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The present review covers a wide scope of occupational heat stress related issues. The problematics related to climate change have placed heat exposure on the agenda. As a result, the research on heat effects has increased in recent years and a considerable amount of new material has become available. The literature includes general and specific reviews that focus on various heat-related aspects i
In this work the cutting tool temperature distribution that develops during turning of hardened cold-work tool steel is modeled on the basis of experimental data. The data obtained from a series of thermocouples, placed on a PCBN insert, into an anvil, and into a toolholder, were used as the input for the model. An inverse problem was solved, where the heat fluxes were computed. The temperature di
Entrepreneurship is an emerging research field that received an increased worldwide scholarly attention during the last few decades. Although the field is still dominated by scholars in the US and Europe, researchers in other parts of the world are exhibiting a growing interest. Based on the globalization of entrepreneurship research over the last decades, this book chapter aims to understand the
Introduction: The aim of this study was to evaluate the frequencies of nonsurgical retreatment, root-end surgery, extraction, and further restoration of root-filled teeth in Sweden in 2009 during a follow-up period of 5 years and to compare the outcomes in teeth restored with direct or indirect restorations. Methods: Data from the Swedish Social Insurance Agency were analyzed, and the frequencies
The common practice of using general concepts as tools in legal reasoning is bound to raise questions concerning the relative importance of the general and the specific for the understanding of international law. To illustrate, this article uses two judgments handed down by the icty Trial Chamber. While for both judgments, the Chamber inferred from human rights instruments an alleged general conce
Initial exertion of self-control has been suggested to impair subsequent self-regulatory performance. The specific cognitive processes that underlie this ego depletion effect have rarely been examined. Drawing on the dual-process theory of executive control (Engle & Kane, ; Kane & Engle, ), the current meta-analysis revealed that initial self-control exertion impairs participants' capaciti
Background: For parents, having a child admitted to a paediatric intensive care unit (PICU) is a very stressful experience filled with anxiety. Parents are often scared and traumatised. This stress can lead to PTSD. Aim: The aim was to describe parents' experiences and the effect on the family two years after their child was admitted to a paediatric intensive care unit. Material and methods: Ten p
Aim: Longitudinal ventricular contraction is a parameter of cardiac performance with predictive power. Right ventricular (RV) longitudinal function is impaired in patients with free pulmonary regurgitation (PR) following corrective surgery for Tetralogy of Fallot (TOF). It remains unclear whether this is a consequence of the surgical repair, or whether it is inherent to PR. The aim of this study w
In this study, numerical simulations are conducted to investigate the effects of pin fin location, pin fin diameter, and pin fin shape on the target and pin fin surfaces heat transfer as well as friction factor in an improved Lamilloy cooling structure. The pin fin normalized location is varied from 0.35 to 0.65 while the pin fin diameter is changing from 15 mm to 60 mm. Cone-shaped pin fins are i
The small heat shock protein (sHsp) chaperones are crucial for cell survival and can prevent aggregation of client proteins that partially unfold under destabilizing conditions. Most investigations on the chaperone activity of sHsps are based on a limited set of thermosensitive model substrate client proteins since the endogenous targets are often not known. There is a high diversity among sHsps w
To meet the economic requirements of power output, the increased inlet temperature of modern gas turbines is above the melting point of the material. Therefore, high-efficient cooling technology is needed to protect the blades from the hot mainstream. In this study, film cooling was investigated in a simplified channel. A bulge located upstream of the film hole was numerically investigated by anal
Despite many major advances in recent years, three key challenges remain in bringing clarity to the early history of the phylum: (1) identifying the origin, morphology and life modes of the first brachiopods; (2) understanding the relationships of the major groups to each other and higher sister taxa; and (3) unravelling the roles of the Cambrian and Ordovician radiations that set the agenda for m
Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities.
Polyphenols are one of the most common groups of secondary metabolites in plants and thought to play a key role in enhancing plant fitness by protecting plants against enemies. Although enemy-inflicted mortality at the seed stage can be an important regulator of plant populations and a key determinant of community structure, few studies have assessed community-level patterns of polyphenol content
Assessment of programmed cell death ligand 1 (PD-L1) immunohistochemical staining is used for decision on treatment with programmed cell death 1 and PD-L1 checkpoint inhibitors in lung adenocarcinomas and squamous cell carcinomas. This study aimed to compare the staining properties of tumor cells between the antibody clones 28-8, 22C3, SP142, and SP263 and investigate interrater variation between
Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibili
