Purpose: Limited data are available about the influence of KIT and PDGFRA mutations on overall survival (OS) of patients with gastrointestinal stromal tumor (GIST) treated with adjuvant imatinib. Patients and Methods: The Scandinavian Sarcoma Group XVIII/AIO multicenter trial accrued 400 patients with a high risk for GIST recurrence after macroscopically complete surgery between February 4, 2004,

Background: Alterations in gastrointestinal (GI) microbial composition have been reported in patients with systemic sclerosis (SSc). However, it is unclear to what degree these alterations and/or dietary changes contribute to the SSc-GI phenotype. Objectives: Our study aimed to 1) evaluate the relationship between GI microbial composition and SSc-GI symptoms, and 2) compare GI symptoms and GI micr

Peritoneal dialysis (PD) uses the peritoneal membrane for dialysis. The peritoneal membrane is a thin layer of tissue that lines the abdomen. The lining is used as a filter to help remove extra fluid and poisonous waste from the blood. Everybody is unique. What is normal for one person’s membrane may be very different from another person’s. The kidney care team wants to provide each person with th

Purpose: To determine whether the APOE-ε4 allele modulates the relationship between regional β-amyloid (Aβ) accumulation and cognitive change in middle-aged cognitively unimpaired (CU) participants. Methods: The 352 CU participants (mean aged 61.1 [4.7] years) included completed two cognitive assessments (average interval 3.34 years), underwent [18F]flutemetamol Aβ positron emission tomography (PE

This paper studies the impact of land use and land cover change (LULCC) on the climate around 2500 years ago (2.5 ka), a period of rapid transitions across the European landscape. One global climate model was used to force two regional climate models (RCMs). The RCMs used two land cover descriptions. The first was from a dynamical vegetation model representing potential land cover, and the second

Background Preterm birth is associated with pulmonary complications early in life; however, long-term risks of asthma into adulthood are unclear. Objective To determine asthma risks from childhood into adulthood associated with gestational age at birth in a large population-based cohort. Methods A national cohort study was conducted of all 4 079 878 singletons born in Sweden during 1973-2013, foll

Ecological and evolutionary processes underlying spatial variation in signals involved in mate recognition and reproductive isolation are crucial to understanding the causes of population divergence and speciation. Here, to test hypotheses concerning the causes of song divergence, we examine how songs of two sister species of Atlantic Forest suboscine birds with innate songs, the Pyriglena fire-ey

Microalgal biomass may have biostimulating effects on plants and seeds due to its phytohormonal content, and harnessing this biostimulating effect could contribute to sustainable agriculture. Two Nordic strains of freshwater microalgae species Chlorella vulgaris and Scenedesmus obliquus were each cultivated in a photobioreactor receiving untreated municipal wastewater. The algal biomass and the su

The optimal selection of characteristic bands and retrieval models for the hyperspectral retrieval of soil heavy metal concentrations poses a significant challenge. Additionally, satellite-based hyperspectral retrieval encounters several issues, including atmospheric effects, limitations in temporal and radiometric resolution, and data acquisition, among others. Given this, the retrieval performan

Kullaberg är Kullabygdens kännemärke, blickfånget där urberget reser sig mot öppen himmel och vidsträckt hav. Vid horisonten möts Öresund och Kattegatt. Detta stenmassiv har en geologi som går mångmiljoner år tillbaka. I skuggan av den väldiga klippformationen breder kulturlandskapet ut sig i all sin variationsrikedom. En jordbruksbygd, inbäddad i skog och äng, som vetter mot den kustnära buskvege

Bakgrund: Centraliseringen av hälso- och sjukvården har medfört ökade avstånd till akutsjukhus, vilket begränsat tillgängligheten till akutsjukvård för personer bosatta på landsbygden. Det medför ett högre krav på ambulanssjukvården att tillgodose befolkningen med god vård inom rimlig tid. Vidare kantas ambulanssjukvården på landsbygden av ytterligare faktorer som kan komma att påverka ambulanssju

Bakgrund: Psykisk ohälsa som leder till självskadebeteende är ett komplext område som ökar i samhället. Det blir allt mer vanligt i unga åldrar. Vårdens bemötande är av betydelse för dessa patienter. Patienter med självskadebeteende är en stor samt ökande patientgrupp även inom ambulanssjukvården. Syfte: Arbetets syfte var att beskriva sjuksköterskors erfarenheter av att vårda patienter med självs

Bakgrund: Ambulanspersonal inom prehospital akutsjukvård ställs ofta inför olika stressfyllda händelser. Olika sorters stressorer förekommer med varierande frekvens och påverkar ambulanspersonal både fysiskt och psykiskt. Stresshantering är en essentiell del i ambulanspersonalens yrke och det finns olika metoder som kan användas för att reducera den arbetsrelaterade stressen som förekommer i yrket

Aims: Iron deficiency (ID) is comorbid in up to 50% patients with heart failure (HF) and exacerbates disease burden. Ferric carboxymaltose (FCM) reduced HF hospitalizations and improved quality of life when used to treat ID at discharge in patients hospitalized for acute HF with left ventricular ejection fraction

We use data from the 17th data release of the Apache Point Observatory Galactic Evolution Experiment (APOGEE 2) to contrast the chemical composition of the recently discovered Gaia Enceladus/Sausage system (GE/S) to those of 10 Milky Way (MW) dwarf satellite galaxies: LMC, SMC, Boötes I, Carina, Draco, Fornax, Sagittarius, Sculptor, Sextans, and Ursa Minor. Our main focus is on the distributions o

Background: OSA is a common sleep-breathing disorder linked to increased risk of cardiovascular disease. Intermittent upper airway obstruction and hypoxia, hallmarks of OSA, have been shown in animal models to induce substantial changes to the gut microbiota composition, and subsequent transplantation of fecal matter to other animals induced changes in BP and glucose metabolism. Research Question:

Context. Reconstructing how all the stellar components of the Galaxy formed and assembled over time by studying the properties of the stars that form it is the aim of Galactic archaeology. Thanks to the launch of the ESA Gaia astrometric mission and the development of many spectroscopic surveys in recent years, we are for the first time in the position to delve into the layers of the past of the G

The high-prevalence blood group antigen, Sda, had been puzzling blood bankers and transfusionists for at least a decade when it was reported in 1967. The characteristic mix of agglutinates and free red blood cells (RBCs), caused by anti-Sda, is seen with the RBCs from 90 percent of individuals of European descent. However, only 2-4 percent of individuals are truly Sd(a-) and may produce anti-Sda.

The management of breast cancer during pregnancy (PrBC) is a relatively rare indication and an area where no or little evidence is available since randomized controlled trials cannot be conducted. In general, advances related to breast cancer (BC) treatment outside pregnancy cannot always be translated to PrBC, because both the interests of the mother and of the unborn should be considered. Eviden