Search results

Filter

Filetype

Your search for "*" yielded 530123 hits

Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding

The opportunistic pathogen Pseudomonas aeruginosa, a major cause of nosocomial infections, uses carbohydrate-binding proteins (lectins) as part of its binding to host cells. The fucose-binding lectin, LecB, displays a unique carbohydrate-binding site that incorporates two closely located calcium ions bridging between the ligand and protein, providing specificity and unusually high affinity. Here,

A registry-based observational study comparing emergency calls assessed by emergency medical dispatchers with and without support by registered nurses

Background: The requirement concerning formal education for emergency medical dispatcher (EMD) is debated and varies, both nationally and internationally. There are few studies on the outcomes of emergency medical dispatching in relation to professional background. This study aimed to compare calls handled by an EMD with and without support by a registered nurse (RN), with respect to priority leve

Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels

Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer’s disease (AD), but the specific brain pathological events related to the alteration in p-tau217 plasma levels are still largely unknown. Using immunostaining techniques of postmortem AD brain tissue, we show that p-tau217 is found

Miniaturization during a Silurian environmental crisis generated the modern brittle star body plan

Pivotal anatomical innovations often seem to appear by chance when viewed through the lens of the fossil record. As a consequence, specific driving forces behind the origination of major organismal clades generally remain speculative. Here, we present a rare exception to this axiom by constraining the appearance of a diverse animal group (the living Ophiuroidea) to a single speciation event rather

What do actors in child protection processes in Sweden know about children’s rights to participation and about talking to children?

Enhancing children’s participation in child protection is a frequent issue in social work. The aim of this article is to investigate the perceived knowledge and educational demands of actors in Sweden’s child protection system, regarding children’s right to participation and actors’ perceived ability to communicate with children. This article will try to answer two specific research questions: HowEnhancing children’s participation in child protection is a frequent issue in social work. The aim of this article is to investigate the perceived knowledge and educational demands of actors in Sweden’s child protection system, regarding children’s right to participation and actors’ perceived ability to communicate with children. This article will try to answer two specific research questions: How

What makes children learn how to swim? – health, lifestyle and environmental factors associated with swimming ability among children in the city of Malmö, Sweden

Background: Swimming ability among children in the city of Malmö, Sweden is strongly affected by socioeconomic differences. We investigated to what extent mediating health and lifestyle factors, such as children’s eating, sleeping and physical activity habits, as well as the characteristics of the social and working environment at both school and home, could explain the socioeconomic gradient in s

Effects of autism on 30-year outcome of anorexia nervosa

Background: Long-term consequences of comorbid autism spectrum disorder (ASD) in individuals with anorexia nervosa (AN) are inadequately investigated. Methods: In the 1980s, 51 adolescent-onset AN cases (AN group) and 51 matched controls (COMP group) were recruited from the community. They have been examined on five occasions. The four last assessments included the Morgan-Russell Outcome Assessmen

Single-cell population genetics and dispersal limitation of a bloom-forming microalga

Microalgal range expansions are increasing in frequency and magnitude worldwide mostly due to anthropogenic factors. However, they often remain unnoticed until mass development (algal blooms) occurs due to difficulties in detection when population densities are low. However, population genetic methods offer an approach to investigate these patterns. One such potentially expanding bloom-forming spe

High-resolution global population projections dataset developed with CMIP6 RCP and SSP scenarios for year 2010–2100

We present a novel, global 30 arc seconds (∼1 km at the equator) population projection dataset covering each year from 2010 to 2100 that is consistent with both country level population and gridded urban fractions from the Coupled Model Intercomparison Project 6 (CMIP6). While IPCC population projections until 2100 are available at country level for Socio-Economic Pathways (SSPs), land cover (incl

Associations between long-term exposure to low-level air pollution and risk of chronic kidney disease—findings from the Malmö Diet and Cancer cohort

Background: Associations between air pollution and chronic kidney disease (CKD) have been reported, but studies at low exposure levels and relevant exposure time windows are still warranted. This study investigated clinical CKD at low air pollution levels in the Swedish Malmö Diet and Cancer Cohort in different exposure time windows. Methods: This study included 30,396 individuals, aged 45–74 at e

Atrial Fibrillatory Rate Characterization Extracted from Implanted Cardiac Monitor Data

The aim of this study is to characterize atrial fibrillatory rate (AFR) extracted from a cohort of continuously monitored atrial fibrillation (AF) patients as function of episode duration and onset time. The f-wave signal used to compute the AFR was extracted from a single lead ECG strip of the AF episodes stored in an Implantable Cardiac Monitor (ICM) in a cohort of 99 patients. The f-wave signal

Non-Invasive Characterization of Atrio-Ventricular Properties during Atrial Fibrillation

The atrio-ventricular (AV) node is the primary regulator of ventricular rhythm during atrial fibrillation (AF). Hence, ECG based characterization of AV node properties can be an important tool for monitoring and predicting the effect of rate control drugs. In this work we present a network model of the AV node, and an associated workflow for robust estimation of the model parameters from ECG. The

Changes in RR Series Characteristics during Atrial Fibrillation : An AV Node Simulation Study

The atrioventricular node (AVN) plays an important role in rate control during atrial fibrillation (AF). To further our understanding of the AVN function in AF, we present a model-based study, relating AVN electrophysiological characteristics to changes in RR series characteristics observed during treatment with rate control drugs. The dual-pathway physiology of the AVN was modelled using a networ

Dacarbazine-vindesine versus dacarbazine-vindesine-cisplatin in disseminated malignant melanoma. A randomised phase III trial

In a multicentre phase III study of disseminated malignant melanoma performed in Sweden and Norway, 326 patients were randomised to receive treatment with the combination dacarbazine [DTIC] (D) and vindesine (V) with or without the addition of cisplatin (P). D was given intravenously (i.v.) at a dose of 250 mg/m2 days 1-5 every 4 weeks and V was given i.v. at a dose of 3.0 mg/m2 day 1 weekly. P wa

Imaging of tissue degeneration in knee osteoarthritis using magnetic resonance and synchrotron radiation

Osteoarthritis (OA) is a very common disease, especially in the knee. It is characterized by the breakdown of articular cartilage but involves all parts of the joint. OA is usually diagnosed at a late stage when the articular cartilage has begun to disappear. What happens before these macroscopic alterations is to alarge extent unknown. In this thesis the focus is on articular cartilage and menisc

Structural Changes in Monolayer Cobalt Oxides under Ambient Pressure CO and O2 Studied by In Situ Grazing-Incidence X-ray Absorption Fine Structure Spectroscopy

We have used grazing incidence X-ray absorption fine structure spectroscopy at the cobalt K-edge to characterize monolayer CoO films on Pt(111) under ambient pressure exposure to CO and O2, with the aim of identifying the Co phases present and their transformations under oxidizing and reducing conditions. X-ray absorption near edge structure (XANES) spectra show clear changes in the chemical state