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European Hernia Society guidelines on prevention and treatment of parastomal hernias

Background: International guidelines on the prevention and treatment of parastomal hernias are lacking. The European Hernia Society therefore implemented a Clinical Practice Guideline development project. Methods: The guidelines development group consisted of general, hernia and colorectal surgeons, a biostatistician and a biologist, from 14 European countries. These guidelines conformed to the AG

Accumulation effects in modulation spectroscopy with high-repetition-rate pulses : Recursive solution of optical Bloch equations

Application of the phase-modulated pulsed light for advance spectroscopic measurements is the area of growing interest. The phase modulation of the light causes modulation of the signal. Separation of the spectral components of the modulations allows to distinguish the contributions of various interaction pathways. The lasers with high repetition rate used in such experiments can lead to appearanc

Concentrating small particles in protoplanetary disks through the streaming instability

Laboratory experiments indicate that direct growth of silicate grains via mutual collisions can only produce particles up to roughly millimeters in size. On the other hand, recent simulations of the streaming instability have shown that mm/cm-sized particles require an excessively high metallicity for dense filaments to emerge. Using a numerical algorithm for stiff mutual drag force, we perform si

Circular Business Models in the Mobile Phone Industry

The circular economy offer opportunities to reduce resource use and waste whilst providing business opportunities. This is also true in the mobile phone industry that has been characterised by high rates of product obsolescence. The emergence of the smart phone has changed the landscape, making repair, refurbishment and resell attractive to businesses and consumers. Moreover, emerging modular phon

Trycksättning av trapphus

Trycksättning har blivit en vanlig metod för att begränsa spridningen av brandgaser till trapphus som används för utrymning i höga byggnader. De trapphus som är aktuella för metoden är så kallade trapphus Tr1 som används i vissa byggnader över 8 våningar. Trapphuset ska vara utformat med en sluss mellan trapphus och verksamheten och traditionellt har denna sluss varit öppen mot det fria för att un

From Agricultural Benefits to Aviation Safety : Realizing the Potential of Continent-Wide Radar Networks

Migratory animals provide a multitude of services and disservices-with benefits or costs in the order of billions of dollars annually. Monitoring, quantifying, and forecasting migrations across continents could assist diverse stakeholders in utilizing migrant services, reducing disservices, or mitigating human-wildlife conflicts. Radars are powerful tools for such monitoring as they can assess dir

Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm

Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming, and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-depth transcriptome analysis of this mESC state reveals Dppa3 as a direct downstream target of Tbx3.

Red blood cells promote survival and cell cycle progression of human peripheral blood T cells independently of CD58/LFA-3 and heme compounds

Red blood cells (RBC) are known to modulate T cell proliferation and function possibly through downregulation of oxidative stress. By examining parameters of activation, division, and cell death in vitro, we show evidence that the increase in survival afforded by RBC is due to the maintenance of the proliferative capacity of the activated T cells. We also show that the CD3+CD8+ T cell subset was p

Monitoring progression of clinical reasoning skills during health sciences education using the case method - A qualitative observational study

Background: Outcome- or competency-based education is well established in medical and health sciences education. Curricula are based on courses where students develop their competences and assessment is also usually course-based. Clinical reasoning is an important competence, and the aim of this study was to monitor and describe students' progression in professional clinical reasoning skills durin

Decrease in bone mineral density during three months after diagnosis of early rheumatoid arthritis measured by digital X-ray radiogrammetry predicts radiographic joint damage after one year

Background: Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a computerized technique to estimate bone mineral density (BMD) from hand radiographs. The aim of this study was to evaluate whether decrease in BMD of the hands (BMD loss), as determi

Genetic anticipation in Swedish Lynch syndrome families

Among hereditary colorectal cancer predisposing syndromes, Lynch syndrome (LS) caused by mutations in DNA mismatch repair genes MLH1, MSH2, MSH6 or PMS2 is the most common. Patients with LS have an increased risk of early onset colon and endometrial cancer, but also other tumors that generally have an earlier onset compared to the general population. However, age at first primary cancer varies wit

Don't Push This Button : Phoenician Sarcophagi, Atomic Priesthoods and Nuclear Waste

The article discusses the impact of historical sciences, classical philology and religious studies on the field of “Nuclear Semiotics”, the scholarly discussion concerning communicating information about nuclear waste disposal into the far future. The author uses examples such as a Phoenician funerary inscription, the Antikythera Mechanism, ancient water power, and the reconstruction of mythology

Koppling mellan SSRI och våld

Referat om en studie som tittat på kopplingen mellan SSRI-preparat och våld.A summary of a study showing that there may be a connection between the use of SSRI-medication and violence.

Physical interpretation of the "kinetic energy release" effect in the double photoionization of H2

A physical interpretation is given for the variation with internuclear separation of the fully differential cross section for double photoionization of H2. This effect is analyzed in a geometry where the fourbody interaction is completely probed. Excellent agreement is found between experiment and time-dependent close-coupling theory after convoluting the latter over the relevant solid angles. We