•Apoptins are viral proteins that trigger cell death.•Apoptins show cancer-selective toxicity.•Potential delivery methods are being assayed for future apoptin clinical trials.Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal

Introduction Anal fistula is an abnormal tract with an external and internal opening that cause leakage, discomfort, and occasionally pain. Surgery is standard treatment, but recurrence and anal incontinence is common. The objective of the study was to analyze resource use, costs and sick leave for newly diagnosed patients with anal fistula in Sweden. Methods The study was based on register data f

The purpose of this paper is to describe and produce a more profound understanding of how communication professionals perceive that they realize strategic communication in organizations. Another aim is to deepen the understanding of what consequences the strategic work with communication has for the co-creation of meaning in which the organization is constituted. The paper is based on a qualitativ

Transposable elements (TEs) are DNA sequences that can insert elsewhere in the genome and modify genome structure and gene regulation. The role of TEs in evolution is contentious. One hypothesis posits that TE activity generates genomic incompatibilities that can cause reproductive isolation between incipient species. This predicts that TEs will accumulate during speciation events. Here, I tested

Multiparty government has often been associated with poor economic policy-making, with distortions like lower growth rates and high budget deficits. One proposed reason for such distortions is that coalition governments face more severe ‘common pool problems’ since parties use their control over specific ministries to advance their specific spending priorities rather than practice budgetary discip

Monitoring the aquatic environment and the life of free-floating organisms remains on the borderline of our technical capabilities. Therefore, our insights into aquatic habitats, such as, abundance and behavior of organisms are limited. In order to improve our understanding of aquatic life, we have developed a low-cost inelastic hyperspectral lidar with unlimited focal depth and enough sensitivity

A strategy for the detection of aflatoxin B1 using a capacitive biosensor has been studied. The use of proteins for the generation of sites with high specificity against aflatoxin B1 are produced via bioimprinting. This technique has become a tool for the detection of aflatoxin B1 using a capacitive biosensor. The results demonstrate the ability to generate specific interactions with aflatoxin B1

Odonata (dragonflies and damselflies) present an unparalleled insect model to integrate evolutionary genomics with ecology for the study of insect evolution. Key features of Odonata include their ancient phylogenetic position, extensive phenotypic and ecological diversity, several unique evolutionary innovations, ease of study in the wild and usefulness as bioindicators for freshwater ecosystems w

District heating satisfies about 60% of the heat demand in Swedish buildings. Today, more than two thirds of the heat supply to the district heating systems is based on biomass and waste, and biomass alone accounts for about half of the heat supply. The purpose of this paper is to present the Swedish experiences of introducing and expanding the use of biomass in the district heating systems and to

We have previously identified 20 different fusidic acid-resistant alleles of fusA, encoding mutant forms of the ribosomal translocase EF-G. One of these, P413L, is used here as the starting point in selections for internal revertants, identifying 20 different pseudo-wild-type forms of EF-G. We have also identified two alleles of fusA previously isolated as suppressors of 4.5 S RNA deficiency. All

Human bone marrow contains a population of non-hematopoietic stromal stem/progenitor cells (BMSCs), which play a central role for bone marrow stroma and the hematopoietic microenvironment. However, the precise characteristics and potential stem cell properties of defined BMSC populations have not yet been thoroughly investigated. Using standard adherent colony-forming unit fibroblast (CFU-F) assay

This study examines temporal trends in deaths due to fire-related accidents in Sweden from 1952 to 2013 based on statistics in the Cause of Death register held by the Swedish National Board of Health and Welfare. Fatalities coded with underlying cause of death associated with fire-related accidents are included and absolute numbers and age-adjusted mortality rates are calculated and statistically

Objective - To examine select adipokines, including fatty acid-binding protein 4, retinol-binding protein 4, and high-molecular-weight (HMW) adiponectin in relation to cardiovascular disease (CVD) mortality among patients with type 2 diabetes mellitus. Approach and Results - Plasma levels of fatty acid-binding protein 4, retinol-binding protein 4, and HMW adiponectin were measured in 950 men with

Retinal ischemia arises from circulatory failure. As the retinal blood vessels are key organs in circulatory failure, our aim was to study the retinal vasculature separately from the neuroretina to elucidate the role of hypoxia-inducible factor (HIF) 1α and 1β and vascular endothelial growth factor (VEGF) in retinal ischemia. Retinal ischemia was induced in porcine eyes by applying an intraocular

The genus Ipomoea (Convolvulaceae) is briefly presented. Well known representatives include sweet potato and morning glory.

Streptococcal pharyngitis is among the most common bacterial infections, but the molecular mechanisms involved remain poorly understood. Here we investigate the interactions among three major players in streptococcal pharyngitis: streptococci, plasma, and saliva. We find that saliva activates the plasma coagulation system through both the extrinsic and the intrinsic pathways, entrapping the bacter