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Influence of order and type of drug (bisoprolol vs. enalapril) on outcome and adverse events in patients with chronic heart failure: a post hoc analysis of the CIBIS-III trial

Aims Angiotensin-converting enzyme inhibitors (ACE-Is) and beta-blockers are associated with improved outcome in patients with chronic heart failure (CHF). In this post hoc analysis of the CIBIS III trial, we examined the influence of the order of drug administration on clinical events and achieved dose. We also assessed the relations between dose levels and baseline variables or adverse events. M

Social Identity and Mobility at a Pre-industrial Mining Complex, Sweden

The early modern period has so far received little attention from archaeologists and anthropologists in Sweden. This study explores demographic patterns, social differences, family structure and mobility in a 16th-century skeletal population (n=102) from a preindustrial mining community (Salberget) in Bergslagen, Sweden, using a bioarchaeological perspective. Methodologically, the results of stron

Biharmonic maps into a Riemannian manifold of non-positive curvature

We study biharmonic maps between Riemannian manifolds with finite energy and finite bi-energy. We show that if the domain is complete and the target of non-positive curvature, then such a map is harmonic. We then give applications to isometric immersions and horizontally conformal submersions.

Simulation of Ductile Fracture of Slabs Subjected to Dynamic Loading Using Cohesive Elements

Dynamic loading of elastic-plastic slabs is studied numerically using a finite element approach, where introduction of cohesive elements enables fracture. For the bulk material, J(2)-flow theory is chosen as constitutive model, whereas the behavior of the cohesive elements is described by an irreversible cohesive law. The fracture behavior is governed solely by the cohesive elements, which are inc

Measurement of charged-particle event shape variables in inclusive root(s)=7 TeV proton-proton interactions with the ATLAS detector

The measurement of charged-particle event shape variables is presented in inclusive inelastic pp collisions at a center-of-mass energy of 7 TeV using the ATLAS detector at the LHC. The observables studied are the transverse thrust, thrust minor, and transverse sphericity, each defined using the final-state charged particles' momentum components perpendicular to the beam direction. Events with at l

Summary of the searches for squarks and gluinos using root s=8 TeV pp collisions with the ATLAS experiment at the LHC

A summary is presented of ATLAS searches for gluinos and first- and second-generation squarks in final states containing jets and missing transverse momentum, with or without leptons or b-jets, in the root s = 8 TeV data set collected at the Large Hadron Collider in 2012. This paper reports the results of new interpretations and statistical combinations of previously published analyses, as well as

Development and validation of a new automatic algorithm for quantification of left ventricular volumes and function in gated myocardial perfusion SPECT using cardiac magnetic resonance as reference standard.

BACKGROUND: By gating image acquisition in myocardial perfusion SPECT (MPS) to ECG, left ventricular (LV) volumes and function can be determined. Several previous studies have shown that existing MPS software packages underestimate LV volumes compared to cardiac magnetic resonance (CMR). The aim of this study was therefore to develop a new LV segmentation algorithm for gated MPS using CMR as refer

STrengthening the reporting of OBservational studies in Epidemiology-Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

Advances in laboratory techniques have led to a rapidly increasing use of biomarkers in epidemiological studies. Biomarkers of internal dose, early biological change, susceptibility, and clinical outcomes are used as proxies for investigating the interactions between external and/or endogenous agents and the body components or processes. The need for improved reporting of scientific research led t

CSF neurofilament light differs in neurodegenerative diseases and predicts severity and survival.

We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

On the Shift Semigroup on the Hardy Space of Dirichlet Series

We develop a Wold decomposition for the shift semigroup on the Hardy space H-2 of square summable Dirichlet series convergent in the half-plane R(s) > 1/2. As an application we have that a shift invariant subspace of H-2 is unitarily equivalent to H-2 if and only if it has the form phi H-2 for some H-2-inner function phi.

Use of wall-less (18)F-doped gelatin phantoms for improved volume delineation and quantification in PET/CT.

Positron emission tomography (PET) with (18)F-FDG is a valuable tool for staging, planning treatment, and evaluating the treatment response for many different types of tumours. The correct volume estimation is of utmost importance in these situations. To date, the most common types of phantoms used in volume quantification in PET utilize fillable, hollow spheres placed in a circular or elliptical

Search for long-lived, weakly interacting particles that decay to displaced hadronic jets in proton-proton collisions at root s=8 TeV with the ATLAS detector

A search for the decay of neutral, weakly interacting, long-lived particles using data collected by the ATLAS detector at the LHC is presented. This analysis uses the full data set recorded in 2012: 20.3 fb(-1) of proton-proton collision data at root s = 8 TeV. The search employs techniques for reconstructing decay vertices of long-lived particles decaying to jets in the inner tracking detector an

Russia on display. Sochi-2014 as a project of belonging in contemporary media

Mediated mega-events are essentially projects of belonging: about imagining communities and about creating attachment to such collective selves. However, events like the Olympic Games are not only an opportunity for states to reinforce official constructions of belonging but can also be sites for the articulation and dissemination of contesting identity narratives. This article investigates Russia

Influence of hydrogen content on fracture toughness of CWSR Zr-2.5Nb pressure tube alloy

In this work, influence of hydrogen and temperature on the fracture toughness parameters of unirradiated, cold worked and stress relieved (CWSR) Zr-2.5Nb pressure tube alloys used in Indian Pressurized Heavy Water Reactor is reported. The fracture toughness tests were carried out using 17 mm width curved compact tension specimens machined from gaseously hydrogen charged tube-sections. Metallograph

Finite volume at two-loops in chiral perturbation theory

We calculate the finite volume corrections to meson masses and decay constants in two and three flavour Chiral Perturbation Theory to two-loop order. The analytical results are compared with the existing result for the pion mass in two-flavour ChPT and the partial results for the other quantities. We present numerical results for all quantities.

Cytogenetic and single nucleotide polymorphism array findings in soft tissue tumors in infants

Soft tissue tumors in children under one year of age (infants) are rare. The etiology is usually unknown, with external factors or congenital birth defects and hereditary syndromes being recognized in only a small proportion of the cases. We ascertained the cytogenetic findings in 16 infants from whom tumor tissue had been obtained during a 25-year period. In eight of them, single nucleotide polym