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Vanadate and peroxovanadate (pV), potent inhibitors of tyrosine phosphatases, mimic several of the metabolic actions of insulin. Here we compare the mechanisms for the anti-lipolytic action of insulin, vanadate and pV in rat adipocytes. Vanadate (5 mM) and pV (0.01 mM) inhibited lipolysis induced by 0.01-1 microM isoprenaline, vanadate being more and pV less efficient than insulin (1 nM). A loss o
Popular Abstract in Swedish Sammanfattning I debatter och forskning om narkotikapolitik anges den svenska och nederländska modellen ofta som ett motsatspar. Såväl målet för, som utformningen av, narkotikapolitiken har framställts som radikalt olika. Detta synsätt kan sägas vara riktigt. Målet för den svenska narkotikapolitiken är att skapa ett narkotikafritt samhälle. Den nederländska strävar efteIn debates about the Swedish and Dutch drug policies are usually positioned as opposites. The goal for the Swedish drug policy is to create a 'drug-free society'; while in the Netherlands a harm reduction approach prevails. In this study a drug policy is considered a practice of formal social control that can develop differently depending on the contexts in which it emerged. The period studied sta
In this paper, we propose an adaptive observer for dynamically positioned ships, that can be used together with the controller shown by Fossen and Grovlen, to design an observer-based adaptive control scheme. The resulting closed-loop system is globally asymptotically stable with respect to the ship positions and velocities, and globally stable with respect to adaptation to unknown parameters. A d
Popular Abstract in Swedish Avhandlingen är en ny edition med en parallell engelsk översättning av åtta grekiska berättelser relaterade till ökenfadern Daniel från Sketis: 1) Abba Daniel från Sketis; 2) Abba Marcus, den helige dåren; 3) Den blinde mannen; 4AB) En helig och kysk ung kvinna; 5) Kvinnan som låtsades vara en drinkerska; 6) Eulogios Stenhuggaren; 7) Andronikos Penningväxlaren och hans This volume is a new edition with a parallel English translation of eight Greek stories related to Daniel of Sketis: 1) Abba Daniel from Sketis; 2) Abba Mark the Fool; 3) The blind man; 4AB) A holy and chaste young woman; 5) The woman who pretended to be a drunkard; 6) Eulogios the Stone-cutter; 7) Andronikos the Money-dealer and his wife Athanasia; 8) Anastasia Patrikia. The stories deal with se
Using simple sequence-based potentials, the folding properties of a designed three-helix-bundle protein, an alpha-helix and a beta-hairpin are studied. The three-helix-bundle protein is modelled using 5-6 atoms per amino acid and is found to undergo a first-order-like folding transition in which chain collapse and helix formation cannot be separated, which is in-accord with experimental data. The
In this article, we discuss and contradict a recent publication by Russo et al., which suggests that the filtration of large amounts of albumin followed by transtubular transport of intact albumin is a physiological phenomenon.
The interventions of portable digital devices such as mobile telephones, mp3 players, PDAs and many others, have contributed to the formation of contemporary notions of space. The impact of these devices' mobility (informing the users' mobility) could even be paralleled to the shift from the effects of still photography to those of film in the 19th century. Especially important for the perspective
Recent experiments indicate that the external perturbations, related e.g. to high-amplitude shear oscillations of the surface of a quartz crystal microbalance sensor, may suppress binding of mesoscopic aggregates (e.g., polystyrene spheres, vesicles, large proteins, etc.) to the surface. Using a simple kinetic model, we derive equations making it possible to conceptually understand and to mathemat
A 5-year follow-up study of 476 type I adult diabetic patients previously studied cross sectionally revealed that, during the observation period, 19 patients died and 30 developed cardiovascular or renal disease, such as myocardial infarction (n = 8), cerebrovascular disease (n = 3), amputation (n = 6), and renal insufficiency (n = 13). The patients were registered by one and the most-severe event
Comparative genomic hybridization analysis has demonstrated that breast tumors from BRCA1 and BRCA2 germ-line mutation carriers contain a large number of chromosomal copy number gains and losses. A high regional copy number gain at 6q22-q24 was observed in one BRCA1 tumor, and fluorescence in situ hybridization analysis indicated a strong amplification of the MYB oncogene (15 copies of MYB compare
Mass balance pharmacokinetics, with simultaneous blood sampling from an artery and the internal jugular vein, was used to characterize the cerebral uptake of ketamine, norketamine, and midazolam in normoventilated pigs. Intravenous injections of ketamine or midazolam decreased the cerebral blood flow (CBF) by one third, as measured by intermittent 133Xe washout. By means of pharmacodynamic models,
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The ability of protein kinase C and casein kinase 2 substrate in neurons (PACSIN)/syndapin proteins to self-polymerize is crucial for the simultaneous interactions with more than one Src homology 3 domain-binding partner or with lipid membranes. The assembly of this network has profound effects on the neural Wiskott-Aldrich syndrome protein-mediated attachment of the actin polymerization machinery
"You can prove anything with statistics" is a well-known expression, and this might be true if the methods are not properly used and/or the results are not reviewed critically. This demands knowledge about statistical methodology and practice in critically analysis. However, it is not only the researcher that needs this kind of knowledge but also professionals in clinical practice who will be info
