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Framgångsrik klinisk forskning måste baseras på translationell forskning, där både kliniker och forskare ingår. Sådana team måste utgå från universiteten för att tillgodose kraven på kvalitet. Man bör även diskutera nationella fokusområden för den kliniska forskningen, så att den kompetens som finns i landet tillvaratas.
This thesis reports the work done in the development of a modified Lean Premix Prevaporised (LPP) burner for the use in Alstom Power Sweden’s industrial gas turbines. Incentive for the development of the modified burner have been the need to increase the flame stability over the operating range for the burner, especially for the liquid fuel but also the gaseous fuel operation. Foundation for modif
The effect of adding Thermomyces (formerly Humicola) lanuginosa lipase (TLL) to a monoolein (MO)/sodium oleate (NaO) aqueous cubic liquid crystalline phase has been studied. H-1-NMR, C-13-NMR, H-1-PGSE (Pulsed-magnetic field Gradient Spin-Echo) self-diffusion measurements, and Small Angle X-ray Diffraction were used to follow the degradation of the cubic phase. The reaction sequence in terms of ph
In principle, methods of testing the reliability and safety of constructions are designed with the aim of representing critical conditions for their use. Because of variations within technical systems, including the one for which a certain test was once developed, the validity of the method also varies. The adoption of a standardized test for different applications had to be based on the assumptio
A revised geometric representative model of the lower part of the colon, including the rectum, the urinary bladder and prostate, is proposed for use in the calculation of absorbed dose from injected radiopharmaceuticals. The lower segment of the sigmoid colon as described in the 1987 Oak Ridge National Laboratory mathematical phantoms does not accurately represent the combined urinary bladder/rect
Popular Abstract in Swedish Läkemedelsrelaterade problem hos äldre - Interventioner för att förbättra läkemedelsbehandlingen Läkare inom primärvården står för en stor del av den totala läkemedelsförskrivningen i Sverige och är en viktig målgrupp för läkemedelsindustrins information. Det har i flera uppmärksammade studier från Socialstyrelsen uppmärksammats att läkemedelsbehandlingen för patientIntroduction: Elderly people, in particular those residing in nursing homes, often use many drugs. In general elderly patients are at greater risk of experiencing drug-related problems (DRP), as they have multiple diseases, are using many drugs and have changed physiological status. Objectives: To describe the frequency of potential drug-related problems in the elderly and to evaluate different k
In the optimization of the ring-opening reaction of thiophene-1,1-dioxides, 3-bromo-2,5-dimethylthiophene-1,1-dioxide (1) and 2-(2-hydroxyethyl)piperidine (7) were chosen as model reagents. Solvent, temperature, molar ratio between amine and dioxide and the amount of solvent were variables included in the optimization. A central composite design was chosen for the investigation and a canonical ana
Several different microorganisms have been suggested for coal desulfurization. In the present investigation, the thermophilic archaea Acidianus brierleyi (DSM 1651), Sulfolobus acidocaldarius (DSM 639) and Sulfolobus solfataricus (DSM 1616) were compared with the mesophilic bacterium Thiobacillus ferrooxidans (DSM 583) concerning their capability of removing sulfur from coal. The desulfurization r
Frågan om hur prioriteringar bör göras inom sjukvården har under de senaste decennierna blivit allt mer diskuterad, både internationellt och i Sverige. År 1995 publicerades i Sverige en offentlig utredning med titeln "Vårdens svåra val" som behandlar dessa frågor. I utredningen presenterades följande tre etiska principer som en grund för prioriteringar: människovärdighetsprincipen, behovs- eller s
The application of amperometric biosensor- and chemiluminiscence based methods for rapid detection of viable E. coli in water has been investigated. An amplification of the amperometric signal by a factor of 4 was obtained when the cellobiose dehydrogenase (CDH) biosensor was used instead of a plain graphite electrode for detection of b-galactosidase (b-GAL) activity at 22.5 degrees C. A linear co
Tulasnein (1), a new metabolite with strong antimicrobial and weaker cytotoxic and phytotoxic activity, was isolated from culture filtrates of three strains of the xylariaceous coprophilous fungus Podosordaria tulasnei. The producing strains were identified by their rhizomorphs and by ITS rDNA sequence analysis. A second new metabolite, podospirone (2), was also produced by all three strains where
Reductions of total and LDL-cholesterol and, to a lesser extent, increase in HDL are known to decrease cardiovascular disease (CVD) incidence. All oral estrogens are known to induce such changes in a dose-dependent manner at doses commonly used in ERT, somewhat more markedly for estradiol than for conjugated equine estrogens (CEE). Low-dose estriol used for urogenital discomfort is void of lipid e
