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Optimal sampling design with nonparametric population modeling offers the opportunity to determine pharma-cokinetic parameters for patients in whom blood sampling is restricted. This approach was compared to a standard individualized modeling method for meropenem pharmacokinetics in febrile neutropenic patients. The population modeling program, nonparametric approach of expectation maximization (N
: presented at the 2003 annual meeting of the Royal Swedish Academy of Engineering Sciences
A new method for noise reduction using spatiotemporal smoothing is presented in this paper. The method is developed especially for reducing the noise that arises when acquiring video sequences with a camera under very dim light conditions. The work is inspired by research on the vision of nocturnal animals and the adaptive spatial and temporal summation that is prevalent in the visual systems of t
A new mesoporous silica structure with cubic Iad symmetry has been synthesized. The structure has very large unit cell dimensions, up to 250 Å in the as-synthesized form and 222 Å after calcination, and the surface area is around 700 m2/g. The syntheses were done according to well-established synthesis conditions with the triblock copolymers Pluronics P103 or P123, except for the addition of NaI t
The basic features of a simple radial position-sensitive detector design, construction and performance, are described in detail in this paper. The electronics and method used to correlate the position information from the spectrum recorded by the detector are presented. Monte Carlo simulations of the performance of the detector embedded in a time of flight analyser show that such an instrument ena
An iterative decoding scheme for woven convolutional codes is presented. It operates in a window sliding over the received sequence. This exploits the nature of convolutional codewords as infinite sequences and reflects the concept of considering convolutional encoding and decoding as a continuous process. The decoder is analyzed in terms of decoding delay and decoding complexity. Its basic buildi
Software applications are of great importance in organisations, and performance of an organisation depends on how hosting of software applications are organised. This thesis deals with the question: Why and how organisations decide on specific sourcing options for software applications hosting. The thesis describes and explains sourcing decision-making processes made in the Swedish Post (MeLo) and
A combined quantum chemical statistical mechanical method has been used to study the solvation of urea in water, with emphasis on the structure of urea. The model system consists of three parts: a Hartree-Fock quantum chemical core, 99 water molecules described with a polarizable force-field, and a dielectric continuum. A free-energy profile along the transition of urea from planar to a nonplanar
Popular Abstract in Swedish Inflammation är vävnadens svar på yttre störning och syftar till att eliminera främmade ämnen såsom bakterier men under vissa omständigheter initieras den inflammatoriska reaktionen av ofarliga substanser eller för starkt mot patogener och kan därmed orsaka vävnadsskada och är en underliggande mekanism vid många vanliga sjukdomar inkluderande allergier, blodförgiftning Leukocyte recruitment is considered to playa key role in numerous inflammatory diseases. Tissue accumulation of Jeukocytes is a multi-steps process comprising rolling, adhesion and transmigration. This process depends on the function of several different cells, including leukocytes, endothelial cells, mast cells and macrophages as well as a wide spectrum of inflammatory mediators, such as TNF-alph
The effects of UV-C (254 nm) and UV-B (280-320 nm) on chlorophyll fluorescence induction and ultraweak luminescence (UL) in detached leaves of Hibiscus rosa-sinensis L. were investigated. UL from leaves exposed to UV-B and UV-C radiation reached a maximum 72 h after irradiation. In both cases most of the light was of a wavelength over 600 nm. An increase in the percentage of long wavelength light
The focus of this thesis was to explore the interaction between IgD and Moraxella catarrhalis and Haemophilus influenzae. These two respiratory pathogens are responsible for otitis media in children, and exacerbations in patients afflicted with predisposing conditions such as chronic obstructive pulmonary disease (COPD). Both M. catarrhalis and H. influenzae have been shown to bind IgD in a non-im
Popular Abstract in Swedish Hypens grammatik informationsteknologi i återberättandet som myt, praktiserad verklighet och vetenskaplig analys alternativt IT-hypen åren innan och omkring millennieskiftet i väntan på nästa hype och nästa och nästa ... Detta är titeln på min avhandling, som snarare fokuserar på en speciell ”hype” än att den tar upp informationssamhället som sådant. I detta fall, hypeThe Grammar of The Hype digital information technology -IT- in retelling as myth its experienced reality and in scientific analysis or the IT-hype in the years prior to and at the turn of the millennium waiting for the next hype and the next, and“next”... This is the title of my thesis and it focuses rather on a particular “hype” than deals with the so-called information society as such. What is
A molecularly imprinted polymer (MIP) was prepared using metsulfuron-methyl (MSM) as the template molecule. A combinatorial protocol has been employed to optimize the polymer in terms of the kind and relative amounts of functional and cross-linking monomers. A copolymer of 2-(trifluoromethyl)acrylic acid (TFMAA) and divinylbenzene (DVB) showed the highest binding capacity for MSM. The binding char
The effects of crossbreed and of RN phenotype on pork and its eating quality were evaluated in four different pig crossbreeds [involving Swedish Landrace (L) × Yorkshire (Y) sows and Hampshire (H), Duroc (D), Yorkshire (Y) or Hampshire × Yorkshire (HY) as the terminal sire]. Pigs from the LYH crossbreed were also classified as either carriers or non-carriers of the RN− allele. In the crossbreeds i
Lipid-filled macrophages (foam cells) are a defining feature of atherosclerotic plaques. Foam cells contain lipid dro plet- associated proteins that in other cell types regulate lipid turnover. In foam cell such proteins may directly affect lipid droplet formation and lipid efflux. Differentiated primary human monocytes or THP-1 cells were lipid loaded by incubation with aggregated low density lip
Popular Abstract in Swedish Universitet och högskolor har i kölvattnet av ett framväxande kunskapssamhället hamnat under kraftig institutionell press från en förändrad nationell forskningspolitik, de forskningsfinansierande aktörernas förändrade strategier och en snabb och omvälvande vetenskaplig dynamik. Avhandlingen handlar om hur Lunds universitet har reagerat på och hanterat dessa förändringspIn the wake of an emerging knowledge society, universities around the world have come under severe institutional pressure from changing national research policies, financing organizations´ new strategies and turbulent research dynamics. This study examines how Lund University in Sweden manages these institutional pressures. The study explores how the university leadership ? rector and the governin
Today, cognitive impairment can be successfully treated with acetylcholine esterase inhibitors (AChE-I) in many, but not all, patients with Alzheimer's disease (AD). To investigate the relation between tacrine treatment, inheritance of ApoE epsilon4 alleles, and rate of progression, the differences in MMSE and CIBIC scores (efficacy parameters) after 6 and 12 months of tacrine (an AChE-I) treatmen
Deep brain stimulation is an accepted technique for the treatment of Parkinson's disease. Deep brain stimulation affects the electrical functions of neurons and several explanations are available to describe this treatment modality. Such as depolarization blockade, synaptic inhibition, synaptic depression and stimulation induced modulation of pathological network activity. An electrical impedance
