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Molecular Pharmacology and Structure Function Modelling of the Leukotriene B4 Receptor BLT1

Leukotrienes are membrane derived bioactive lipids that play an important role in immune responses by initiating and maintaining the inflammatory responses. Leukotriene B4 (LTB4) released at the site of an inflammatory response attracts, activates and prolongs the life of leukocytes and lymphocytes. LTB4 can bind to two recently cloned cell surface G-protein coupled receptors named BLT1 and BLT2.

Hyperglycaemia and diabetic eye complications - a clinical and epidemiological study

Aim: To study the relationship between hyperglycaemia and the onset/progression of retinopathy, blindness/moderate visual impairment or death, as well as the impact of improved glycaemic control on retinopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). Methods: Between January 1990 and October 1995 a total of 3,220 diabetic patients were enrolled in a programme for control

The great escape: how exoplanets and smaller bodies desert dying stars

Mounting discoveries of extrasolar planets orbiting post-main-sequence stars motivate studies to understand the fate of these planets. In the traditional 'adiabatic' approximation, a secondary's eccentricity remains constant during stellar mass-loss. Here, we remove this approximation, investigate the full two-body point-mass problem with isotropic mass-loss, and illustrate the resulting dynamical

The role of young-of-the-year fish in lake ecosystems

Popular Abstract in Swedish Min avhandling handlar om vilken roll fiskyngel har i samspelet mellan olika organismer i våra sjöar, såsom i samspelet mellan rovfiskar, djurplanktonätande fiskar, djurplankton och alger. Fisklarver och fiskyngel förekommer i stora mängder i våra sjöar under sommaren. Varje vår/sommar kläcks nya kullar av bl.a. abborre och mörtlarver, vilka äter (prederar på) små djurFood chain theory is based on consumption; that is, presupposing that the only important interaction between organisms is that they actually meet in an unstructured environment and that one of them is consumed. Recently, studies, including biomanipulation projects, have indicated that trophic interactions are more complex than predicted by food chain theory. In this thesis I examine the role of yo

A CMOS implementation of a video-rate successive approximation A/D converter

Previous approaches to video-rate CMOS A/D (analog-to-digital) converters are based on fully-parallel, subrange, or pipeline architectures. The authors describe a 5-MHz 8-bit experimental design of a successive-approximation A/D converter using 3-μm CMOS technology. Since neither capacitors nor a resistor string are needed in the current-switching technique, a conventional digital technology can b