The voltage-gated Ca2+ channel is the Ca2+ sensor of fast neurotransmitter release
Previously it demonstrated that in the absence of Ca2+ entry, evoked secretion occurs neither by membrane depolarization, induction of [Ca2+]i rise, nor by both combined (Ashery, U., Weiss, C., Sela, D., Spira, M. E., and Atlas, D. (1993). Receptors Channels 1:217-220.). These studies designate Ca2+ entry as opposed to [Ca2+]i rise, essential for exocytosis. It led us to propose that the channel a
