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Molecular classification of breast cancer (BC) identified diverse subgroups that encompass distinct biological behavior and clinical implications, in particular in relation to prognosis, spread, and incidence of recurrence. Basal-like breast cancers (BLBC) compose up to 15% of BC and are characterized by lack of estrogen receptor (ER), progesterone receptor (PR), and HER-2 amplification with expre
The Mar del Plata International Water Conference provided the first global assessment of the water sector. It was found that in most developing countries the state of water supply and sanitation services were deplorable. Consequently, a call for concerted action to improve coverage and efficiency of the water supply and sanitation sector was launched. This call resulted in the International Water
Objectives To investigate the capacity of Cerament (R), an injectable bone substitute, to guide bone generation from a cortical surface. Materials and method Cerament (R) was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats. Results In both groups, the thickness of the bone corte
Recently, we constructed a focused antibody library tailored to interact with haptens. High functionality of this library was demonstrated, as specific binders could be retrieved to a range of different haptens. In the current study we have developed a mutagenesis and selection strategy in order to further fine-tune the hapten binding properties of these antibody fragments. Testosterone was chosen
This paper is a translation of my "Preference Utilitarianism by Way of Preference Change?", in which I revisit Richard Hare’s classical and much discussed argument for preference utilitarianism (Moral Thinking, 1981), which relies on the conception of moral deliberation as a process of thought experimentation, with concomitant preference change. The paper focuses on an apparent gap in Hare’s reaso
The subject of the thesis is the psychê, a Greek word whose closest equivalent is the Swedish “själ”, the English “soul”, the French “âme” and the German “Seele”. The meanings of these words are far from being the same. What is more, the Greek psychê has shifting meanings, both synchronically and diachronically speaking. We are faced with two problems: What does the word psychê designate and how i
Background: Hitherto, risk prediction models for preoperative ultrasound-based diagnosis of ovarian tumors were dichotomous (benign versus malignant). We develop and validate polytomous models (models that predict more than two events) to diagnose ovarian tumors as benign, borderline, primary invasive or metastatic invasive. The main focus is on how different types of models perform and compare. M
Obesity and associated metabolic disorders have been implicated in liver carcinogenesis; however, there are little data on the role of obesity-related biomarkers on liver cancer risk. We studied prospectively the association of inflammatory and metabolic biomarkers with risks of hepatocellular carcinoma (HCC), intrahepatic bile duct (IBD), and gallbladder and biliary tract cancers outside of the l
Collagen-induced arthritis (CIA) is a well studied mouse model of the human disease rheumatoid arthritis (RA). Both CIA and RA are complex diseases affected by multiple genes as well as environmental factors. Identifying the genes that determine susceptibility to arthritis would give invaluable clues to the largely unknown aetiology of RA. In this study, we dissected a known locus, Cia6, as well a
Context: The questions of how many individuals and how much time to use for a single testing task are critical in software verification and validation. In software review and usability evaluation contexts, positive effects of using multiple individuals for a task have been found, but software testing has not been studied from this viewpoint. Objective: We study how adding individuals and imposing
Using conceptual dimensions identified by the literature on political leadership, this article compares its transformations at the local level in Europe. Often associated with the alleged shift to governance, the strengthening of the executive comes forward as the underlying tendency in contemporary local leadership. Empowered individualised leadership emerges, in terms of coming to and taking off
We present results of a search for two hypothetical strange dibaryon states, i.e. the H-dibaryon and the possible (Lambda n) over bar bound state. The search is performed with the ALICE detector in central (0-10%) Pb-Pb collisions at root S-NN = 2.76 TeV, by invariant mass analysis in the decay modes (Lambda n) over bar (d) over bar pi(+) and H-dibaryon -> Lambda p pi(-). No evidence for these bou
