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Exposure to wear particles generated from studded tires and pavement induces inflammatory cytokine release from human macrophages

Health risks associated with exposure to airborne particulate matter (PM) have been shown epidemiologically as well as experimentally, pointing to both respiratory and cardiovascular effects. Lately, wear particles generated from traffic have been recognized to be a major contributing source to the overall particle load, especially in the Nordic countries were studded tires are used. In this work,

Educative assessment for/of teacher competency. A study of assessment and learning in the "Interactive examination" for student teachers.

Popular Abstract in Swedish Syftet med den här avhandlingen är att studera några av de problem som är förknippade med implementering av så kallad autentisk bedömning i lärarutbildningen. I den första delen av avhandlingen undersöks, genom en litteraturöversikt, huruvida användningen av bedömningsmatriser kan fungera som ett stöd för ökad tillförlitlighet och trovärdighet vid bedömning av komplexa The aim of this dissertation is to explore some of the problems associated with introducing authentic assessment in teacher education. In the first part of the dissertation the question is investigated, through a literature review, whether the use of scoring rubrics can aid in supporting credible assessment of complex performance, and at the same time support student learning of such complex perfo

Connecting Social Science and Information Technology through an Interface-Centric Framework of Analysis.

The gathering pace of IT innovation has, or ought to have had notable methodological repercussions for the social-science community (and beyond). Where yesterday the researcher could unhurriedly unlock the social-scientific significance of a chosen medium, secure in the knowledge that his or her work would have bearing for many years, by now there is every reason to confront a fear that the prodde

Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).

Metabolites generated from fuel metabolism in pancreatic beta-cells control exocytosis of insulin, a process which fails in type 2 diabetes. To identify and quantify these metabolites, global and unbiased analysis of cellular metabolism is required. To this end, polar metabolites, extracted from the clonal 832/13 beta-cell line cultured at 2.8 and 16.7 mM glucose for 48 h, were derivatized followe

Behavioural repertory of cats without cerebral cortex from infancy

Bilateral removal of the cerebral cortex was made in cats neonatally. Spontaneous and imposed behaviour was studied while they were growing up and after they had become adult. Special emphasis was put on the utilization of visual cues and on learning. The cats ate, drank and groomed themselves adequately. Adequate maternal and female sexual behaviour was observed. They utilized the visual and hapt

Process development and characterization of antisticking layers on nickel-based stamps designed for nanoimprint lithography

Thin films of different derivatives of fluorinated alkyl phosphoric acids have been deposited from aqueous solutions onto surfaces of oxidized polycrystalline nickel stamps. which are commonly used in several industrial applications of nanoimprint lithography (NIL). The films have been established in order to increase the antiadhesion tendencies at the stamp polymer interface. Thicknesses, chemica

Sertindole: efficacy and safety in schizophrenia

Sertindole is an antipsychotic drug with affinity for dopamine D, serotonin 5-HT2A and 5-HT2C, and alpha(1)-adrenoreceptors. Preclinical studies suggest that sertindole acts preferentially on limbic and cortical dopaminergic neurons and clinical trials have confirmed that sertindole is effective at a low cloparnine D-2 occupancy level. The active substance has a long half-life. Oral administration

Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study

Introduction A study was undertaken to test the hypothesis that musculoskeletal pain is associated with low vitamin D levels but the relationship is explained by physical inactivity and/or other putative confounding factors. Methods Men aged 40-79 years completed a postal questionnaire including a pain assessment and attended a clinical assessment (lifestyle questionnaire, physical performance tes

Non-thermal production of pure hydrogen from biomass: HYVOLUTION

The objectives and methodology of the EU-funded research project HYVOLUTION devoted to hydrogen production from biomass are reviewed. The main scientific objective of this project is the development of a novel two-stage bioprocess employing thermophilic and phototrophic bacteria, for the cost-effective production of pure hydrogen from multiple biomass feedstocks in small-scale, cost-effective indu

Three-dimensional imaging of whole mouse models: comparing nondestructive X-ray phase-contrast micro-CT with cryotome-based planar epi-illumination imaging

In this study, we compare two evolving techniques for obtaining high-resolution 3D anatomical data of a mouse specimen. On the one hand, we investigate cryotome-based planar epi-illumination imaging (cryo-imaging). On the other hand, we examine X-ray phase-contrast micro-computed tomography (micro-CT) using synchrotron radiation. Cryo-imaging is a technique in which an electron multiplying charge

Gated Tunnel Diode with a Reactive Bias Stabilizing Network for 60 GHz Impulse Radio Implementations

We report on a gated tunnel diode (GTD) and its operation in a 60 GHz pulsed oscillator, also known as a wavelet generator. The wavelet generator operates with the aid of a reactive bias stabilizing network, which minimizes the DC power consumption. This allows for 60 GHz wavelets as short as 56 ps to be produced, with a corresponding energy consumption of 1.0 pJ, which is a factor of 3.6 lower as

Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks

Fibrillin-containing microfibrils are polymeric structures that are difficult to extract from connective tissues. Proteolytic digestion of tissues has been utilized to release microfibrils for study. Few of the molecules that connect microfibrils to other elements in the matrix have been identified. In this study, electron microscopic immunolocalization of anti-versican antibodies in tissues and i

Dynamic start-up optimization of a plate reactor with uncertainties

In this paper, start-up of a plate reactor with an exothermic reaction is considered. Dynamic optimization is used to obtain start-up trajectories, while a feedback control system is designed for on-line control. The problem is challenging, since the process model is highly nonlinear, and subject to uncertainty. Limited bandwidth of the feedback control system requires that the optimization gives

Self-assembly in some N-lauroyl-L-glutamate/water systems

Acylglutamate is a divalent anionic surfactant whose properties are affected by its degree of neutralization. In this study, we present phase maps for aqueous systems of the potassium (LGP) and triethanolamine salts (LGT) of N-lauroyl L-glutamic acid, at different degrees of neutralization. A cubic phase forming between the isotropic micellar and the hexagonal phase was detected in both LGP/water