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Dark excited states of carotenoids: Consensus and controversy

Excited-state dynamics of carotenoids has attracted considerable recent interest, but it has also engendered a number of controversial hypotheses. This review summarizes the knowledge gathered from various ultrafast time-resolved techniques addressing the two most discussed dark excited states (1B(u)(-) and S*). These two states have been subjects of numerous earlier studies, because while the 1B(

A phylogenetic analysis of xanthorioid lichens (Teloschistaceae, Ascomycota) based on ITS and mtSSU sequences

A phylogenetic analysis of xanthorioid lichens of the lichen family Teloschistaceae, based on ITS rDNA and mtSSU sequences, is presented. The data set includes 201 specimens representing 50 species, covering the xanthorioid lichen group, which resulted in 183 new sequences. Five well-supported groups were recognized in the MP analysis: 1) Seirophora, 2) the Xanthoria s. str.-Xanthodactylon group,

Microvascular plasticity and neurovascular coupling in the pharmacotherapy of Parkinson's disease

Popular Abstract in Swedish Parkinsons sjukdom är en av våra mest förekommande neurologiska sjukdomar som drabbar den åldrande befolkningen. I åldersgruppen 50-60 år drabbas ca 1 procent av sjukdomen, som karakteriseras av de motoriska symptomen stelhet, långsamma rörelser och skakningar. Symptomen beror på en gradvis förlust av nervceller i en djup del av hjärnan vid namn substantia nigra (den svL-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. The causes behind dyskinesia are not completely understood, but intense research has identified a number of neuronal alterations associated with L-DOPA-induced dyski

HAMLET interacts with lipid membranes and perturbs their structure and integrity.

BACKGROUND: Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded alpha-lactalbumin (HLA) and oleic acid that is internalized by tumor cells, suggesting that interactions with the phospholipid bilayer and/or spe

Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.

Alterations in the scaffold protein WRAP53β have previously been linked to carcinogenesis and, in particular, associated with an increased risk for epithelial ovarian cancer. Here, we investigated the pathogenic impact and prognostic significance of WRAP53β in connection with epithelial ovarian cancer and examined the underlying mechanisms. We find that reduced expression of WRAP53β in ovarian tum

Presence of Eriophorum scheuchzeri enhances substrate availability and methane emission in an Arctic wetland

Here we present results from a field experiment in an Arctic wetland situated in Zackenberg, NE Greenland. During one growing season we investigated how dominance of the sedge Eriophorum scheuchzeri affected the below-ground concentrations of low molecular weight carbon compounds (LMWOC) and the fluxes of CO2 and CH4 in comparison to dominance of other sedges (Carex stans and Dupontia psilosantha)

Frans G. Bengtssons lyrik

The poems of Frans G Bengtsson are analyzed first as produced from the viewpoint of Schopenhauer's radical pessimism,and Bengtsson´s serious illness. The poems formal and thematic characters are scrutinized: the formal excellence is conceived as a manifestation of a kantian aesthetic, also as a mark of Bengtsson's extreme objectivism, his inclination towards the factual. The most dominant theme in

Europe Refracted: Western Education and Knowledge in China

European educational knowledge and practices have been deeply impacted by the colonial experience. While hegemonic knowledge was exported to the colonies, practices of teaching and governing colonial subjects were tested in the periphery and then re-imported to the center. This contribution looks at a case of European education outside Europe that did not take place, at least not entirely, in a co

Environmental proxies of antigen exposure explain variation in immune investment better than indices of pace of life

Investment in immune defences is predicted to covary with a variety of ecologically and evolutionarily relevant axes, with pace of life and environmental antigen exposure being two examples. These axes may themselves covary directly or inversely, and such relationships can lead to conflicting predictions regarding immune investment. If pace of life shapes immune investment then, following life his

Measurement of Tumor Extent and Effects of Breast Compression in Digital Mammography and Breast Tomosynthesis

Popular Abstract in Swedish Bröstcancer är den typ av cancer som drabbar flest kvinnor i Sverige. Årligen diagnostiseras drygt 7000 kvinnor med bröstcancer och ungefär 1400 dör av sin sjukdom. För att minska bröstcancerdödligheten rekommenderar Socialstyrelsen mammografiscreening där kvinnor över 40 år bjuds in för regelbundna kontroller. Dessa kontroller utförs med digital mammografi som innebär Breast cancer is the most common form of cancer affecting women in the western countries. Today x-ray digital mammography (DM) of the breast is commonly used for early detection of breast cancer. However, the sensitivity of mammography is limited, mainly due to the fact that a 3D volume is projected down to a 2D image. This problem can be partially solved by a tomographic technique. Breast tomosyn

A search for new physics in dijet mass and angular distributions in pp collisions at root s=7 TeV measured with the ATLAS detector

A search for new interactions and resonances produced in LHC proton-proton (pp) collisions at a centre-of-mass energy root s = 7 TeV was performed with the ATLAS detector. Using a dataset with an integrated luminosity of 36 pb(-1), dijet mass and angular distributions were measured up to dijet masses of similar to 3.5 TeV and were found to be in good agreement with Standard Model predictions. This

Budesonide Prevents Cytokine-Induced Decrease of the Relaxant Responses to Formoterol and Terbutaline, but Not to Salmeterol, in Mouse Trachea

During asthma exacerbations, increased airway inflammation may impair the effects of beta(2)-adrenoceptor (beta(2)AR) agonists. It is unclear whether this impairment is prevented by inhaled glucocorticoids (GCs). We have investigated the relaxation of carbachol-contracted mouse tracheal segments to the beta(2)AR agonists formoterol, terbutaline, and salmeterol. The segments were pre-exposed for 4

"För två ostburgare och en Coca-Cola” : Anteckningar om den europeiska film- och TV-produktionens omflyttningar efter 1989

This article is a basically a compare and contrast study regarding two different lines of development with regard to the film and television production which has taken place in Europe during the last three decades. On the one hand it examines and evaluates the phenomenon that is the rampant rise of runaway production of international film and television and which has predominantly occurred in East

Low ERK Phosphorylation in Cancer-Associated Fibroblasts Is Associated with Tamoxifen Resistance in Pre-Menopausal Breast Cancer

Purpose: The aim of this study was to evaluate ERK phosphorylation as a stromal biomarker for breast cancer prognosis and tamoxifen treatment prediction within a randomized tamoxifen trial. Patients and Methods: Tissue microarrays of two breast cancer cohorts including in total 743 invasive breast cancer samples were analyzed for ERK phosphorylation (pERK) and smooth muscle actin-alpha expression

Fire evacuation in high-rise buildings: a review of human behaviour and modelling research

A review of literature related to fire evacuation in high-rise buildings was carried out with the following objectives, (1) to identify the key behavioural factors affecting the performance of people during a fire in a high-rise building, the singularities associated to this type of buildings and areas of future research; (2) to review the procedures and strategies currently adopted in high-rise b