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Although interactions in biological systems occur in the presence of a large number of charged species, the binding of charged ligands to different biomolecules is often analyzed in a simplified model focusing only upon the receptor, ligand, and added salt. Here we demonstrate that the presence of charged macromolecules can affect binding to the receptor in an unexpected way. Experimental studies

We compare different procedures for combining fixed-order tree-level matrix element generators with parton showers. We use the case of W-production at the Tevatron and the LHC to compare different implementations of the so-called CKKW scheme and one based on the so-called MLM scheme using different matrix element generators and different parton cascades. We find that although similar results are o

Sveriges ordförandeskap i EU 2001

Genomic DNA from each of four Acl individuals (genotypes AO1, AO1var, AO2) and one AclB individual was used as a template for amplifying exons 6 and 7 of the ABO genes, which were subsequently sequenced. In all the Ael alleles a single nucleotide insertion, compared to the A consensus sequence, was observed that would alter the amino acid sequence of the glycosyltransferase immediately after its p

Patch-clamp recordings and glucagon release measurements were combined to determine the role of plasma membrane ATP-sensitive K+ channels (K-ATP channels) in the control of glucagon secretion from mouse pancreatic alpha-cells. In wild-type mouse islets, glucose produced a concentration-dependent (half-maximal inhibitory concentration [IC50] = 2.5 mmol/l) reduction of glucagon release. Maximum inhi

This thesis concerns economic aspects of ageing and investigates incentives and outcomes related to this process. The thesis is a collection of five essays. An introductory chapter provides an overall economic perspective of ageing. Essay 1 (ch 2) examines mortality risks via duration analysis of widowed individuals in Scania, Sweden during the 19th century. The findings are qualitatively in line

Popular Abstract in Swedish Inom många olika fält hyllas dialogen. Det finns en stark och utbredd tro, främst i det västerländska samhället, att lyckas man bara upprätta en dialog kan man planera i samförstånd och lösa problem. Människor talar med varandra för att förstå, hjälpa varandra och för att skapa gemensamma värden och målsättningar. I studiet av samtal upptäcker man emellertid snabbt att In the spring of 1997 a group of parents of deaf and hearing-impaired children and representatives of a special school in the south of Sweden began to hold formally arranged meetings in order to start a “dialogue”. This particular form of collaboration became the focus of this study. The meetings lasted two to three hours and I attended seventeen of them. The transcriptions of those meetings form

On contemporary rock'n roll movies as pastische.

According to the so-called Substituted Judgment Standard, a surrogate decision maker, acting on behalf of an incompetent patient, ought to make that health care decision which the patient would have made, had the latter been competent. The most common way of justifying the Substituted Judgment Standard is to maintain that this standard extends patients’ opportunities for self-determination to situ

Why, how, and with what consequences do national governments delegate political authority to supranational institutions? Contrary to the static conceptions of delegation that dominate the existing literature, this article adopts a dynamic approach, where the stages of the delegation process are integrated into a coherent rational institutionalist framework. With demonstrations from the case of the

ATP is released as a cotransmitter together with catecholamines from sympathetic nerves. In the heart ATP has been shown to cause a pronounced positive inotropic effect and may also act in synergy with β-adrenergic agonists to augment cardiomyocyte contractility. The aim of the present study was to investigate the inotropic effects mediated by purinergic P2 receptors using isolated mouse cardiomyo

We have previously described a new and simple method for nerve repair in which continuous longitudinal polyglactin sutures alone are used to bridge limited nerve defects in rats. Here we examined whether such sutures could be used to deliver a growth-promoting substance, triiodothyronine (T3), and enhance regeneration of the rat sciatic nerve. Sutures were pretreated in highly concentrated solutio