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Mucosa-associated lymphoid tissue lymphoma-translocation protein 1 (MALT1) is an attractive target for the development of modulatory compounds in the treatment of lymphoma and other cancers. While the three-dimensional structure of MALT1 has been previously determined through X-ray analysis, its dynamic behaviour in solution has remained unexplored. We present here dynamic analyses of the apo MALT
Within the European FEL Design Study a seeded HGHG-FEL test bench will be set up at MAX-lab. In the modulator the 3rd harmonic of a Ti:Sapphire laser (267nm) interacts with the electron beam. In the following dispersive section the energy modulation is converted into a spatial modulation. The radiator emits at the third harmonic (89nm). The electron beam height at MAX-lab of 400mm requires a speci
The MAX-II storage ring is a third generation synchrotron light source recently commissioned in Lund, Sweden. A description of the ring is presented along with an evaluation of the performance during commissioning. The status and most recent results of the early stages of operation are also presented.
Thomas Mathiesen’s theories, his activism and his scholarship are needed, important and useful for contemporary researchers concerned with social change and social justice. At this moment in time, when strong social movements and abolitionism are back on the agenda, Mathiesen’s theories can not only be revitalised, but moved forward in the everlasting unfinished fashion. Mathiesen’s work might be
The differentiation of human pluripotent stem cells into ventral mesencephalic dopaminergic (DA) fate is relevant for the treatment of Parkinson's disease. Shortcuts to obtaining DA cells through direct reprogramming often include forced expression of the transcription factor LMX1A. Although reprogramming with LMX1A can generate tyrosine hydroxylase (TH)-positive cells, their regional identity rem
My written contribution responds to the questions: How des your practice relate to placemaking? How is it possible to use sense of place as material and starting point for research or artistic work? What methods do you use for co-creation and relationship building in relation to place?
Objectives: Variation exists in the capabilities of electronic healthcare records (EHRs) systems and the frequency of their use by primary care physicians (PCPs) from different settings. We aimed to examine the factors associated with everyday EHRs use by PCPs, characterise the EHRs features available to PCPs, and to identify the impact of practice settings on feature availability. Study design: C
Incompleteness, that is, a feeling that things are “not just right”, is an understudied symptom of obsessive-compulsive disorder (OCD). We used data from 167 adult individuals with OCD who received internet-delivered cognitive behaviour therapy (ICBT) to examine how incompleteness was associated with clinical characteristics and treatment outcomes. Incompleteness was assessed using the Obsessive-C
This paper presents an experimental study on the joint effects of concurrent airflow and sample width on the steady flame spread behaviors. Flame spread parameters, including flame height, preheating length, heat flux distribution, flame spread rate (FSR) and pyrolysis length, were measured and analyzed comprehensively. Results show that the FSR and pyrolysis length increase with sample width and
BACKGROUND: While experimental data suggest that selective intracoronary hypothermia decreases infarct size, studies in patients with ST-elevation myocardial infarction (STEMI) are lacking. AIMS: We investigated the efficacy of selective intracoronary hypothermia during primary percutaneous coronary intervention (PCI) to decrease infarct size in patients with STEMI. METHODS: In this multicentre ra
Background: There are few large register-based studies on people with intellectual disabilities (ID) that compare outcomes with the general population. Methods: All people in Skåne, the southernmost part of Sweden the 1st of January 2014 was included. Data concerning demographics/vital events, healthcare utilization and service and support for people with ID or autism spectrum disorder (ASD) was c
Background: People with intellectual disabilities (ID) experience barriers to health care, which may have been particularly relevant during the Covid-19 pandemic.Methods: In this register-based study, we identified all people living in Skåne (southernmost region of Sweden) on January 1st, 2014. People with ID (F7) or Down Syndrome (Q90), or service and support for people with ID or autism spectrum
Background: People with intellectual disabilities (ID) often have an extensive and complex disease panorama. However, more knowledge is needed about the disease panorama to gain a deeper understanding of co-morbidity and potential care needs.Methods: Among all people living in Skåne on January 1st, 2014, we established a cohort of 14 716 people with ID (either diagnosis of ID (F7) or Down Syndrome
Background: Women with intellectual disability (ID) may encounter barriers to exercising reproductive agency, self-care during pregnancy, and accessing healthcare to optimize pregnancy outcomes. However, there is to date little evidence to guide policy and practice. We aim to fill this identified knowledge gap by examining pregnancy outcomes among women with ID in comparison with women from the ge
