Concrete structures retrofitted with fibre reinforced plastic (FRP) applications have become widespread in the last decade due to the economic benefit from it. This paper presents a finite element analysis which is validated against laboratory tests of eight beams. All beams had the same rectangular cross-section geometry and were loaded under four point bending, but differed in the length of the

This article presents key energy use figures and explores the energy saving potential for electric lighting in office buildings based on a review of relevant literature, with special emphasis on a North European context. The review reveals that theoretical calculations, measurements in full-scale rooms and simulations with validated lighting programs indicate that an energy intensity of around 10

Hos 11,8-9 is characterized by its strong anthropomorphic language and by its (illusory?) disassociation from it. A reference to Israel’s God as “not human” motivates the unexpected change of mind and compassion for God’s Israel. This article is based on a tradition-historical oriented typological reading of the expression “I am God and not human.” It suggests a new interpretation of this expressi

The Lie splitting algorithm is frequently used when splitting stiff ODEs or, more generally, dissipative evolution equations. It is unconditionally stable and is con- sidered to be a robust choice of method in most settings. However, it possesses a rather unfavorable local error structure. This gives rise to order reductions if the evolution equation does not satisfy extra compatibility assumption

BACKGROUND: The aim of the current study was to investigate the possibility of increasing the maximal tolerated dose (MTD) of a tumor-selective radiolabeled antibody when radioimmunotherapy (RIT) is combined with extracorporeal depletion of radioimmunoconjugates from the circulation. Furthermore, the authors evaluated whether this increase in dose improved the therapeutic effect on solid manifest

OBJECTIVE: To define a minimum Standard Set of outcome measures and case-mix factors for monitoring, comparing, and improving healthcare for patients with clinically diagnosed hip or knee osteoarthritis (OA) with a focus on defining the outcomes that matter most to patients. METHODS: An international Working Group (WG) of patients, arthroplasty register experts, orthopedic surgeons, primary care

Norway has built up a remarkable solar photovoltaic (PV) industry over the last 15 years with central industrial players such as the Renewable Energy Corporation Group and Elkem. Norwegian companies are mainly active in manufacturing materials for solar cells, but also other elements of the value chain for solar PVs, such as manufacturing of solar cells, recycling of silicone and of solar cells ha

AIMS: Several cardiovascular disorders (CVDs) are strongly associated with socioeconomic disparities and neighbourhood deprivation. However, no study has determined whether neighbourhood deprivation is associated with atrial fibrillation (AF). We aimed to determine whether there is an association between neighbourhood deprivation and hospitalization for AF.METHODS AND RESULTS: The entire Swedish p

The European Hypothermia Stroke Research Workshop was held in January 2010, in response to the alarming prospects of a significant increase of stroke expected in the coming years globally. Considering that a minority of patients (around 10%) are currently eligible for thrombolytic treatment, there is a need for an efficacious, cost-effective novel therapy that can be implemented broadly within Eur

A pair of tetranuclear iron complexes consisting of two Fe-2(Cl(2)bdt)(CO)(5) subunits (Cl(2)bdt = 3,6-dicholorobenzene-1,2-dithiolate) bridged by different cyclic 1,5-diaza-3,7-diphosphacyclooctane (P2N2) ligands were prepared and structurally characterized. In the solid state, the P2N2 ligands adopt a boat conformation, which results in rather short distances between the two Fe-2(Cl(2)bdt)(CO)(5

Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease was first done more than 20 years ago. Since then, many patients have received transplants, with variable results. During this time, our knowledge of Parkinson's disease has changed and the nature and extent of problems associated with the disorder ha

Understanding the molecular programs of the generation of human dopaminergic neurons (DAn) from their ventral mesencephalic (VM) precursors is of key importance for basic studies, progress in cell therapy, drug screening and pharmacology in the context of Parkinson's disease. The nature of human DAn precursors in vitro is poorly understood, their properties unstable, and their availability highly

Purpose: In addition to genomic signaling, it is accepted that estrogen receptor-alpha (ER alpha) has nonnuclear signaling functions, which correlate with tamoxifen resistance in preclinical models. However, evidence for cytoplasmic ER localization in human breast tumors is less established. We sought to determine the presence and implications of nonnuclear ER in clinical specimens. Experimental D

Background: Patients with ostium secundum atrial septal defects (ASDs) were studied to determine the prevalence of Selvester anteroseptal myocardial infarction QRS points, and to test the hypothesis that there is a relationship between these criteria and thinning and/or scarring of the inter-ventricular septum (IVS). Methods: Demographic, electrocardiographic (ECG), and cardiac magnetic resonance

CONTEXT: High-quality fatigue rating scales are needed to advance the understanding of fatigue and determine the efficacy of interventions. Several fatigue scales are used in Parkinson's disease, but few have been tested using modern psychometric methodology (Rasch analysis). OBJECTIVES: To examine the measurement properties of the generic Functional Assessment of Chronic Illness Therapy-Fatigue (

This study examines the dialogic functions of EXPANSION and CONTRACTION of first-person epistemic and evidential Complement-Taking Predicate (CTP) constructions, such as I think COMPLEMENT, I suppose COMPLEMENT and I know COMPLEMENT, in spoken discourse. It combines corpus and experimental methods (i) to investigate whether CTP constructions are used to open up the dialogic space for new ideas or

P>Adeno-associated virus (AAV)-mediated neuropeptide Y (NPY) overexpression in areas of seizure onset or generalization may be effective for the treatment of pharmacoresistant seizures in focal onset epilepsy. NPY overexpression mediates anticonvulsant activity in various seizures models and antiepileptogenic effects in kindling. Side effects are limited thus suggesting that this therapeutic appro

To resist infections, robust defense mechanisms of the airways are essential. Retinoic acid promotes differentiation and maintains the phenotypic characteristics of bronchial epithelium. In addition, it induces the expression of the antibacterial growth factor midkine (MK). In the present study, we explored the expression and antibacterial activity of MK in an airway context. MK was detected in br