists at short interparticle distances, while induced dipolar fields domi

Ecological interactions between microparasite populations in the same host are an important source of selection on pathogen traits such as virulence and drug resistance. In the rodent malaria model Plasmodium chabaudi in laboratory mice, parasites that are more virulent can competitively suppress less virulent parasites in mixed infections. There is evidence that some of this suppression is due to

Feminist geographers use the term diasporic subjectivity to emphasize the relational quality of identity as it is constructed in the dynamic in-between space occupied by the migrant and traversed by norms and practices associated with the village community, migrant peers, and urban consumer society, as well as nation-states. Using ethnographic methods, I explore how young, single rural Chinese wom

Dietary fibre and whole grains are recommended to prevent the development of type 2 diabetes. Low glycaemic index foods that are rich in fibre are recommended to control blood glucose levels. Gastric emptying, together with other factors, regulate the postprandial blood glucose response. A delay in the gastric emptying rate (GER) leads to a lower postprandial blood glucose concentration. However,

Phosphorylation of estrogen receptor alpha at serine 305 (ER alpha S305-P) by protein kinase A (PKA) or p21-activated kinase 1 (PAK1) has experimentally been associated with tamoxifen sensitivity. Here, we investigated the clinical application of this knowledge to predict tamoxifen resistance in ER-positive breast cancer patients. Using immunohistochemistry, a score including PAK1 and co-expressio

Popular Abstract in Swedish Sambandet mellan exponering för miljögifter och mineraler i fosterlivet och risken att ha ADHD diagnos i barndomen ADHD (uppmärksamhetsstörning med hyperaktivitet) är en neuropsykiatrisk funktionsnedsättning som drabbar barn och kan fortsätta till vuxen ålder. Antalet barn som diagnosticerats med ADHD har ökat under senare år. Om detta beror på att man fått mer kunskapPerfluorinated compounds (PFCs), phthalates, manganese and selenium are ubiquitous in the environment and humans and influence fetal growth and development. Register and biobank based case-control studies were conducted to investigate the relationship between prenatal exposure to these chemicals and attention deficit hyperactivity disorder (ADHD) in childhood. The study base comprised children bo

Aims. We attempt to derive accurate transition probabilities for astrophysically interesting spectral lines of Nb II and Nb III and determine the niobium abundance in the Sun and metal-poor stars rich in neutron-capture elements. Methods. We used the time-resolved laser-induced fluorescence technique to measure radiative lifetimes in Nb II. Branching fractions were measured from spectra recorded u

Introduction: Biomarkers of brain damage and head injury are potentially useful tools in the management of afflicted patients. Particularly S100B has received much attention and has been adapted into clinical guidelines. Alcohol intoxication and higher age (65 years and over) have been used as risk factors for serious complications following head injury. The effect of these factors on S100B levels

Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (