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EF-hand proteins are central in many cellular processes being the main group of Ca2+-sensing and buffering proteins in the cell. In the work presented in this thesis we study ligand interactions of three EF-hand proteins; calmodulin, calbindin D28k and secretagogin. We have developed a screening method using proteins arrays and validation of targets with surface plasmon resonance. With have applie
We consider a probabilistic model for workload input into a telecommunication system. It captures the dynamics of packet generation in data traffic as well as accounting for long-range dependence and self-similarity exhibited by real traces. The workload has stationary increments as observed in high-speed data networks for certain periods. Such periods with peak demand can be studied with this mod
The present paper investigates the contemporary intersections of nation and church in two Balkan states, Romania and Serbia, as they are specifically articulated with the help of political myth. Myths are understood here as narratives about the past of a given national community that bring cohesion to the group. The political aspect of myth lies in its use by political actors and in its potential
Different aspects of the integration of conventional control system and knowledge-based systems are discussed. Special requirements such as multiple forms of knowledge representation, support for model-based reasoning, and real-time operation are discussed. Three different forms of integration are described: interfaced systems, embedded systems, and totally integrated systems.
The transport sector accounts for approximately 20% of EU-27 greenhouse gas (GHG) emissions, and 27% of U.S. GHG emissions. With the Kyoto Protocol, Sweden and several other nations have agreed to reduce these emissions. Often, solutions that involve consolidating freight and moving it to more carbon-efficient transport technologies are advocated as the most advantageous. For such initiatives the
A fedbatch process shows exponential growth under ideal conditions. To obtain good substrate concentration control it is necessary that the regulator can track an exponentially growing feed demand, and standard PI-control has to be supplemented with an estimated basic dosage to get reasonable control. However, an exponentially growing concentration error is impossible to avoid. An I-term could be
