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The nervous system is engaged by infection, indirectly through inflammatory cascades or directly, by bacterial attack on nerve cells. Here we identify a neuro-epithelial activation loop that participates in the control of mucosal inflammation and pain in acute cystitis. We show that infection activates Neurokinin-1 receptor (NK1R) and Substance P (SP) expression in nerve cells and bladder epitheli
There is growing evidence that a significant share of global food is thrown away, with concomitant detrimental repercussions for sustainability. Reducing food waste is a key sustainability challenge for the food service industry. Despite the significance of this issue to the global foodservice industry, the link between innovation practices and food waste management has received limited attention
This paper examines the linkages between cash-crop income and other dimensions of poverty to interrogate assumptions regarding the relationship between agricultural income and poverty alleviation. The analysis treats poverty as a multi-dimensional and socially disaggregated phenomenon. The paper employs a mixed methods approach to case studies of Ghana and Ethiopia to explore two critical issues.
The Faroe Islands hold a key position in the North Atlantic region for tephra studies due to their relative proximity to Iceland. Several tephras have been described over the last 50 years in peat and lake sediment sequences, including the type sites for the Saksunarvatn and Mjáuvøtn tephras. Here we present a comprehensive overview of Holocene tephras found on the Faroe Island. In total 23 tephra
To assess the potential impact of ICT on environmental sustainability in the European Union within a time horizon until 2020, we developed a System Dynamics model. In our contribution we make a critical, retrospective evaluation of the model with regard to the requirements and expectations of the project commissioners and of experts involved in the modeling and simulation process. The issues addre
While the number of stars in the Galactic bulge with detailed chemical abundance measurements is increasing rapidly, the inner Galactic bulge (|b| < 2°) remains poorly studied, due to heavy interstellar absorption and photometric crowding. We have carried out a high-resolution IR spectroscopic study of 72 M giants in the inner bulge using the CRIRES (ESO/VLT) facility. Our spectra cover the wavele
In this study, a three-dimensional, non-isothermal, two-phase flow mathematical model is developed and applied to investigate the effect of the GDL deformation on transport phenomena and performance of proton exchange membrane (PEM) fuel cells with interdigitated flow fields. The thickness and porosity of the GDL is decreased after compression, and the corresponding transport parameters (permeabil
Thrombin-derived C-terminal peptides (TCPs) of about 2 kDa are present in wounds, where they exert anti-endotoxic functions. Employing a combination of nuclear magnetic resonance spectroscopy (NMR), biophysical, mass spectrometry and cellular studies combined with in silico multiscale modelling, we here determine the bound conformation of HVF18 (HVFRLKKWIQKVIDQFGE), a TCP generated by neutrophil e
Air pollution by lead, even in small concentrations, can cause serious health effects. In the atmosphere this element can generally be found in particulate matter (PM), and in general in small concentrations. This work proposes the development of an analytical method for lead determination in inhaled PM based on ultrasound-assisted extraction with subsequent supramolecular solvent based dispersive
Bisphenol A (BPA) exposure has been linked to neurodevelopmental disorders and to effects on epigenetic regulation, such as DNA methylation, at genes involved in brain function. High doses of BPA have been shown to change expression and regulation of one such gene, Grin2b, in mice. Yet, if such changes occur at relevant doses in animals and humans has not been addressed. We investigated if low-dos
Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1
Cities are increasingly facing major transportation challenges, and new sustainable solutions are needed. New ICT-enabled services can be part of solving the problems, including both improving and finding new transportation services and providing digital access to different services. It is important to identify which services have the best potential for environmental benefits (e.g., travel reducti
Heusler compounds are a ripe platform for discovery and manipulation of emergent properties in topological and magnetic heterostructures. In these applications, the surfaces and interfaces are critical to performance; however, little is known about the atomic-scale structure of Heusler surfaces and interfaces or why they reconstruct. Using a combination of molecular beam epitaxy, core-level and an
Organometal halide perovskites in the form of nanocrystals (NCs) have attracted enormous attention due to their unique optoelectronic and photoluminescence (PL) properties. Here, we examine the phase composition and the temperature dependence of emission line width broadening in formamidinium lead bromide (FAPbBr3) perovskite nanocrystals (NCs) for light-emitting applications and identify differen
This thesis deals with epitaxial growth and optical properties of semiconductor nanowires with implications and insights about materials for solar cells. The chapters leading up to the papers give a broader background and an introduction to the field and include nanowires and their synthesis, semiconductor properties, solar cell operational principles, light interaction with a nanowire array, and
In this paper, we analyze experimental data from state-of-the-art vertical InAs/InGaAsSb/GaSb nanowire Tunnel Field-Effect Transistors to study influence of the source doping on their performance. Overall, the doping level impacts both off-state and on-state performance of these devices. Separation of the doping from the heterostructure improved the subthreshod swing of the devices. Best devices r
"Föreliggande bok grundar sig på en artikelserie i tidningen Elteknik under åren 1974-1976. Artikelserien byggde ursprungligen på en kurs "Datorer i reglersystem" som förelästes första gången vid Tekniska Högskolan i Lund 1973.
Steady-state laminar natural convection of Cu and TiO2 nanofluids inside different enclosures is numerically investigated. Natural convection is concerned due to a temperature difference between the hot and cold surfaces. The Boussinesq approximation is used to form the governing equations and the commercial software package ANSYS FLUENT version 14.0 is used to numerically solve the governing equa
