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Urinary flow measurement in hypospadias correlated to surgical procedure and risk of development of urethra-cutaneous fistula

Aim: To explore the correlation between fistula development and urinary flow measurements after hypospadias repair with emphasis on patients with urethrocutaneous fistula complications and to identify risk factors for fistula development. Methods: Urinary flow was examined in boys operated on for hypospadias. Outcome of maximum urinary flow (ml/s) (Qmax), voided volume for age (ml) (Volume), and p

Interferon-Gamma Receptor Signaling Plays an Important Role in Restraining Murine Ovarian Tumor Progression

Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelia

Granzyme B-mediated damage of CD8+ T cells impairs graft-versus-tumor effect

Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and other malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the treatment. Using multiple tumor models and diverse donor-host combinations, we have studied the role of granzyme B (GzmB) in GVT effect. We first conf

A TLR5 agonist enhances CD8(+) T cell-mediated graft-versus-tumor effect without exacerbating graft-versus-host disease

Allogeneic hematopoietic cell transplantation is an established treatment for hematologic and nonhematologic malignancies. Donor-derived immune cells can identify and attack host tumor cells, producing a graft-versus-tumor (GVT) effect that is crucial to the effectiveness of the transplantation therapy. CBLB502 is a novel agonist for TLR5 derived from Salmonella flagellin. On the basis of TLR5-med

Rapid analysis methods for paralytic shellfish poisoning toxins (PSTs) monitoring in raw waters

The presence of paralytic shellfish poisoning toxins (PSTs) in drinking water resources has urged the development of simple and fast screening tools for drinking water surveillance. This article aims to validatea quick test kit for freshwater PSTs detection. Preliminary estimates of the limit of detection (LODs)were done for 5 PSPs variants, namely C1 toxin (a “C” toxin); GTX5(a Gonyautoxin); and

Hetero-nuclear STEAM: Localisation of 13C MR-spectroscopy using {1H-13C} polarisation transfer and 1D phase encoding

Abstrakt. Gradientval av överföringar gör det möjligt att förenkla polarisationsöverföringssekvenser genom att utelämna kemiska skift-återfokuseringspulser. Funktionerna hos en förenklad STEM-sekvens med tre pulser för {1H-13C} polarisationsöverföring har studerats vid 2 Tesla på ett helkropps MR-system med avseende på användning av MR-spektroskopi in vivo. Den observerade signalen ökas genom nett

Sex pheromone components of Mamestra suasa : chemical analysis, electrophysiological activity, wind tunnel activity and field tests in two European countries

(Z)‐11‐hexadecenyl acetate (Z‐11–16:Ac), (Z)‐11‐hexadecenal (Z‐11–16:Ald), (Z)‐11‐hexadecenol (Z‐11–16:OH) and hexadecanyl acetate (16:Ac) were found in pheromone gland extracts of female Mamestra suasa (Den. et Schiff.) in the relative amounts 100/2/10/5. All four compounds were also present in collections of airborne volatiles from calling females in a 100/7/5/5 ratio. No traces of 14 carbon ald

Individual variation in the pheromone of the turnip moth, Agrotis segetum

Female turnip moths (Agrotis segetum) from a laboratory culture inbred for more than 30 generations, and the offspring (first and third generation) from field-collected insects were analyzed individually for acetates and alcohols in the pheromone gland. Quantitative analysis of individual components was performed at the subnanogram level by gas chromatographymass spectrometry (selected ion monitor

Sex pheromone components of the turnip moth, Agrotis segetum - Chemical identification, electrophysiological evaluation and behavioral activity

Analysis of female abdominal tips of Agrotis segetum by means of GC-MS showed the presence of 13 aliphatic acetates and alcohols. (Z)-7-Dodecenyl acetate was found to be the main component in the extracts at amounts of about 1 ng/female. (Z)-9-Tetradecenyl acetate and (Z)-7-dodecenol were present to the extent of 49 and 19%, respectively, of the main component. Minor components could be identified