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Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a
The influence of military members’ malevolent personality traits on their ethical attitudes and behaviors has been the subject of research for decades. We investigated the relationship between malevolent individual difference factors (Machiavellianism, narcissism, psychopathy, the dominance facet of social dominance orientation, and right-wing authoritarianism) and aspects of military ethics befor
•Robberies as well as mental distress have increased among adolescents in Sweden.•This study on school students in southern Sweden was population-based with a high response rate.•Half of the robbed adolescents abstained from police reporting.•Non-reporters had poorer mental health than victims who reported the robbery.•Non-reporters were also an overall more disadvantaged group.
Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how
Icke-förskriven användning av opioidläkemedel, såsom tramadol, är ett stort globalt hälsoproblem. I Sverige har användningen av tramadol bland unga uppmärksammats stort och lyfts fram som ett nytt droganvändningsmönster. Det övergripande syftet med denna licentiatuppsats är att utforska droganvändningsförlopp och processen att försöka sluta med droger bland unga med erfarenhet av problematiskt traNon-medical use of prescription opioids, such as tramadol, is a major global health concern. In Sweden, tramadol use among young people is widely recognized and highlighted as a novel drug use pattern. The overall aim of this licentiate thesis is to explore drug use trajectories and the process of attempting to quit drugs among young people with experiences of problematic tramadol use. 24 qualitat
A palliative cancer diagnosis in a parent has a major impact on many aspects of their children’s lives. Studies show that professionals do not seem to offer relatives, in general, much attention in the palliative fieldAim: To explore how doctors and social workers handle children of cancer patients in order to understand the possibilities and difficulties in supporting children in specialized pall
MIMO is an undisputed breakthrough in advanced wireless technology, as it offers potentially linear increase in information-theoretic capacity with the number of antennas. However, the implementation of MIMO in compact terminals is a relatively uncharted topic, due to challenging problems with high antenna correlation and mismatch loss, both of which greatly reduces the expected MIMO gains. In thi
BACKGROUND: A key component of achieving universal health coverage is ensuring that all populations have access to quality health care. Examining where gains have occurred or progress has faltered across and within countries is crucial to guiding decisions and strategies for future improvement. We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) to assess person
This study uses a novel approach to identifying local contextual conditions conducive, alone or in combination to far-right political violence. The studied case is asylum housing attacks occurring in Sweden 2015-16. Using a fuzzy-set qualitative comparative analysis of eighty-six Swedish municipalities, forty-two of which have experienced arson attacks against refugee housing facilities, we operat
We combine socioeconomic data from a large-scale household survey with historical climate data to map the climate sensitivity of availability and access dimensions of food security in Mali, and infer the ways in which at-risk communities may have been impacted by persistent climatic shift. Thirty years after 1982–1984, the period of most intense drought during the protracted late 20th century dryi
De som både jobbar och hjälper äldre anhöriga riskerar försämrad hälsa såväl som ekonomi. Villkoren för dem som utför obetalt omsorgsarbete måste förbättras, skriver Maria Stanfors i en ny SNS-rapport.
Many types of microneedle (MN) arrays have been tested for delivery of vaccines to the skin. However, the effect of MN geometry/array design on antibody production is still unclear. Reports suggest that systemic immune responses may be affected by how MN arrays “mechanically” deliver vaccines, which can induce cell damage and act as an adjuvant. This includes parameters such as MN length/insertion
Samples of Fucus serratus and Fucusvesiculosus taken in Swedish coastal waters have beenanalysed for Gd by ICP-MS. The results for one site withfrequent sampling show significantly increasing levelsduring the last 30 years, most likely a result of theincreasing use of Gd-containing contrast agents for MR-imaging at hospitals and other health care institutions.Samples taken at the west-, south- and
This update of the Ok (OK) blood group system (Smart EA, Storry JR. The OK blood group system: a review. Immunohematology 2010;26:124-6) focuses on new information on the role of basigin (BSG), the carrier molecule of the Ok blood group antigens. No further antigens have been identified since the original review. However, the role of BSG in malaria continues to be explored. Immunohematology 2021
Owing to climate change, population growth and tenurial changes, the past decade has witnessed high interest among migrant and settler pastoralist groups in thevegetal-rich customary lands of the Agogo Traditional Area. This has resulted in lease grants of large land areas to pastoralists by traditional authorities and usufructfamilies, for reasons of ensuring optimum use and gaining the highest r
