BACKGROUND: There are important unmet clinical needs to develop cell enrichment technologies to enable unbiased label-free isolation of both single cell and clusters of circulating tumor cells (CTCs) manifesting heterogeneous lineage specificity. Here, we report a pilot study based on microfluidic acoustophoresis enrichment of CTCs using the CellSearch CTC assay as a reference modality.METHODS: Ac

One way to facilitate electrochemical communication between bacterial cells and electrodes is the use of artificial redox mediators. There are, however, a number of drawbacks when they are used in their freely diffusing monomeric form. In contrast when bound to flexible polymeric backbones they not only serve as mediators but also as an immobilization matrix forming a 3D hydrogel on the electrode

The measurement of the transport of scalar quantities within flows is oftentimes laborious, difficult or even unfeasible. On the other hand, velocity measurement techniques are very advanced and give high-resolution, high-fidelity experimental data. Hence, we explore the capabilities of a deep learning model to predict the scalar quantity, in our case temperature, from measured velocity data. Our

This paper reports on efforts to create a robotized construction build system, based on the Finja Exakt manual build system. The equipment used is a generic off-the-shelf industrial arm robot integrated with a spindle crane carrier for mobility. The approach offers technical, safety and usability challenges as well as integration and business challenges for placing a generic industrial robot onsit

Background: Proton radiotherapy (RT) is an attractive tool to deliver local therapy with minimal dose to uninvolved tissue, however, not suitable for all patients. The aim was to explore complications, especially severe late complications (grades 3–4), following proton RT delivered to a complete Swedish cohort of paediatric patients aged

Background: Successful radioiodine treatment of differentiated thyroid cancer requires iodine avidity: that is, the concentration and retention of iodine in cancer tissue. Several parameters have previously been linked with lower iodine avidity. However, a comprehensive analysis of which factors best predict iodine avidity status, and the magnitude of their impact, is lacking. Methods: Quantitativ

Even among the most irradiated gas giants, so-called ultra-hot Jupiters, KELT-9b stands out as the hottest planet thus far discovered with a dayside temperature of over 4500 K. At these extreme irradiation levels, we expect an increase in heat redistribution efficiency and a low Bond albedo owed to an extended atmosphere with molecular hydrogen dissociation occurring on the planetary dayside. We p

The present study focused on a Chinese reality show, Forget Me Not Café, which brought together five older people (aged 65 and older) living with dementia to run a pop-up restaurant and intended to reduce the stigma of dementia. The study aims to explore how the reality-show participants describe dementia in older people and how their views relate to the macrosocial context of dementia and older p

High-spin states in 3676Kr40 have been populated in the 40Ca(40Ca,4p)76Kr fusion-evaporation reaction at a beam energy of 165 MeV, and studied using the GAMMASPHERE and MICROBALL multi-detector arrays. The ground-state band and two signature-split negative-parity bands of 76Kr have been extended to ∼30hℏ. Lifetime measurements using the Doppler-shift attenuation method indicate that the transition

With an aging population, an increased burden is put on national and regional healthcare and social systems. In Sweden, municipalities are required to provide inhabitants with the social services needed to enable them to live an independent life in their own home for as long as possible. Urban green spaces (UGS) may increase physical activity and social interaction, as well as improve wellbeing an

This presentation explores the potential benefits of Augmented Reality (AR) and Virtual Reality (VR) applications for promoting tourism and place branding.The presentation is framed within the context of place branding – which refers to the process of creating and managing a place’s image to attract tourists, investors, and residents (Moilanen & Rainisto, 2009) – and also draws upon experienti

When blame is understood to be emotion-based or affective, its emotional tone is standardly identified as one of anger. We argue that this conception of affective blame is overly restrictive. By attending to cases of blame that emerge against a background of a particular kind of hope invested in others, we identify a blaming response characterized not by anger but by sadness: reactive disappointme

In this paper, we revisit the rotation averaging problem applied in global Structure-from-Motion pipelines. We argue that the main problem of current methods is the minimized cost function that is only weakly connected with the input data via the estimated epipolar geometries. We propose to better model the underlying noise distributions by directly propagating the uncertainty from the point corre

Objective: To develop a reliable and valid short form of the State Anxiety Subscale of the State-Trait Anxiety Inventory for Children (STAI-CH) in the Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: A Development Sample of 842 10-year-old TEDDY children completed the STAI-CH State Subscale about their type 1 diabetes (T1D) risk. The best 6 items (three anxiety-present a

The network audio-visual entrepreneurship in China has achieved great progress and engendered conspicuous negative externalities in the early development stage. Few studies have investigated how media entrepreneurship coordinates with government regulation and the influence of government regulation on media entrepreneurship. This study aims at investigating government regulation on the flourishing