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Elucidating the molecular mechanisms behind the behavioural manipulation of ‘zombie’-flies by the entomopathogenic fungus, Entomophthora muscae

The basal fungus Entomophthora muscae is an obligate insect pathogen specific to adult dipterans such as Musca domestica. It is ostensibly regarded as a parasite that induces aberrant behaviour in the host species which is adaptive to the fungus at the expense of the host. Specifically, during the later stages of infection flies exhibit a behaviour sequence just prior to death which is considered

SVenX: A highly parallelized pipeline for structural variation detection using linked read whole genome sequencing data

Genomic rearrangements larger than 50 bp are called structural variants. As a group, they affect the phenotypic diversity among humans and have been associated with many human disorders including neurodevelopmental disorder and cancer. Recent advances in whole genome sequencing (WGS) technologies have made it possible to identify many more disease-causing genetic variants relevant in clinical diag

An experimental analysis regarding neural bases of hand synergies during reach-to-grasp movements

Få grepp om hjärnan Området i hjärnan som styr händerna och uppfattar känsel i dem är väldigt stort jämfört med andra områden. Skador i den delen av hjärnan, som kan bero på sjukdomar eller olyckor, orsakar ofta problem med att utföra vardagliga handrörelser. Problemen kan minska mycket med hjälp av specifik rörelseträning, men vi vet än idag inte hur vi på bästa sätt ska utforma rörelseträningenTraumatic brain injury and diseases causing cortical damage is a global problem. Despite their vast extent, their pathophysiology is poorly understood. It is however known that the loss of motor functions can be regained thanks to adaptive properties of the neuronal system. Early task specific motor training is proven to be critical for rehabilitation. We set out to better understand how the CNS c

Body Painting and Insect Attraction: A Look at Culture as Adaptation

Horse flies and other biting Diptera are not only annoying pests, but can inflict numerous diseases on the people and animals they bite. Studies in recent years have shown horse flies are less attracted to striped surfaces, providing evidential support that zebra stripes have evolved as biting fly protection. The Omo River Valley tribes in the historical zebra range of southwest Ethiopia regularly

Hantering av sociala risker i fysisk planering – Utveckling av en metod för social riskhantering i detaljplaneprocessen

Fysiska förändringar i redan bebyggda områden har i vissa fall visat sig vara problematiskt, inte minst med hänsyn till påverkan på det sociala livet. För att möta behovet av den ökade befolkningen i Sverige idag är förtätning ett alternativ för att inte ta värdefull mark i anspråk, vilket innebär att det byggs tätare och högre i redan bebyggda områden. Vid sådana fysiska förändringar är det därföWith the need for housing in Sweden high and steadily growing, there is now more emphasis than before on urban expansion in cities. Built areas consist of social relationships, structures and contacts which can be described as social risks when they lead to negative effects. Social effects are altered by changes in the physical environment, which is why it is essential to properly plan out these e

Applying concurrent engineering in an established multi-site companya concurrent process for a developing and manufacturing company’s new product introduction in production.

Background As new product development is becoming more important due to higher and more global competition the new product introduction process needs to be efficient in order to launch new products before they become obsolete. Therefore, a more efficient development process with integrated functions is needed. Concurrent engineering claims to be this and has support in much research. However, conc

How to apply Activity-Based Costing on a brand level in a multi-brand portfolio

Background Activity-Based Costing is a costing method arisen in 1980’s as a response to changed cost structures. As business had become less labour intensive, Kaplan and Johnson argued that the traditional management accounting methods, using direct labour as cost base, were out-dated. Instead, Activity-Based Costing is based on the costs for the activities that the products require. The methodolo

Etablering på en relationsorienterad marknad

Fallföretaget har, vid starten av examensarbetet, bestämt sig för att träda in på hotellmarknaden. Götessons är idag en etablerad aktör på kontorsmarknaden, men de ser att det kan finnas risk för att efterfrågan på deras produkter avtar på den här marknaden. De har planerat att etablera sig på hotellmarknaden genom att använda sig av tillväxtstrategin marknadsutveckling, alltså genom att använ

Camera Interaction in Elevator Environment

Examensarbetets uppsats beskriver en produktutvecklingsprocess, syftet är att utveckla ett produktkoncept för en övervakningskamera i en hissmiljö. Studien är genomförd på uppdrag av Axis Communications AB, ett marknadsledare företag inom nätverksvideo. Uppsatsen inkluderar en omfattande bakgrundsstudie, i vilken syftet är att skapa förståelse för relevanta delar av hissbranschen för att få kunskThis master thesis describes a product development process with the aim of developing a product concept for a surveillance camera in an elevator environment. The study is conducted on behalf of Axis Communications AB, a market leading company in network camera solutions. The thesis includes a comprehensive background study that seeks to understand relevant parts of the elevator business to gain k

Implications of Change Management

Date of Seminar: 2018.01.11 Supervisor: Devrim Göktepe-Hultén Key words: Change management, change process, Shape 2020, Shape & Share Purpose: The purpose of this thesis is to investigate how Cramo AB works with change management and if they succeed or not, by using Kotter’s model as an analytic tool and other theoretical perspectives of change management. Methodology: The research is con

In-plane fracture analysis of paperboard using x-ray tomography

In this Master's Thesis x-ray tomography was used during tensile experiments on paperboard to study delamination and cohesive failure. Digital volume correlation of the x-ray tomograph images enabled quantitative analysis of strain fields. Tensile experiments on different specimen geometries were also conducted to investigate how the geometry affected the response of the specimens during load

Lojalitetsprogram i resebranschen - skillnader och likheter i strukturer och värde

Vi identifierade faktorer som alla intervjuade företag har gemensamt i termer av struktur, värde och till sist värde genom struktur. Exempelvis utför företagen sitt förändringsarbete snarligt varandra (struktur), lojalitetsprogrammen skapar mer återkommande kunder i samtliga fall (värde) och samtliga fall har samarbetspartners för att öka värdet för kunden (värde genom struktur).We identified factors that all interviewed firms have in common in terms of structure, value and lastly value through structure. For an example, all cases conduct their change processes in a similar way (structure), the loyalty programs create more returning customers for all cases (value) and all cases have cooperation partners that increase the value for customers (value through structure).

Generation and optimization of cellular models for investigation of mechanisms underlying Parkinson´s disease

Celler som modeller Parkinsons sjukdom är en neurologisk åkomma som mestadels drabbar den äldre befolkningen. Proteinet alfa-synukelin tros ha stor påverkan på mekanismer i hjärnans celler och således på sjukdomsprocessen. För att bota denna sjukdom krävs därför mera forskning om alfa-synukelin. I detta projekt har celler använts för att undersöka detta. Parkinsons sjukdom uppstår på grund av aParkinson’s disease (PD) is considered one of the most frequent neurodegenerative disorders amongst elderly people. PD leads to loss of dopaminergic neurons in substantia nigra of the brain giving symptoms such as slowness of movement and dementia. PD brains have been found to contain accumulations of a protein named alpha‐synuclein (α‐syn). Additional to its aggregation propensity in PD it is als

Conservation of saproxylic beetles in a wooded pasture in northern Scania

The area of wooded pasture in Europe has decreased drastically over the last centuries due to abandoned management. Herrevadskloster is a newly formed nature reserve in northern Scania with an unusually long continuity of being an open, grazed woodland containing large old trees. In this study, the reserve was studied to evaluate its potential to further the conservation of the redlisted saproxyli

Vad behövs för att fungera? - En studie om förutsättningar på Sparbanken Skånes HR-avdelning

Denna kandidatuppsats kartlägger med hjälp av en kvalitativ intervjustudie vilka förutsättningar HR-avdelningen på Sparbankens Skåne anser som väsentliga för deras möjlighet till att fungera väl. Studien har genomförts med hjälp av ett hermeneutiskt perspektiv och en abduktiv ansats. Med hjälp av fem semistrukturerade intervjuer samlades empiriskdata in för att sedan analyseras med hjälp utav kodn

Fabrication of Tunneling Field Effect Transistors (TFETs) and the study of graphene

After the discovery of graphene in 2004, a single layer of graphite, the assembly of 2D materials became a promising research area in solid state Physics. This thesis explores fabrication of 2D-heterostructures that aim to probe into graphene’s electronic structure with the Tunneling Field Effect Transistor (TFET). In the fabrication process, we used mechanical exfoliation to obtain monolayer gra