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Two families with retinitis pigmentosa showed inheritance of an Arg-16-His ROM1 gene mutation with either an Arg-13-Trp RDS mutation or an Arg-135-Trp RHO mutation. The phenotypes of double and single heterozygotes were determined to examine the hypothesis that digenic inheritance may increase disease expression. In the family with ROM1 and RDS mutations, single heterozygotes were normal but one d

The calcination kinetics of limestone was investigated by TGA at 600-1000-degrees-C and from 1 mbar to 1 atm. The temperature, total pressure, CO2 partial pressure and particle size affect the calcination rate. Above 90% of calcination efficiency can be reached in less than 2.5 s at 1000-degrees-C and 1 mbar. Under the conditions of eliminating all diffusion resistances, the instantaneous rate of

Acute otitis media (AOM) is the most common reason for outpatient antimicrobial therapy. Mixed infections pose a potential problem, since the first-line drug used for the treatment of AOM, amoxicillin, can be neutralized by ß-lactamase-producing pathogens of the upper respiratory tract. To study the effects of a 5-day course of amoxicillin on a mixed middle ear infection, rats were challenged with

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Purpose The diagnostic value and cost-efficiency of MR imaging were compared with US before endoscopic retrograde cholangiopancreatography (ERCP) in patients with clinically suspected biliary tract disease. Material and Methods: In a prospective study of 219 patients, 85 were examined with both MR and US before ERCP. Results: To find the correct diagnosis in the jaundiced patients the sensitivity

We counted butterflies in almost all open grasslands in an area of 8000 hectare over five years (2001-2005) in the central part of the parish of Stenbrohult, southern Sweden (Fig. 1; 56 degrees 37' N, 14 degrees 11' O). This area is currently dominated by forests. Grasslands, mainly grazed by cattle and horses, only cover about 6 % of the area. The study area consisted of 18 farms, most ot them ar

Solvent induced optimization of energy transfer properties in a series of Zn(II)-porphyrin-appended dendrimers has been studied by means of exciton-exciton annihilation. Upon changing from a polar solvent (tetrahydrofuran) to a non-polar solvent (3-methyl-pentane), the annihilation energy transfer rates increase by 28-44%. This is related to a decrease of the hydrodynamic radius, which enhances th

Violaxanthin deepoxidase (VDE) has been purified from spinach (Spinacia oleracea) leaves. The purification included differential sonication of thylakoid membranes, differential (NH4)2SO4 fractionation, gel filtration chromatography and finally either hydrophobic interaction chromatography or anion exchange chromatography. A total purification of more than 5000-fold compared to the original thylako

Much attention is now being paid to health and nutrition claims for foods. There are already many food products on the market with claims appealing to consumers about health effects beyond provision of basic nutrients. One important basis for claims is the increasingly documented effect of dietary components on body functions. There are three main reasons for assessing the scientific substantiatio

Objective. To evaluate the longitudinal development of the tricuspid gradient (TG) for screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). Methods. Doppler echocardiography was performed 506 times in order to estimate TG in 227 consecutive patients with SSc. The value of biochemical markers for predicting TG levels and development was assessed through analyses of pro-b

Grossman and Zhou [1993. Optimal investment strategies for controlling drawdowns. Math. Finance 3, 241-276] proposed a strategy to maximize the asymptotic long-run growth rate of one's fortune F, subject to its never falling below lambda sup(0 <= t'<= t) F(t')e(r(t-t')), where 0 <=lambda <= 1 is a fixed constant chosen by the investor and r is a fixed, known, non-negative, continuously compounded

A robot has to visit all nodes and traverse all edges of an unknown undirected connected graph, using as few edge traversals as possible. The quality of an exploration algorithm A is measured by comparing its cost (number of edge traversals) to that of the optimal algorithm having full knowledge of the graph. The ratio between these costs, maximized over all starting nodes in the graph and over al

The Einstein equations (EE) are certain conditions on the Riemann tensor on the real Minkowski space M. In the twistor picture, after complexification and compactification M becomes the Grassmannian Gr(2)(4) of 2-dimensional subspaces in the 4-dimensional complex one. Here we answer for which of the classical domains considered as manifolds with G-structure it is possible to impose conditions simi

Members of the membrane-associated proteins in the eicosanoid and glutathione metabolism (MAPEG) superfamily have been subjected to two-dimensional crystallization experiments. A common denominator for successful attempts has been the use of a low lipid/protein ratio in the range of 1-9 (mol/mol). Electron crystallography demonstrated either hexagonal or orthorhombic packing of trimeric protein un

Indium Tin Oxide (ITO) thin films with a variety of microstructures were deposited using a large area conventional DC magnetron sputtering system for flat panel displays manufacturing. Highly uniform ITO films with an average thickness of ∼100 ± 3 nm on the ∼0.6 m2 substrate area were obtained. Film structures with small amounts of crystalline sites were produced by room temperature deposition, an