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To what extent can evaluation frameworks help NGOs to address health inequalities caused by social exclusion?

Tackling health inequalities is a top priority for public health services in England. Third sector organisations, or non-governmental organisations (NGOs), are seen as having a key role in providing these services, particularly to the socially excluded, often dubbed ‘hard to reach’, for whom services must be provided if health inequalities are to be reduced. The plethora of evaluation frameworks a

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia.

The adaptor protein Grb10 plays important roles in mitogenic signaling. However, its roles in acute myeloid leukemia (AML) are predominantly unknown. Here we describe the role of Grb10 in FLT3-ITD-mediated AML. We observed that Grb10 physically associates with FLT3 in response to FLT3-ligand (FL) stimulation through FLT3 phospho-tyrosine 572 and 793 residues and constitutively associates with onco

Antiproliferative Activity of Melanoidins Isolated from Heated Potato Fiber (Potex) in Glioma Cell Culture Model

Potex constitutes a potato fiber preparation widely used as an ingredient to meat and bakery products which thermal treatment results in creation of new compounds. Melanoidins are high molecular weight brown end products of Maillard reaction, and few data presenting tumor cell growth inhibiting activity of melanoidins have been reported. Thus, in present study we utilized water extract of Potex ro

Accessible Transportation, Geographic Elevation, and Masticatory Ability Among Elderly Residents of a Rural Area.

Given that public transportation networks are often worse in rural areas than in urban areas, rural residents who do not drive can find it difficult to access health-promoting goods, services, and resources related to masticatory ability. Moreover, geographical location, assessed by elevation, could modify this association. The aim of this study was to test whether the association between access t

A cross-contamination-free SELEX platform for a multi-target selection strategy

Multi-target aptamer selection, known as multiplex systematic evolution of ligands by exponential enrichment (SELEX), is rapidly drawing interest because of its potential to enable high-speed, high-throughput aptamer selection. The parallelization of chemical processes by integrating microfluidic unit operations is a key strategy for developing a multiplex SELEX process. One of the potential probl

First neuropathological description of a patient with Parkinson's disease and LRRK2 p.N1437H mutation.

The c.4309A>C mutation in the LRRK2 gene (LRRK2 p.N1437H) has recently been reported as the seventh pathogenic LRRK2 mutation causing monogenic Parkinson's disease (PD). So far, only two families worldwide have been identified with this mutation. By screening DNA from seven brains of PD patients, we found one individual with seemingly sporadic PD and LRRK2 p.N1437H mutation. Clinically, the patien

The effect of extremely preterm birth on attachment organization in late adolescence

Background Prior studies have examined the impact of preterm birth on the quality of the attachment relationship to the mother in infancy, but few have examined extremely preterm born infants and almost no data have been reported on prematurity and its impact on the attachment organization attained after childhood. Methods Thirty-nine adolescents born extremely preterm and 39 full-term born contro

Line-of-Sight Obstruction Analysis for Vehicle-to-Vehicle Network Simulations in a Two Lane Highway Scenario

In vehicular ad-hoc networks (VANETs) the impact of vehicles as obstacles has largely been neglected in the past. Recent studies have reported that the vehicles that obstruct the line-of-sight (LOS) path may introduce 10-20 dB additional loss, and as a result reduce the communication range. Most of the traffic mobility models (TMMs) today do not treat other vehicles as obstacles and thus can not m

Choice of primary care in Sweden: a discourse analysis of citizen statements

Through a discourse analysis of the end-users’ statements on their choice of primary care, there is a focus on how they use certain discourses in society with regard to which discourses governs their choices of primary care. For this purpose, a group interview was administered in a location in the south of Sweden. It was strategically designed to on the whole include individuals with following cha

Optimal results for the nonhomogeneous initial-boundary value problem for the two-dimensional Navier-Stokes equations

In this work we study the fully nonhomogeneous initial boundary value problem for the two-dimensional time-dependent Navier–Stokes equations in a general open space domain in R2 with low regularity assumptions on the initial and the boundary value data. We show that the perturbed Navier–Stokes operator is a diffeomorphism from a suitable function space onto its own dual and as a corollary we get t

Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury

Galectin-3 (Gal-3), an endogenous lectin, exhibits ro- and anti-inflammatory effects in various disease conditions. In order to explore the role of Gal-3 in KT-cell-dependent pathology, we induced hepatitis in C57BL/6WT and al-3-deficient mice by using specific ligand for KT cells: alpha-galactosylceramide, glycolipid Ag presented by CD1d. The injection of alpha-galactosylceramide significantly en

Dependence on Vitamin K-dependent Protein S for Eukaryotic Cell Secretion of the beta-Chain of C4b-binding Protein

The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 alpha-chains and 1 beta-chain (C4BP beta(+)), the chains being linked by disulfide bridges. PS binds to the beta-chain with high affinity. In plasma, PS is in molar excess over C4BP

Changes in behaviour and cytokine expression upon a peripheral immune challenge

Depression is frequently associated with inflammation. Animal studies have shown that peripheral inflammation induces depressive-like behaviour, but the underlying mechanisms remain unclear. A distinction between sickness- and depressive-like behaviour has been proposed. We hypothesize that the behavioural distinction is due to changes in the central production of immune mediators. As a model of p

The role of discourses in governing forests to combat climate change

Reducing emissions from forest degradation and deforestation, conserving and enhancing forest carbon stocks, and sustainably managing forests (REDD+) has emerged as one of the most anticipated climate change mitigation tools. This paper aims to understand and identify the underlying discourses that have dominated the emergence of REDD+, by identifying the key story lines in the policy and academic

Longitudinal changes in weight in relation to smoking cessation in participants of the EPIC-PANACEA study

Purpose. We assessed the association between smoking cessation and prospective weight change in the European population of the European Prospective Investigation into Cancer and Nutrition-Physical Activity, Nutrition, Alcohol, Cessation of smoking. Eating out of home And obesity (EPIC-PANACEA) project. Methods. The study involved more than 300,000 healthy volunteers, recruited between 1992 and 200

Too heavy, too late: investigating perinatal health outcomes in immigrants residing in Spain. A cross-sectional study (2009-2011).

Studies have shown that immigrants residing in Spain have lower risks of delivering low birthweight (LBW) and preterm babies despite their socioeconomic disadvantages (the healthy migrant paradox). However, less is known about other important perinatal outcomes derived from birth weight and gestational age such as macrosomia and post-term birth. This paper aims to compare the main indicators relat

Identification of prostate specific antigen (PSA) isoforms in complex biological samples utilizing complementary platforms

Measurements of the prostate-specific antigen (PSA) levels in blood are widely used as diagnostic, predictive and prognostic marker of prostate disease. The selective detection of molecular forms of PSA can contribute clinically to meaningful enhancements of the conventional PSA-test. As it is plausible that an in-depth search for structural variants of PSA gene products may increase our ability t