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CpG dinucleotides are efficiently methylated in vertebrate genomes except in the CpG islands having a high C+G content. Methylated CpGs are the single most mutated dinucleotide. Sequences surrounding disease causing CpG mutation sites were analyzed from locus-specific mutation databases. Both tetra- and heptanucleotide analyses indicated clear overall sequence preference for having pyrimidines 5'
Objective: To examine annual weight-development in a sample of 215 psychotic patients treated with risperidone over 5 years. Method: Naturalistic longitudinal study. Results: The sample was more obese than the general population at baseline, but also increased much more in mean body mass index over approximately the same time period, while patients off medication seemed to remain weight stable. Ex
Popular Abstract in Swedish Typ 2 diabetes är en sjukdom som ökar lavinartat i västvärlden. Dess främsta kännetecken är insulinresistens och defekter i insulinsekretion. Insulinresistens är kopplat till fetma, och framträder ofta långt innan man utvecklar typ 2 diabetes. När man blir insulinresistent kompenseras detta av att betacellerna i de langerhanska öarna i bukspottskörteln producerar mer inType 2 diabetes is a disease that increases tremendously in the western world. It is characterized by insulin resistance and defects in insulin secretion. Insulin resistance is tightly linked to obesity, and usually precedes the onset of type 2 diabetes. When insulin resistance develops, the pancreatic beta-cells compensate by in¬creasing their secretion of insulin, causing hyperinsulinemia. This
OBJECTIVE: to evaluate platelet and leukocyte activation during aortoiliac angiography and percutaneous transluminal angioplasty (PTA). METHODS: an observational study of 14 patients with aortoiliac atherosclerotic disease, nine of whom underwent PTA. The proportion of fibrinogen-, and P-selectin positive platelets, P-selectin expression on platelets, intraplatelet cGMP and cAMP, CD18 positive gra
The outbreak of highly pathogenic avian influenza of the H5N1 subtype in Asia, which has subsequently spread to Russia, the Middle East, Europe, and Africa, has put increased focus on the role of wild birds in the persistence of influenza viruses. The ecology, epidemiology, genetics, and evolution of pathogens cannot be fully understood without taking into account the ecology of their hosts. Here,
Since a psychiatric reform came into effect in Sweden in January 1995, municipalities have been responsible for the care of people with psychiatric illness who are no longer supposed to be in need of continuous medical care. In particular, the responsibility for assistance in independent or supported living and meaningful daily occupations was assigned to the municipalities. This reform implied th
Thermotoga maritima ribosome recycling factor (RRF) is one of the proteins catalyzing the fourth step in prokaryotic protein synthesis, ribosome recycling. The RRF protein was crystallized with ammonium sulfate. Native diffraction data to 2.55 Å resolution were obtained at the MAX II synchrotron from a flash-frozen crystal at 100 K. The crystals belong to space group P41212 or P43212, with unit-ce
Popular Abstract in Swedish Den dansk-svenske forfatter Gustaf Munch-Petersen (1912-1938) betragtes som en af portalskikkelserne i den danske lyriske modernisme. Han døde 26 år gammel som frivillig i den spanske borgerkrig, en konflikt, vi i dag ofte betragter som en del af optakten til anden verdenskrig. Dette tidlige endeligt gjorde ham til en af skandinavisk litteraturs ”unge døde”. Men det er The Danish-Swedish writer Gustaf Munch-Petersen (1912-1938) is considered one of the pioneers of Danish modernist poetry. His death at the age of 26 as a volunteer in the Spanish Civil War, a conflict that was later widely understood as a prelude to the Second World War, made him one of “the young dead” of Scandinavian literature. But this is only one among several pictures of him. Self and identi
This article argues for an intersectional multisolidarity with an anti-racist, queer and feminist agenda.
Studies of intermediate energy heavy ion reactions have revealed the existence of a number of reducibility and thermal scaling properties in nuclear multifragmentation. In particular, the probability of emitting n-fragments is reducible to the probability of emitting a single fragment through the binomial distribution. The resulting one-fragment probability shows a dependence on the thermal energy
Popular Abstract in Swedish "Behavioral Economics" är ett område inom nationalekonomin där forskningsresultat från främst psykologin inhämtas vid analys av ekonomiska fenomen, även om andra samhällsvetenskaper såsom socialpsykologi och sociologi också givit bidrag. Följande avhandling och dess fyra uppsatser undersöker delar av "Behavioral Economics" med särskild betoning på realism, ontologi och This thesis explores Behavioral Economics in terms of realism, ontology and experiments. In the introductory chapter descriptions of "Behavioral Economics", "realism" and "ontology" are offered. In the following three chapters meta-theoretical analyses are performed, while the fifth and last chapter is a report of an experiment but with a meta-theoretical undertone. In Chapter 2 two recent survey
In this document, a large number of mathematical models describing various physical, biological and chemical processes in a wastewater treatment plant are presented. In most cases, the models are fairly simple as they are inteded for steady-state simulations based on yearly averages of the influent wastewater charteristics. The combination of models forms a software tool namned URWARE (URban WAter
Human neutrophil peptide-1 (HNP-1) is a member of the alpha-defensin family. Defensins are cationic antimicrobial peptides, which play an important role in the antimicrobial response to microorganisms. In addition, recent studies have revealed the involvement of defensins in inflammation, immunity and wound repair. Defensins are present in the azurophilic granules of neutrophils and are released u
The increasing interest in the European historical log construction has heightened the need for comprehensive studies in different parts of the continent to view both the common features and the particular ones. The advanced Scandinavian research has revealed the problems of studying in depth and maintaining the log heritage when links to traditional carpentry are lost. One of the fortunate places
Two-step steam pretreatment of softwood on laboratory scale has previously been shown to result in higher yields than one-step steam pretreatment. In this study, these results are verified on a larger scale. In an industrial process filtration and washing of the material between the two pretreatment steps are difficult without release of pressure. A worst case without filtration or washing was thu
