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Two series of C3-benzamido and O2-anion-substituted galactopyranosides were synthesized and studied as binders to arginine-rich proteins galectin-1, -3, -7, -8N (N-terminal domain), and -9N (N-terminal domain). The first series had a 4-methylbenzamide at C3 and the anionic O2-substituent was varied. The second series varied the 4-substituent of the C3-benzamide, whereas the anionic O2 substituent

Medicine, seen as an epistemological system, has broken down the knowledge of humans and their diseases into a growing number of smaller components. This has proven to be an effective and necessary way of creating and using knowledge. It is, of course, ne

Popular Abstract in English The human plasma proteome containing disease-correlated protein biomarkers reflects the pathological and physiological changes relating to diseases. These biomarkers are of interest to aid in diagnosis, prognosis and monitoring of diseases such as cancer. Because of the interests in the disease-correlated biomarkers, plasma, although is a complex biological sample, spanThe blood/plasma protein biomarker profile represents the pathological and physiological changes relating to human diseases. However, the plasma proteome reflects a high degree of complexity that results in a challenge for most analytical methods in clinical diagnostics. The focus in this thesis is the development and application of several integrated platforms to detect already established protei

Objective. To make an inventory of quality and content of currently available and published sets of health care quality indicators (HCQIs) for RA and OA.Methods. A systematic review was performed for documents on the development and/or a description of HCQIs for the management of patients with RA and/or OA, using the PubMed, EMBASE, Web of Science, Cochrane and CINAHL databases up to 1 December 20

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Nuclear quadrupole resonance (NQR) is a spectroscopic technique that can be used to detect many high explosives and narcotics. Unfortunately, the measured signals are weak, thereby inhibiting the widespread use of the technique. Current state-of-the-art detectors, which exploit realistic NQR data models, assume that the complex amplitudes of the NQR signal components are known, to within a multipl

Lantmäteriverket har uttryckt en vision om koordinatbestämda fastighetsgränser, med avsikt att skapa en i gränshänseende korrekt digital registerkarta. Ett förverkligande av visionen skulle kräva en förändring av gällande rätt, eftersom dagens gränssystem bygger på principen att gränsmärken på marken gäller framför andra uppgifter om gränsers sträckning. Hur en eventuell övergång till koordinatbes