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Detecting violations of sensory expectancies following cerebellar degeneration:

Two hypotheses concerning cerebellar function and predictive behavior are the sensory prediction hypothesis and the timing hypothesis. The former postulates that the cerebellum is critical in generating expectancies regarding forthcoming sensory information. The latter postulates that this structure is critical in generating expectancies that are precisely timed; for example, the expected duration

A study of estimation method for conduction band offset in semiconductor heterostructure by using triple-barrier resonant tunneling diodes

A method for evaluating a band offset of a heterojunction is proposed by measuring temperature dependence of current-voltage (I-V) characteristics in triple-barrier resonant tunneling diodes (TBRTDs). The method was applied for investigating a conduction band offset by using GaAs0.25P0.75/GaAs TBRTDs with thin strain heterobarriers grown by MOCVD and DeltaE(c) was estimated as 200-240 meV. In the

Abnormal urethral motor function is common in female stress, mixed, and urge incontinence.

Aim: To investigate the urethral motor function in incontinent women. Materials and Methods: The intraurethral pressure was measured continuously in the high-pressure zone of the urethra at rest and during repeated short squeezes around the microtip transducer catheter in a group of 205 women with clinically manifest urinary incontinence (severe), and compared with the findings of investigations i

This beauty should drink well for 10-12 years: A note on recommendations as semantic middles

This paper capitalizes on the types of portrayal of the event in recommendations of prime drinking time using data from wine tasting notes. It argues that the weakly deontic nature of recommendation fosters semantic middles, not only the middle construction proper such as This beauty should drink well for 10–12 years, but recommendation as such is characterized by a mid-degree of transfer of actio

Variational second-order Moller-Plesset theory based on the Luttinger-Ward functional

In recent years there have been some rather successful applications of a new variational technique for calculating the total energies of electronic systems. The new method is based on many-body perturbation theory and uses the one-electron Green function as the basic "variable" rather than the wave function of traditional variational calculations. It is the purpose of the present work to promote t

Buffer medium exchange in continuous cell and particle streams using ultrasonic standing wave focusing

A microfluidic strategy to perform buffer exchange of particle and cell suspensions in a continuous flow format on, chip is presented. Ultrasonic standing wave technology is utilized to confine particulate matter to the centre of a buffer exchange channel while particle free buffer is sequentially aspirated via capillaries that branch off from the buffer exchange channel. At each such branch, clea

Process-based estimates of terrestrial ecosystem isoprene emissions: incorporating the effects of a direct CO2-isoprene interaction

In recent years evidence has emerged that the amount of isoprene emitted from a leaf is affected by the CO2 growth environment. Many - though not all - laboratory experiments indicate that emissions increase significantly at below-ambient CO2 concentrations and decrease when concentrations are raised to above-ambient. A small number of process-based leaf isoprene emission models can reproduce this

Total heart volume variation throughout the cardiac cycle in man.

Variations in total heart volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors of total heart volume variation during the cardiac cycle in healthy volunteers with the use of MRI. Eight healthy volunteers were examined by MRI at rest. Changes in total cardiac volume throughout the c

Apolipoproteins A-I and B in obese children

Body mass index (BMI), the distribution of fat, birth weight, physical fitness, apolipoproteins (apo) A-I and B, total cholesterol (TC), and high-density lipoprotein cholesterol (HDLC) were studied in 38 obese 10- to 11-year-olds in comparison to 52 age-matched controls. Obese children had higher concentration of apo B and a lower apo A-I:B ratio. Significant correlations were found between (a) ap

Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast.

Low-glycemic index (GI) foods and foods rich in whole grain are associated with reduced risk of type 2 diabetes and cardiovascular disease. We studied the effect of cereal-based bread evening meals (50 g available starch), varying in GI and content of indigestible carbohydrates, on glucose tolerance and related variables after a subsequent standardized breakfast in healthy subjects (n = 15). At br

Effect of set-up uncertainties on the dose distribution in the match region of supraclavicular and tangential breast fields

BACKGROUND: The objective of this paper is to illustrate the effect of a gap of 5 mm, an overlap of 5 mm and a perfect match on the dose distribution across the junction of tangential breast fields and adjacent supraclavicular and axillary fields. MATERIALS AND METHODS: For this purpose film dosimetry was applied to measure relative dose distributions in two sagittal planes in an anthropomorphic b

The influence of N load and harvest intensity on the risk of P limitation in Swedish forest soils

Nitrogen (N) is often considered to be the major factor limiting tree growth in northern forest ecosystems. An increased N availability, however, increases the demand for other nutrients such as base cations and phosphorous (P) which in turn may change which nutrient is the limiting factor. If P or base cations become limiting, N will start to leach which means a risk of increased eutrophication o

The Effect of Having an Affected Parent or Sibling on Invasive and In Situ Skin Cancer Risk in Sweden

Studies suggest that skin cancer aggregates within families; however, the risk of skin cancer associated with having an affected sibling or parent by subtype, tumor site, and age at diagnosis has not been established. The 2006 update of the Swedish Family-Cancer Database was used to calculate standardized incidence ratios (SIRs), representing the ratio of cancer risk among individuals with affecte

Cross-Sectional and Serial Correlation in a Small-Sample Homogeneous Panel Data Unit Root Test

In this paper, response surface parameters are provided that can be used to obtain critical values for an augmentation of an existing homogeneous panel data unit root test. The augmentation is performed to account for serial correlation in the disturbances. As the existing panel data unit root test is robust against cross-sectional correlation, the augmented test is robust against both cross-secti

Tyrosine hydroxylase expression is unstable in a human immortalized mesencephalic cell line - Studies in vitro and after intracerebral grafting in vivo

We have studied the stability of the dopaminergic phenotype in a conditionally immortalized human mesencephalic cell line, NIESC2.10. Even though MESC2.10 cells exhibit features of dopaminergic neurons in vitro, none of the cells expressed tyrosine hydroxylase (TH) after transplantation into a rat model of Parkinson's disease. We examined whether this is caused by cell death or loss of transmitter

New pharmacologic targets for the treatment of the overactive bladder: an update.

Although currently available antimuscarinic agents are the standard of care for overactive bladder (OAB), they are limited by certain side effects, particularly dry mouth and constipation. Research aimed at discovering new therapies for OAB has resulted in the identification of some promising drugs. Investigations of pharmacologic targets in the central nervous system (CNS) have yielded encouragin

S100B protein levels in saliva: correlation with gestational age in normal term and preterm newborns

Objectives: S100B is an acidic calcium-binding protein of the EF-hand family present in the central nervous system, where it is concentrated in glial cells. It has been suggested to act as a cytokine with neurotrophic effects at physiological concentrations. Design and methods: S100B concentration was assessed in saliva by western blot analysis and an immunoluminometric assay. A reference curve of

Rheumatoid Arthritis in an Icelandic Textbook from 1782

In 1782, Jon Petursson, a district physician in Northern Iceland, published a textbook on arthritis and its remedies intended for common use. Working within a very simple diagnostic system, essentially comprising osteoarthritis (arthritis h a ) and inflammatory arthritis (arthritis vaga), he describes arthritis vaga as a common, chronic, symmetric, destructive, inflammatory polyarthritis, sometime