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A conventional level-shifter is modified to extend the operation range down to subthreshold regime. Leakage current is reduced by utilizing transistor stacking, channel stretching, and reverse body biasing. The design has a standard-cell compliant layout and is fully integrated in a conventional digital design flow. The level-shifter is manufactured in 65 nm CMOS, and functionality is verified by
Because of their synthetic accessibility, molecularly imprinted polymer (MIP) nanoparticles are ideal building blocks for preparing multifunctional composites. In this work, we developed a general photocoupling chemistry to enable simple conjugation of MIP nanoparticles with inorganic magnetic nanoparticles. We first synthesized MIP nanoparticles using propranolol as a model template and perfluoro
The implementation of new surgical techniques offers chances but carries risks. Usually, several years pass before a critical appraisal and a balanced opinion of a new treatment method are available and rely on the evidence from the literature and expert's opinion. The frozen elephant trunk (FET) technique has been increasingly used to treat complex pathologies of the aortic arch and the descendin
Disperse dyes are well-known contact sensitizers not included in the majority of commercially available baseline series.
Flat-histogram techniques provide a powerful approach to the simulation of first-order-like phase transitions and are potentially very useful for protein studies. Here, we test this approach by implicit solvent all-atom Monte Carlo (MC) simulations of peptide aggregation, for a 7-residue fragment (GIIFNEQ) of the Cu/Zn superoxide dismutase 1 protein (SOD1). In simulations with 8 chains, we observe
Temperature measurements in trunks and branches in a mature ca. 100 years-old mixed pine and spruce forest in central Sweden were used to estimate the heat storage in the tree biomass. The estimated heat flux in the sample trees and data on biomass distributions were used to scale up to stand level biomass heat fluxes. The rate of change of sensible and latent heat storage in the air layer below t
Measuring the diffusivity of various substances in cortical bone is in general difficult. For instance, making use of micro computed tomography requires agents that can be separated from bone, blood and other substances that exist in cortical bone. Here a more easily accessible method is presented. A series of cortical bovine bone samples were put in a saturated solution of potassium chloride for
Right-wingauthoritarianism (RWA) is regularly implicated as a potential risk factor of abusive behavior, whereas social dominance orientation (SDO) is not. We compared RWA and the two subscales of SDO, SDO-Dominance and SDO-Egalitarianism, as factors behind legitimization and hypothetical self-involvement in the use of torture-like abusive behavior (a scenario from Abu-Ghraib military prison). Int
Purpose The implementation and control processes of project planning and scheduling involve a wide range of methods and tools. Despite the development and modification and integration of the project management theory with newer scheduling approaches in particular, practitioners’ views on the efficiency and effectiveness of these methods and tools differ. This situation can be attributed in part to
NERICA, a new group of high-yielding and stress-tolerant upland rice varieties developed by the Africa Rice Center, is changing production strategies of many Ugandan households. This article contributes a better understanding of processes leading to NERICA-related household outcomes in Hoima District, Uganda, by examining patterns of intrahousehold production relations and their consequences for h
We introduce a new algebraic sieving technique to detect constrained multilinear monomials in multivariate polynomial generating functions given by an evaluation oracle. The polynomials are assumed to have coefficients from a field of characteristic two. As applications of the technique, we show an O^∗(2^k)-time polynomial space algorithm for the k-sized Graph Motif problem. We also introduce a ne
A procedure for acceleration feedback control of the delayed nonlinear teleoperation system is proposed. The acceleration feedback is applied to the master controller, while in the slave side the position error plus nonlinear damping controller is used to guarantee the input-to-state stability (ISS) of the controlled system. The Lyapunov-Krasovskii methodology is applied to analyse the ISS of the
The ForSAFE-VEG model was used to estimate atmospheric nitrogen deposition and climate effects on soil chemistry and ground vegetation in alpine and subalpine zones of the northern and central Rocky Mountains region in the USA from 1750 to 2500. Model simulations for a generalized site illustrated how the critical load of atmospheric nitrogen deposition could be estimated to protect plant biodiver
Inhibition of dipeptidyl peptidase-4 (DPP-4) is an established glucose-lowering strategy for the management of type 2 diabetes mellitus. DPP-4 inhibitors reduce both fasting and postprandial plasma glucose levels, resulting in reduced HbA1c with low risk for hypoglycaemia and weight gain. They act primarily by preventing inactivation of the incretin hormones glucose-dependent insulinotropic polype
Infections are a major cause of morbidity and mortality in patients with multiple myeloma. To estimate the risk of bacterial and viral infections in multiple myeloma patients, we used population-based data from Sweden to identify all multiple myeloma patients (n=9 253) diagnosed from 1988 to 2004 with follow-up to 2007 and 34 931 matched controls. Cox proportional hazard models were used to estima
Aims: To evaluate the effects of adding glucagon-like peptide-1 (GLP-1) analogue therapy to insulin on glycated hemoglobin (HbA1c), weight, insulin dosage, treatment satisfaction, and risk of hypoglycaemia. Methods: Type 2 diabetes patients with insulin therapy receiving a GLP-1 analogue at 4 Swedish centers were studied. Hypoglycemia was evaluated using glucometers and patient self-report. The Di
Abstract in UndeterminedThis article aims to provide a historical perspective to the emergence of trust-based control systems in the workplace. These systems are often seen as a response to increasedflexibility requirements following the progress of digital technology, globalisationand an increased knowledge content in production. In contrary to this opinion, itis argued in the article that the ph
Bladder exstrophy, a severe congenital urological malformation when a child is born with an open urinary bladder, is the most common form of bladder exstrophy-epispadias complex (BEEC) with an incidence of 1:30.000 children of Caucasian descent. Recent studies suggest that WNT genes may contribute to the etiology of bladder exstrophy. Here, we evaluated WNT pathway genes in 20 bladder exstrophy pa
