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Aortic smooth muscle cells produce chondroitin/dermatan sulfate (CS/DS) proteoglycans that regulate extracellular matrix organization and cell behavior in normal and pathological conditions. A unique feature of CS/DS proteoglycans is the presence of iduronic acid (IdoA), catalyzed by two DS epimerases. Functional ablation of DS-epi1, the main epimerase in these cells, resulted in a major reduction

We present a quantized model of a harmonically confined dot atom with inherent damping in the presence of a transverse magnetic field. The model leads to a non-Hermitian Hamiltonian in coordinate space. We have analytically studied the effects of damping on Rabi type oscillations of the system. The model explains the decoherence of Rabi oscillations in a Josephson Junction.

In this work, we discuss the possibility of a new approach to measuring oxygen isotope ratios in fossil meteorite samples, specifically one based on nuclear reaction analysis (NRA). Variations of oxygen ratios within meteoritic chromite grains can help to determine the type of meteorite to which the grains originally belonged. In this work, we have evaluated the possibility to use the reaction O-1

Popular Abstract in Swedish Stora resurser används i processindustrin, och i många andra industribranscher, på att rapportera incidenter för att utnyttja erfarenheterna från dessa för att förebygga framtida incidenter – alltifrån mindre störningar till olyckor med stora konsekvenser. Det finns emellertid en hel del som tyder på att man ofta utnyttjar bara en del av hela den potential för lärande sLearning from incidents (from minor disturbances to major accidents) is considered one of the most important ways in the process industry to learn from experiences for improving safety performance. Most companies have a formal incident learning system and considerable resources are used for reporting incidents and for utilising these experiences to prevent future incidents. However, there are many

Background: It is well established that drinking alcohol raises the risk of liver cancer (hepatocellular carcinoma). However, it has not been sufficiently established as to whether or not drinking cessation subsequently reduces the risk of liver cancer and if it does reduce the risk how long it takes for this heightened risk to fall to that of never drinkers. This question is important for effecti

A monograph of the genus Placomaronea is presented; all species described earlier are revised, a total of six species is recognized, and an identification key is presented. In addition to the three previously known species, P. candelarioides, P. lambii and P. mendozae, three new species are described: Placomaronea kaernefeltii is a large rosette-like species known from one locality in northernmost

Objectives: Several studies have suggested that genotoxic risks might still be present in the contemporary rubber manufacturing industry. Previously, we observed elevated levels of urinary mutagenicity and bladder DNA adducts in rubber workers. Presently, we investigated whether DNA adducts in peripheral blood mononuclear cells (PBMC) and/or urothelial cells may be caused by polycyclic aromatic hy

To better understand and characterize chromosomal structural variation during breast cancer progression, we enumerated chromosomal rearrangements for 11 patients by performing low-coverage whole-genome sequencing of 11 primary breast tumors and their 13 matched distant metastases. The tumor genomes harbored a median of 85 (range 18-404) rearrangements per tumor, with a median of 82 (26-310) in pri

Using an eight-band k . p model Hamiltonian with the Burt-Foreman envelope function theory, we have investigated the optical absorption of both linearly and circularly polarized light, as well as related phenomena in InAs/GaSb broken-gap quantum wells grown along the [0 0 1] direction, with emphasis on the effects of electron-hole hybridization and the various symmetry-breaking mechanisms such as

Glioblastoma multiforme (GBM) is the most common primary brain tumor in the central nervous system and the prognosis is very poor despite conventional therapies including surgery, chemo- and radiotherapy. Peripheral vaccination with irradiated tumor cells represent a novel therapy that targets both dividing and non-dividing tumor cells and minimizes the risk of therapy resistance by presenting mul

We present a catalog of high-energy gamma-ray sources detected by the Large Area Telescope (LAT), the primary science instrument on the Fermi Gamma-ray Space Telescope (Fermi), during the first 11 months of the science phase of the mission, which began on 2008 August 4. The First Fermi-LAT catalog (1FGL) contains 1451 sources detected and characterized in the 100 MeV to 100 GeV range. Source detec

The development of dental materials with improved properties and increased longevity can save costs and minimize discomfort for patients. Due to their good biocompatibility, glass ionomer cements are an interesting restorative option. However, these cements have limited mechanical strength to survive in the challenging oral environment. Therefore, a better understanding of the structure and hydrat

The aim of the work described in this thesis was to evaluate the value of ultrasound examinations of the amniotic fluid, umbilical cord and blood flow velocity waveform of the fetal and placental vessels as predictors of the perinatal outcome. In the first study, the amniotic fluid index (AFI) measured on admission to the labour ward was evaluated in low-risk pregnancies. An increased risk of ope

Diabetes Mellitus is a chronic disease, where the blood glucose concentration of the patient is elevated. This is either because of missing insulin production due to failure of the β-cells in the pancreas (Type 1) or because of reduced sensitivity of the cells in the body to insulin (Type 2). The therapy for Type 1 diabetic patients usually consists of insulin injections to substitute for the miss

The COST 2100 channel model has introduced the concept of common clusters to model multi-link MIMO characteristics. In this paper, a ray launching tool is used to analyze multi-ink propagation properties in an outdoor scenario at 300 MHz. It is shown that in a multi-link propagation scenario there are shared scatterers among the different links, which reflects the physical existence of common clus

Sepsis and septic shock remain important medical problems with high mortality rates. Today's treatment is based mainly on using antibiotics to target the bacteria, without addressing the systemic inflammatory response, which is a major contributor to mortality in sepsis. Therefore, novel treatment options are urgently needed to counteract these complex sepsis pathologies. Heparin cofactor II (HCII